SERUM LEVELS OF OXIDATIVE STRESS MARKERS IN SUBCLINICAL AND OVERT HYPOTHYROIDISM VERSUS CONTROL GROUP IN POPULATION OF KUTAHYA CITY, TURKEY

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dc.contributor.authorYontem, Mustafa
dc.contributor.authorArslan, Serap
dc.contributor.authorErdogdu, Behic Selman
dc.contributor.authorKocak, Fatma Emel
dc.date.accessioned2024-02-23T14:40:49Z
dc.date.available2024-02-23T14:40:49Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: Overproduction of oxygen-related free radicals and inadequate antioxidant defense are critical in hypothyroidism, as they might lead to future life-threatening diseases. The objectives of this study were to compare serum levels of oxidative stress markers; total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase-1 (PON-1), and arylesterase (ARYL) in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) versus healthy controls in population of Kutahya city, Turkey. Materials & Methods: This cross-sectional study was conducted at Department of Biochemistry, Faculty of Medicine, Kutahya University of Health Sciences, Kutahya, Turkey, from July to December, 2016. Three study groups of 45 each were formed as healthy controls, patients with SH and OH. Serum levels of TOS, TAS, OSI, PON-1, and ARYL were five research variables with ratio scale, but skewed, so described by median and IQR with 95% Cl. Kruskal-Wallis and multiple comparison tests were used for hypotheses testing. Results: Serum levels of TOS and OSI were higher in SH group (p-values 0.032; <.0001; respectively) and OH group (p-values <.0001; <.0001, respectively) than healthy controls, while serum levels of TAS, PON-1 and ARYL were lower in SH group (p-values <.0001; <.0001; <.0001, respectively) and OH group (p-values <.0001; <.0001; <.0001, respectively) than control group. Conclusion: Our study showed that serum levels of TOS and OSI were higher in subclinical and overt hypothyroidism than in healthy controls; while serum levels of TAS, PON-1, and ARYL were lower in subclinical and overt hypothyroidism than in healthy controls.en_US
dc.identifier.doi10.46903/gjms/19.04.935
dc.identifier.endpage140en_US
dc.identifier.issn1819-7973
dc.identifier.issn1997-2067
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85134818161en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.46903/gjms/19.04.935
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16599
dc.identifier.volume19en_US
dc.identifier.wosWOS:000740735900003en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGomal Medical Collen_US
dc.relation.ispartofGomal Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypothyroidismen_US
dc.subjectThyroid Stimulating Hormoneen_US
dc.subjectOxidantsen_US
dc.subjectAntioxidantsen_US
dc.subjectOxidative Stressen_US
dc.subjectParaoxonase-1en_US
dc.subjectTotal Oxidant Statusen_US
dc.subjectTotal Antioxidant Statusen_US
dc.subjectOxidative Stress Indexen_US
dc.subjectArylesteraseen_US
dc.titleSERUM LEVELS OF OXIDATIVE STRESS MARKERS IN SUBCLINICAL AND OVERT HYPOTHYROIDISM VERSUS CONTROL GROUP IN POPULATION OF KUTAHYA CITY, TURKEYen_US
dc.typeArticleen_US

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