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Öğe Anaphylaxis in The Newborn with a Diagnosis of Cutaneous Mastocytosis: Case Report and Literature Review(Galenos Yayincilik, 2017) Tarakci, Nuriye; Konak, Murat; Daye, Munise; Altunhan, Huseyin; Ors, RahmiMastocytosis is carachterized by excessive mast cell accumulation in the skin and/or internal organs. Mastocytosis is divided into two groups; systemic and cutaneous. Symptoms depend on excessive cytokine release and their local and systemic affects. Symptoms may be mild or cause life-threatening anaphylactic reactions. In the literature anaphylactic reactions reported in systemic disease of adult and childhood mastocytosis. We here present an anaphylaxis in the newborn with a diagnosis of cutaneous mastocytosis.Öğe Birth weight and gestational age in newborns exposed to maternal obsessive-compulsive disorder(Elsevier Ireland Ltd, 2015) Uguz, Faruk; Yuksel, Goksen; Karsidag, Cagatay; Guncu, Hatice; Konak, MuratWe examined the impact of maternal obsessive-compulsive disorder (OCD) on gestational age and birth weight of infants. The sample included 63 mothers (28 patient and 35 controls). OCD and other psychiatric diagnoses were determined with a structured clinical interview. Birth weight and gestational age were lower in the newborns exposed to maternal OCD compared to ones who were not exposed. The results suggest that maternal OCD may negatively affect fetal weight growth and gestational duration. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Öğe Congenital Nephrotic Syndrome: Case Report and Review of Literature(Cukurova Univ, Fac Medicine, 2012) Konak, Murat; Annagur, Ali; Altunhan, H.; Atas, Bulent; Ors, RahmiCongenital nephrotic syndrome (CNS) is a rare kidney disease which reveals itself after birth and characterized with severe proteinuria, hypoalbuminemia and edema. It is a genetic disorder that occurs with deterioration of glomerular filtration barrier especially as a result of mutation that develops in genes called nephrin and podocin. CNS could be as a result of perinatal infection as well as a part of a genetic syndrome. Immune suppressive treatment is ineffective in genetically originated CNS, however renal transplantation yields curative treatment. In many cases to prevent from life threatening edema, daily albumin infusion is needed. Additionally, high caloric diet, thyroxin and mineral supply are applied. Also prophylaxis of thrombolytic complications and opportunistic infection that could develop due to immune deficiency is needed. In this report we discussed a case with the review of literature by reporting a newborn which had CNS diagnosis as a result of persistent hypoalbuminemia and proteinuria without edema.Öğe Duktus Bağımlı Konjenital Kalp Hastalıklarında Oral Prostaglandin E1 Tedavisinin Değerlendirilmesi(2012) Altunhan, Hüseyin; Annagür, Ali; Ertuğrul, Sabahattin; Konak, Murat; Şap, Fatih; Karaaslan, Sevim; Örs, RahmiAmaç: İntravenöz prostaglandin E1 (PGE1) infüzyonu duktus bağımlı konjenital kalp hastalarında etkisi kanıtlanmış bir ilaçtır. Ancak intravenöz PGE1 oldukça pahallı, sürekli intravenöz infüzyon gerektiren ve her merkezce temini zor bir ilaçtır. Uzun süre kullanılması gerektiğinde bu sorunlar daha önemli hale gelmektedir. Bu çalışmada Oral PGE1in intravenöz PGE1 temin edilinceye kadar duktusun açık kalmasını sağlayıp sağlamadığını göstermek amaçlanmıştır. Yöntem: Yenidoğan yoğun bakım ünitesine duktus bağımlı konjenital kalp hastalığı tanısıyla yatırılıp intravenöz PGE1 temin edilinceye kadar oral PGE1 verilen 10 hasta retrospektif olarak incelendi. Hastaların oral PGE1 ve intravenöz