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Öğe Assessment of the effectiveness of platelet rich fibrin in the treatment of Schneiderian membrane perforation(Wiley, 2017) Oncu, Elif; Kaymaz, EsinBackgroundThe objective of this study is to evaluate the effect of Platelet rich fibrin (PRF) treatment of maxillary sinus membrane perforation on bone formation and new vascular supply and the success of dental implant survival rate. MethodsThe dataset for this retrospective study consists of patients who received sinus augmentation using the lateral wall technique. A total of 16 patients (20 sinuses) the patients without sinus membrane perforation (10 maxiller sinus area with sinus floor augmentation) and with Schneiderian perforation (10 maxiller sinus area repairing with PRF and augmented sinus floor area) were included in this study. The bone height was measured by comparing the preoperative and postoperative dental CBCT scans. Histological sections were evaluated for possible vasculogenesis augmented sinuses area. ResultsIn both groups, it was observed that the possible vasculogenesis augmented sinuses area increased. Implant survival rates in both groups found that one hundred percent and any bone loss around implants were not observed. An apparent increase in alveolar bone height was observed and measured in CBCT scans. ConclusionsPRF can be considered as an alternative material for repairing sinus perforations because it is fully autogenous and easy manipulated.Öğe Combined use of alveolar distraction osteogenesis and segmental osteotomy in anterior vertical ridge augmentation(Elsevier Sci Ltd, 2015) Oncu, Elif; Isik, Kubilay; Alaaddinoglu, E. Emine; Uckan, SinaINTRODUCTION: Vertical defects of the anterioral veolar ridge are challenging cases in implant dentistry. Various techniques, such as onlay bone grafting, segmental osteotomy (SO) oral veolar distraction osteogenesis (ADO), have been suggested to manage those situations. ADO has an advantage of being capable of enhancing both hard and soft tissue simultaneously. PRESENTATION OF CASE: One of the possible complications of ADO is rotation ortilting the transport segment (TS). In this report, we present a 30-year old woman who had a severe anterior vertical deficiency. ADO was started to manage the case, but advancement of the TS lagged on the left side and the segment rotated. A SO was planned and the lagged side was corrected. Two years after the surgery, hard and soft tissue gains were found to be preserved. DISCUSSION: Vertical alveolar bone deficiencies are challenging cases for dental implantology. Alveolar DO promotes soft tissue along with hard tissue, and the bone regeneration process and shows lower infection rates and greater stability over the long term. However, the technique has some disadvantages and can lead to complications, such as breaking of the distraction device, nerve injury or paresthesia, fracture of transport bone, hematoma, wound dehiscence, severe bleeding, and even jaw fractures. Deviation of the TS from the distraction path is another undesired situation. The rigidity of the device, the width of the mucosa, the volume of the transport and anchor segments, and the amount of augmentation can affect vector deviation. CONCLUSION: We suggest that SO can be used in similar cases in which TS could not be distracted on a straight vector line. (C) 2015 Published by Elsevier Ltd. on behalf of Surgical Associates Ltd.Öğe Comparison of cone-beam computed tomography and digital panoramic radiography for detecting peri-implant alveolar bone changes using trabecular micro-structure analysis(Korean Acad Oral & Maxillofacial Surgery, 2022) Magat, Guldane; Oncu, Elif; Ozcan, Sevgi; Orhan, KaanObjectives: We compared changes in fractal dimension (FD) and grayscale value (GSV) of peri-implant alveolar bone on digital panoramic radiograph (DPR) and cone-beam computed tomography (CBCT) immediately after implant surgery and 12 months postoperative. Materials and Methods: In this retrospective study, 16 patients who received posterior mandibular area dental implants with CBCT scans taken about 2 weeks after implantation and one year after implantation were analyzed. A region of interest was selected for each patient. FDs and GSVs were evaluated immediately after implant surgery and at 12-month follow-up to examine the functional loading of the implants. Results: There were no significant differences between DPR and CBCT measurements of FD values (P>0.05). No significant differences were observed between FD values and GSVs calculated after implant surgery and at the 12-month follow-up (F50.05). GSVs were not correlated with FD values (P>0.05). Conclusion: The DPR and reconstructed panoramic CBCT images exhibit similar image quality for the assessment of FD. There were no changes in FD values or GSVs of the pen-implant trabecular bone structure at the 12-month postoperative evaluation of the functional loading of the implant in comparison to values immediately after implantation. GSVs representing bone mass do not align with FD values that predict bone microstnictural parameters. Therefore, GSVs and Ws should be considered different parameters for assessing bone quality.