Total oxidant, antioxidant, and paraoxonase levels in babies born to pre-eclamptic mothers
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim The aim of this study was to investigate the oxidant-antioxidant status in babies born to pre-eclamptic mothers (BBPM). Material and Methods The paraoxonase (PON)-1, total antioxidant status (TAS), and total oxidant status (TOS) levels were measured in the cord blood and venous blood (7th day) of BBPM (n=31) and babies born to normotensive mothers (n=25). Results The PON-1 and TOS levels in the cord blood and venous blood on the 7th day were not significantly different between the two groups; however, the cord blood TAS levels were higher in BBPM (P=0.001), and the TAS levels in the venous blood were higher in the control group (P=0.021). Furthermore, the cord blood PON-1 levels of babies born to severely pre-eclamptic mothers (n=18) were higher than those of babies born to moderately pre-eclamptic mothers (n=13) (P=0.042). There were no differences in the cord blood TAS and TOS levels and venous blood PON-1, TAS, and TOS levels between babies born to severely and moderately pre-eclamptic mothers. Conclusion The increased TAS levels found in the cord blood of BBPM indicate that the fetus is protected against oxidative damage caused by increased oxidative stress in the mother. To the best of our knowledge, this is the first study in the published work investigating PON-1 levels in BBPM.
Açıklama
Anahtar Kelimeler
Antioxidant Activity, Newborn, Oxidative Stress, Paraoxonase-1, Total Antioxidant Status, Total Oxidant Status
Kaynak
Journal Of Obstetrics And Gynaecology Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
39
Sayı
5