PGE1 başlanmadan önce ve sonra arteryal kan gazında pO2 ve ciltten bakılan sO2 değerleri kaydedildi. Bulgular: Oral PGE1 tedavisine ortalama başlama yaşı 5.5 saat (0.525), verilme süresi 28 saat (1846) idi. Hastaların oral PGE1 başlandıktan 2 saat sonra alınan pO2 ve sO2 değerlerinin başlanmadan önceki değerlerine göre istatistiksel olarak anlamlı bir şekilde arttığı gözlendi. PO2 ve SO2 düzeyindeki düzelme intravenöz PGE1 başlanıncaya kadar devam etti. İntravenöz PGE1 başlandıktan 2 saat sonra bakılan PO2 ve SO2 değerlerinin intravenöz PGE1 başlanmadan önce bakılan değerlerine göre bir miktar daha artış gösterdiği gözlendi. Sonuç: Kısa süreli kullanımda intravenöz PGE1 oral PGE1den daha etkili olsa da oral PGE1de duktusun açık kalmasında yeterince etkilidir. Bu nedenle intravenöz PGE1 temin edilinceye kadar oral PGE1 alternatif bir seçenek olarak kullanılabilir. Uzun süreli kullanımda ise damar yoluna ve hastanede yatışa gerek duyulmadan, kullanımı kolay ve oldukça ucuz olan oral PGE1in intravenöz PGE1 yerine kullanılabileceğini düşünüyoruz. Ancak bunun için daha ileri çalışmalara ihtiyaç vardır.Öğe Evaluation of Oral Prostaglandin E1 in Management of Ductus Dependent Congenital Heart Disease(Cukurova Univ, Fac Medicine, 2012) Altunhan, Huseyin; Annagur, Ali; Ertugrul, Sabahattin; Konak, Murat; Sap, Fatih; Karaaslan, Sevim; Ors, RahmiPurpose: Intravenous prostaglandin E1 (PGE1) infusion is a treatment which has been proven to be effective in ductus dependent congenital heart disease. However, PGE1 is very expensive, needed continuous infusion and its supply is difficult by every center. When its long term use is necessary, these problems become more important. The aim of this study was to show whether oral PGE1could keep the ductus open or not till the supply of intravenous PGE1. Method: Ten patients, who were admitted to newborn intensive care unit with the diagnosis of ductus dependent congenital heart disease and received oral PGE1 till the supply of intravenous PGE1, were evaluated. The PO2 with the arterial blood gas analysis and SO2 levels with pulse oxymeter at skin were recorded before and after the administration of oral and intravenous PGE1. Results: The mean oral PGE1 initiation age was 5.5 hours (0.5-25), and mean administration period was 28 hours (18-46). It was observed that the PO2 and SO2 levels of patients measured 2 hours after the initiation of oral PGE1 were significantly increased compared to the levels before initiation of PGE1. The improvement in PO2 and SO2 levels continued till the initiation of intravenous PGE1. It was also observed that the PO2 and SO2 levels of patients measured 2 hours after the initiation of intravenous PGE1 were slightly increased compared to levels before initiation of intravenous PGE1. Conclusion: Although intravenous PGE1 is more effective than oral PGE1 in short term usage, oral PGE1 is also sufficiently effective in keeping the dustus open. For this reason until the intravenous PGE1 is supplied oral PGE1 may be used as an alternative treatment choice. We think that in long term use oral PGE1, which is cheaper and easy to use, could be used instead of intravenous PGE1 without need of admission to hospital and opening intravenous line. However for this further studies are needed to confirm this assumption.Öğe Hipernatremik Dehidratasyon ile İlişkili Konjenital Pilor Atrezi(2017) Tarakçı, Nuriye; Konak, Murat; Hüseyin, Altunhan; Yurtçu, Müslüm; Örs, RahmiKonjenital pilor atrezisi (KPA) oldukça nadir bir durumdur. İzole olabileceği gibi eşlik eden anomaliler de bulunabilir. İzole vakalarda prognoz iyi olup eşlik eden patolojiye bağlı olarak fatal de olabilmektedir. Etyolojisi bilinmemektedir. Ailesel vakaların literatürde bildirilmesi hastalığın genetik geçişli olabileceğini de düşündürmüştür. Bu olguda intrauterin tanısı olmayan hipernatremik dehidratasyon kliniği ile geç tanı almış bir KPA vakası nadir görülmesi nedeni ile sunulmuştur.