SERUM LEVELS OF OXIDATIVE STRESS MARKERS IN SUBCLINICAL AND OVERT HYPOTHYROIDISM VERSUS CONTROL GROUP IN POPULATION OF KUTAHYA CITY, TURKEY
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gomal Medical Coll
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Overproduction of oxygen-related free radicals and inadequate antioxidant defense are critical in hypothyroidism, as they might lead to future life-threatening diseases. The objectives of this study were to compare serum levels of oxidative stress markers; total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase-1 (PON-1), and arylesterase (ARYL) in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) versus healthy controls in population of Kutahya city, Turkey. Materials & Methods: This cross-sectional study was conducted at Department of Biochemistry, Faculty of Medicine, Kutahya University of Health Sciences, Kutahya, Turkey, from July to December, 2016. Three study groups of 45 each were formed as healthy controls, patients with SH and OH. Serum levels of TOS, TAS, OSI, PON-1, and ARYL were five research variables with ratio scale, but skewed, so described by median and IQR with 95% Cl. Kruskal-Wallis and multiple comparison tests were used for hypotheses testing. Results: Serum levels of TOS and OSI were higher in SH group (p-values 0.032; <.0001; respectively) and OH group (p-values <.0001; <.0001, respectively) than healthy controls, while serum levels of TAS, PON-1 and ARYL were lower in SH group (p-values <.0001; <.0001; <.0001, respectively) and OH group (p-values <.0001; <.0001; <.0001, respectively) than control group. Conclusion: Our study showed that serum levels of TOS and OSI were higher in subclinical and overt hypothyroidism than in healthy controls; while serum levels of TAS, PON-1, and ARYL were lower in subclinical and overt hypothyroidism than in healthy controls.
Açıklama
Anahtar Kelimeler
Hypothyroidism, Thyroid Stimulating Hormone, Oxidants, Antioxidants, Oxidative Stress, Paraoxonase-1, Total Oxidant Status, Total Antioxidant Status, Oxidative Stress Index, Arylesterase
Kaynak
Gomal Journal Of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
19
Sayı
4