Öğe Hiperpreksi ile Seyreden Konjenital Uzun QT Sendromu(2014) Tarakçı, Nuriye; Konak, Murat; Hüseyin, Altunhan; Alp, Hayrullah; Örs, RahmiKonjenital uzun QT sendromu (KUQTS) EKG de QT intervalinde uzama ile karakterize genetik bir hastalıktır.Ventriküler taşiaritmilere bağlı ani kardiak ölüm riski bu hastalarda yüksektir. KUQTS'da fetus intrauterin atrioventriküler blok, sinüs bradikardisi ve taşiaritminin sonucu olarak bradikardi sergileyebilir. QT mesafesindeki uzama ile birlikte sensöronöral işitme kaybı, kas paralizisi, immun yetmezlik, sindaktili gibi multisistem tutulumları bildirilmektedir. Biz burada prenatal bradikardisi olan ve postnatal KUQTS tespit edilen prematüre bir hastamızı immun yetmezlik ve enfeksiyon kliniği olmaksızın hiperpreksia eşlik etmesi ve bu durumun literatürde ilk olması nedeni ile sunduk.Öğe Hyperpyrexia Associated with Congenital Long QT Syndrome(Cukurova Univ, Fac Medicine, 2014) Tarakci, Nuriye; Konak, Murat; Altunhan, Huseyin; Alp, Hayrullah; Ors, RahmiCongenital long QT syndrome (CLQTS) is a genetic disorder presented with prolonged QT interval. In these patients, risk of sudden cardiac death due to ventricular tachyarrhythmias is high. Bradycardia may exhibit as a result of intrauterine fetal atrioventricular block, sinus bradycardia, tachycardia in these patient. Prolonged QT interval and multisystem involvement such as sensorineural hearing loss, muscle paralysis, immune deficiency, syndactyly have been reported in these patient. We have detected hyperpyrexia without clinical immunodeficiency and infection in our patient. To our knowledge, our patient is the first case in the literatureÖğe Klasik galaktozemili bir yenidoğanda Candida albicans menenjiti(2012) Altunhan, Hüseyin; Annagür, Ali; Konak, Murat; Ertuğrul, Sabahattin; Yüksekkaya, Hasan Ali; Örs, RahmiKlasik galaktozemi nadir görülen bir karbonhidrat metabolizma bozukluğudur. Galaktozemili hastalarda sepsis sıklığı belirgin derecede artmıştır. En sık görülen sepsis etkeni E. coli’dir. Mantar sepsisi galaktozemi hastalarında nadiren bildirilmiştir. Kandida sepsisi yenidoğan yoğun bakım ünitelerinde özellikle prematürite ve düşük doğum ağırlığı gibi altta yatan bir risk faktörü olan bebeklerde önemli bir sepsis nedenidir. Galaktozemi hastalarında en sık sepsis etkeni E. coli olmasına rağmen altta yatan bir risk faktörü olmasa da kandidiyazisin de bu hastalarda bir sepsis ve menenjit etkeni olabileceği akılda tutulmalıdır. Ayrıca kandidiyaziste klinik ve laboratuar bulgular silik olabilir. Bu nedenle özellikle neonatal kandida menenjitinde erken tanı ve tedavi için şüphe indeksini yüksek tutmak gerekir. Böyle hastalarda BOS analizi, kültürü ve beyin görüntülenmesi mutlaka yapılmalıdır. Çünkü erken tanı ve tedavi hayat kurtarıcı olacaktır. Bu yazıda yatışının dördüncü gününde alınan kan kültüründe Candida albicans üreyen ve menenjit tanısı konan bir klasik galaktozemi olgusu sunuldu.Öğe Konjenital nefrotik sendrom: Olgu sunumu ve literatürün gözden geçirilmesi(2012) Konak, Murat; Annagür, Ali; Altunhan, Hüseyin; Ataş, Bülent; Örs, RahmiKonjenital nefrotik sendrom (KNS), doğumdan sonra kendini belli eden ciddi proteinüri, hipoalbüminemi ve ödemle karakterize nadir bir böbrek hastalığıdır. Özellikle nefrin ve podocin adlı genlerde oluşan mutasyon sonucu glomerular filtrasyon bariyerinin bozulmasıyla ortaya çıkan genetik bir bozukluktur. KNS perinatal enfeksiyonların sonucunda olabileceği gibi, genetik bir sendromunda parçası da olabilir. İmmün süpresif tedavi genetik kaynaklı KNS'de etkisizdir ancak böbrek transplantasyonu küratif tedavi sağlamaktadır. Birçok vakada hayatı tehdit eden ödemden korumak için günlük albümin infüzyonu gerekmektedir. Ek olarak yüksek kalorili diyet, tiroksin ve mineral desteği uygulanır. Tromboembolik komplikasyonların ve immünite yetersizliğinden dolayı gelişebilecek firsatçı infeksiyonların proflaksisi gerekmektedir. Yazımızda ödemi olmayan ancak sebat eden hipoalbüminemi ve proteinüri nedeniyle KNS tanısı alan bir yenidoğan olgusunu sunarak hastalığı literatür eşliğinde tartıştık.Öğe Nadir bir neonatal menenjit etkeni: Grup A streptokok(2013) Annagür, Ali; Altunhan, Hüseyin; Ertuğrul, Sabahattin; Konak, Murat; Örs, RahmiGrup A streptokoklar neonatal menenjitin oldukça nadir etkenlerindendir. Biz literatür ışığında A grubu beta hemolitik streptokokun neden olduğu bir yenidoğan menenjit olgusunu tartıştık. Daha önce sağlıklı olan 24 günlük erkek bebek; bir gündür devam eden ateş, emmeme ve sola lokalize konvülziyonla başvurdu. Yapılan lomber ponksiyonu pürülan menenjit ile uyumluydu. Hem kan hem de beyin omurilik sıvısı kültüründe A grubu beta hemolitik streptokok üredi. Hasta Penisilin G ile tedavi edildi. Klinik seyrinde tetra ventriküler hidrosefali geliştiği gözlendi. Ancak şant takılmasına ihtiyaç duyulmadı. Takiplerinde de işitme kaybı geliştiği tespit edildi. Grup A streptokok menenjiti yenidoğan döneminde oldukça nadir görülmesine rağmen yenidoğan sepsis ve menenjit olgularında akılda bulundurulması gereken etkenlerdendir. Grup A streptokok menenjiti diğer yenidoğan menenjit etkenleri gibi ciddi nörolojik sekellere yol açabilir.Öğe Respiratory Distress in Neonatal Intensive Care Unit: A Retrospective EvaluationA(Cukurova Univ, Fac Medicine, 2012) Annagur, Ali; Altunhan, Huseyin; Aribas, Semra; Konak, Murat; Koc, Hasan; Ors, RahmiPurpose: To determine the demographic characteristics of the newborns with respiratory difficulties, frequency of neonatal disease, analyze of the prognostic factors and effectiveness of treatment who were hospitalized in neonatal intensive care unit (NICU). Methods: In this study, file records of the newborns who were hospitalized in NICU of Meram Medical School were analyzed retrospectively. Results: Of the 771 newborns, 225 who admitted due to respiratory distress in 2008 and of the 692 newborns, 282 who admitted due to respiratory distress in 2009. Mean birth weight was 1954 +/- 972 gr in 2008, and 2140 +/- 1009 gr in 2009. Mean pregnancy weeks were 32,4 +/- 5,0 in 2008 and 33,4 +/- 4,9 in 2009. Diagnosis of patients were sepsis (77,8%), respiratory distress syndrome (RDS) (40,4%), pneumothorax (20,9%), patent ductus arteriosus (PDA) ( 12,4%), meconium aspiration syndrome (MAS) (6,2%), intraventricular hemorrhage (IVH) (5,3%), pneumonia (3,6%), retinopathy of prematurely (ROP) (3,1%), bronchopulmonary dysplasia (BPD) (2,7%) and transient tachypne of newborn (TTN) (2,2%) in 2008. In 2009, percentage of the diagnosis was 69,5% sepsis, 33,3% RDS, 17,0% PDA, 16,0% pneumothorax, 10,3% pneumonia, 8,2% IVH, 6% TTN, 5,3% BPD, 3,2% MAS and 3,2% ROP. 33.7% of the patients were died in 2009 and 43,6% of them in 2008. Conclusion: The newborns with respiratory distress who admitted to the hospital must be evaluated according to the pregnancy week, way of birth and accompanying problems during first examination and convenient transportation of the ones who need to be cared in advanced center where an intensive care support can be applied to decrease mortality and morbidity of newborns distress.Öğe Role of Subgroup Incompatibility in Newborn Jaundice Requiring Exchange Transfusion(Modestum Ltd, 2014) Annagur, Ali; Altunhan, Huseyin; Konak, Murat; Koc, Hasan; Ors, RahmiWe aimed to determine the role of exchange transfusion related complications, treatment, and etiology as well as subgroup incompatibility in patients subject to ET (exchange transfusion) due to newborn jaundice. 82 patients hospitalized due to newborn jaundice and exposed to exchange transfusion between August 2007 and August 2011 were retrospectively studied. Before ET mean total serum bilirubin was 29,2 +/- 9,83. The most frequent cause of ET was ABO incompatibility (31%) followed by Rh incompatibility (19%) and subgroup incompatibility (17%), respectively. In 46% of all patients and in 71% of the patients presenting with subgroup incompatibility, direct combs test was detected to be (+). 49% of the patients were administrated with intravenous immunoglobulin. 5 of the patients who were exposed to ET presented with hydrops fetalis. Of these patients 3 had Rh, 1 had ABO while the other had subgroup incompatibility. Although ABO and Rh incompatibility are substantial underlying reasons of severe jaundice requiring exchange transfusion, particularly widespread use of RhoGAM thereby enabling the prior identification and precautions, ET need was reduced compared to previous cases. On the contrary, SGU related severe hemolytic jaundice relatively enhanced, however.Öğe Role of Subgroup Incompatibility in Newborn Jaundice Requiring Exchange Transfusion(Modestum Ltd, 2014) Annagur, Ali; Altunhan, Huseyin; Konak, Murat; Koc, Hasan; Ors, RahmiWe aimed to determine the role of exchange transfusion related complications, treatment, and etiology as well as subgroup incompatibility in patients subject to ET (exchange transfusion) due to newborn jaundice. 82 patients hospitalized due to newborn jaundice and exposed to exchange transfusion between August 2007 and August 2011 were retrospectively studied. Before ET mean total serum bilirubin was 29,2 +/- 9,83. The most frequent cause of ET was ABO incompatibility (31%) followed by Rh incompatibility (19%) and subgroup incompatibility (17%), respectively. In 46% of all patients and in 71% of the patients presenting with subgroup incompatibility, direct combs test was detected to be (+). 49% of the patients were administrated with intravenous immunoglobulin. 5 of the patients who were exposed to ET presented with hydrops fetalis. Of these patients 3 had Rh, 1 had ABO while the other had subgroup incompatibility. Although ABO and Rh incompatibility are substantial underlying reasons of severe jaundice requiring exchange transfusion, particularly widespread use of RhoGAM thereby enabling the prior identification and precautions, ET need was reduced compared to previous cases. On the contrary, SGU related severe hemolytic jaundice relatively enhanced, however.Öğe Successful Treatment of Atrial Flutter with Propafenone and Synchronized Cardioversion in a Newborn(All India Inst Medical Sciences, 2014) Konak, Murat; Alp, Hayrullah; Tarakci, Nuriye; Baysal, Tamer; Ors, Rahmi[Abstract Not Availabe]Öğe Successful use of topical Ankaferd Blood Stopper for repetitive bleedings in an infant with infantile hemangioma(E-Century Publishing Corp, 2012) Annagur, Ali; Altunhan, Huseyin; Konak, Murat; Ors, RahmiInfantile hemangioma (IH) is the most common vascular tumor of childhood. A major feature of this tumor is rapid growth during a proliferation phase in the first year of life, followed by contraction through a slow involution phase. Several complications may emerge during this course. Bleeding at the site of the lesion and infection are the most common complications. 'Ankaferd Blood Stopper' (ABS) is a hemostatic agent produced as a mixture of five separate plant extracts. Provision of hemostasis by ABS is independent from coagulation factors and the standard coagulation cascade. Furthermore, ABS has an antimicrobial effect. In this article, we have presented a seven-year-old infant with IH on the lower lip who had been admitted with the symptoms of frequent bleedings and infection, and who was successfully treated with topical ABS in terms of control of bleeding and infection. To the best of our knowledge, this is the first reported case of IH that has been treated with ABS for bleeding.Öğe Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis(Wiley, 2015) Annagur, Ali; Ors, Rahmi; Altunhan, Huseyin; Kurban, Sevil; Ertugrul, Sabahattin; Konak, Murat; Uygun, Saime SunduzBackgroundParaoxonase-1 (PON-1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high-density lipoprotein (HDL). The aim of this study was to evaluate PON-1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON-1 in neonatal sepsis treatment. MethodsA total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON-1, total oxidant state (TOS) and total antioxidant state (TAS) were measured and oxidative stress index (OSI) was calculated. ResultsIn the neonatal sepsis patients, pre-treatment TAS, TOS and OSI were significantly higher than the post-treatment levels (P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON-1 was significantly lower (P < 0.0001). Similarly, pre-treatment TAS, TOS and OSI in the sepsis group were also significantly higher than in the control group (P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON-1 was significantly lower (P < 0.0001). Post-treatment TAS in the sepsis group was significantly higher than in the control group (P = 0.009), whereas post-treatment TOS, OSI and PON-1 in the sepsis group were not significantly different to the control group (P = 0.078, P = 0.597 and P = 0.086, respectively). ConclusionLow serum PON-1 was found in neonatal sepsis. Serum PON-1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis.Öğe Total antioxidant, total oxidant and serum paraoxonase levels according to lipid administration method in parenterally fed premature infants(Taylor & Francis Ltd, 2017) Konak, Murat; Tarakci, Nuriye; Altunhan, Huseyin; Annagur, Ali; Toker, Aysun; Ors, RahmiObjective: The aim of our study was to determine whether lipid solutions delivered separately or in mixture with total parenteral nutrition (TPN) solutions effect the balance between oxidant and antioxidant levels in premature infants.Methods: A total of 60 preterm newborns who were delivered at their 30-34 gestational weeks and received TPN were included in the study. Premature newborns were randomized into two groups based on the delivery method of the lipid solution, separately (Group 1) or in mixture with TPN solutions (Group 2). Total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase (PON-1) levels were analyzed in both blood samples, and oxidative stress index (OSI) was also calculated.Results: Thirty cases from both groups were included in the study. Statistically significant decrease in the level of TAS and increase in the level of PON-1 were detected at 72h of TPN therapy in both groups (p<0.05). Statistically significant decrease in both TOS and OSI levels were observed in Group 2 (p<0.05). In association with these findings, any statistically significant intergroup difference was not detected in both parameters regarding oxidant balance (p>0.05).Conclusion: Our study showed that according to lipid administration method any difference for oxidant-antioxidant balance was not detected.Öğe Total oxidant, antioxidant, and paraoxonase levels in babies born to pre-eclamptic mothers(Wiley, 2013) Altunhan, Huseyin; Annagur, Ali; Kurban, Sevil; Ertugrul, Sabahattin; Konak, Murat; Ors, RahmiAim The aim of this study was to investigate the oxidant-antioxidant status in babies born to pre-eclamptic mothers (BBPM). Material and Methods The paraoxonase (PON)-1, total antioxidant status (TAS), and total oxidant status (TOS) levels were measured in the cord blood and venous blood (7th day) of BBPM (n=31) and babies born to normotensive mothers (n=25). Results The PON-1 and TOS levels in the cord blood and venous blood on the 7th day were not significantly different between the two groups; however, the cord blood TAS levels were higher in BBPM (P=0.001), and the TAS levels in the venous blood were higher in the control group (P=0.021). Furthermore, the cord blood PON-1 levels of babies born to severely pre-eclamptic mothers (n=18) were higher than those of babies born to moderately pre-eclamptic mothers (n=13) (P=0.042). There were no differences in the cord blood TAS and TOS levels and venous blood PON-1, TAS, and TOS levels between babies born to severely and moderately pre-eclamptic mothers. Conclusion The increased TAS levels found in the cord blood of BBPM indicate that the fetus is protected against oxidative damage caused by increased oxidative stress in the mother. To the best of our knowledge, this is the first study in the published work investigating PON-1 levels in BBPM.Öğe Yenidoğan yoğun bakım ünitesine solunum sıkıntısı nedeniyle yatan hastaların retrospektif olarak değerlendirilmesi(2012) Annagür, Ali; Altunhan, Hüseyin; Arıbaş, Semra; Konak, Murat; Koç, Hasan; Örs, RahmiAmaç: Yenidoğan Yoğun Bakım Ünitesine solunum sıkıntısı nedeniyle yatan hastaların demografik özelliklerini ve solunum sıkıntısına neden olan yenidoğan hastalıklarının sıklığını, tedavinin etkinliğini ve prognozunu belirlemektir. Gereç ve yöntemler: Bu çalışmada 01.01.2008 ile 31.12.2009 tarihleri arasında Meram Tıp Fakültesi Yenidoğan Yoğun Bakım Ünitesine solunum sıkıntısı nedeni ile yatırılarak izlenen hastaların dosya kayıtları retrospektif olarak incelendi. Bulgular: 2008 yılında 771, 2009 yılında ise 692 hasta yatırılarak takip ve tedavi edildi. Bu hastalardan 2008 yılında 225'i, 2009 yılında 282'si solunum sıkıntısı nedeni ile başvurdu. Ortalama doğum ağırlığı 2008'de 1954972 gr, 2009'da 21401009 gramdı. Ortalama gebelik haftası 2008'de 32,45,0 hf, 2009'da 33,44,9 haftaydı. 2008 yılında aldıkları tanılar %77,8 sepsis, %40,4 respiratuar distres sendromu (RDS), %20,9 pnömotoraks, %12,4 patent duktus arteriozus (PDA), %6,2 mekonyum aspirasyon sendromu (MAS), %5,3 intra ventriküler kanama (İVK), %3,6 pnömoni, %3,1 prematüre retinopatisi (ROP), %2,7 bronkopulmoner displazi (BPD), %2,2 yenidoğanın geçici taşipnesi (YDGT) idi. 2009'da ise %69,5 sepsis, %33,3 RDS, %17,0 PDA, %16,0 pnömotoraks, %10,3 pnömoni, %8,2 İVK, %6 YDGT, %5,3 BPD, %3,2 MAS, %3,2 ROP tanıları aldılar. Solunum sıkıntısı nedeni ile başvuran hastaların 2008'de %43,6'sı, 2009'da %33,7'si ölümle sonuçlandı. Sonuç: Solunum güçlüğü ile başvuran yenidoğanların ilk değerlendirilmelerinde doğum haftası, doğum şekli ve eşlik eden sorunların göz önünde bulundurulması ve gereken hastaların yoğun bakım desteğinin yapılabileceği ileri bir merkeze uygun bir biçimde naklinin yapılması ile yenidoğan ölümlerinde ve morbiditesinde azalma sağlanabileceği kanısındayız.