Öğe Comparison of Osteoimmunological and Microbiological Parameters of Extra Short and Longer Implants Loaded in the Posterior Mandible: A Split Mouth Randomized Clinical Study(Univ Zagreb, Sch Dental Medicine, 2021) Karci, Bilge; Oncu, ElifObjectives: This study aimed to evaluate the levels of TNF-alpha, PGE., RANKL, RANK, OPG, the markers of periimplant bone toss in peri-implant crevicutar fluid obtained around standard and extra short implants. Moreover, the levels of putative oral pathogens were investigated in the submucosal biofilm samples. Material and Methods: The implants were divided into two groups according to their Lengths: standard (>= 8 mm) and extra short (4 mm). A total of 60 implants were researched in 30 patients. The probing depth (PD), clinical attachment level (CAL), presence of bleeding on probing (BOP), 3-year survival rate (CSR), and bone toss (BL) were measured. Results: No statistically significant difference was found in the values of PD, CAL, BOP, CSR, and BL between the groups (P> 0.05). Total amounts of PGE,, RANKL, RANK, OPG, and RANKL/OPG were not statistically significantly different between the groups (P> 0.05). The abundance of F. nucleatum, T. forsythia, P. intermedia, P. gingivalis, S. oralis and T. denticola was compared between the groups and the results were not statistically significant (P> 0.05). Conclusion: The results of this study suggested that PGE(2), TNF-alpha, RANKL, RANK, OPG, and RANKL/OPG in PICF, as well as microbiological parameters in submucosal biofilms, were similar between standard (>= 8 mm) and extra short (4 mm) implants. Therefore, the implant length does not seem to influence the bone loss, levels of osteoimmunological and microbiological markers in the peri-implant tissues and survival rates.Öğe Comparison of Osteoimmunological and Microbiological Parameters of Extra Short and Longer Implants Loaded in the Posterior Mandible: A Split Mouth Randomized Clinical Study(Univ Zagreb, Sch Dental Medicine, 2021) Karci, Bilge; Oncu, ElifObjectives: This study aimed to evaluate the levels of TNF-alpha, PGE., RANKL, RANK, OPG, the markers of periimplant bone toss in peri-implant crevicutar fluid obtained around standard and extra short implants. Moreover, the levels of putative oral pathogens were investigated in the submucosal biofilm samples. Material and Methods: The implants were divided into two groups according to their Lengths: standard (>= 8 mm) and extra short (4 mm). A total of 60 implants were researched in 30 patients. The probing depth (PD), clinical attachment level (CAL), presence of bleeding on probing (BOP), 3-year survival rate (CSR), and bone toss (BL) were measured. Results: No statistically significant difference was found in the values of PD, CAL, BOP, CSR, and BL between the groups (P> 0.05). Total amounts of PGE,, RANKL, RANK, OPG, and RANKL/OPG were not statistically significantly different between the groups (P> 0.05). The abundance of F. nucleatum, T. forsythia, P. intermedia, P. gingivalis, S. oralis and T. denticola was compared between the groups and the results were not statistically significant (P> 0.05). Conclusion: The results of this study suggested that PGE(2), TNF-alpha, RANKL, RANK, OPG, and RANKL/OPG in PICF, as well as microbiological parameters in submucosal biofilms, were similar between standard (>= 8 mm) and extra short (4 mm) implants. Therefore, the implant length does not seem to influence the bone loss, levels of osteoimmunological and microbiological markers in the peri-implant tissues and survival rates.Öğe The Effect of Different Dental Implant Surface Characteristics on Bone Immunologic Biomarkers and Microbiologic Parameters: A Randomized Clinical Study(Quintessence Publishing Co Inc, 2021) Karci, Bilge; Oncu, Elif; Dogan, MetinThis study assessed the levels of tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANKL), osteoprotegerin (OPG), and levels of Fusobacterium nucleatum, Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Prevotella intermedia, and Streptococcus oralis in areas where airborne particle-abraded, large-grit, acid-etched (SLA), fluorine-modified, and anodized implant surfaces are used. A total of 71 implants from 37 patients were assessed, grouped according to the surface characteristics of the implants: SLA surface (Group 1), fluorine-modified surface (Group 2), and anodized surface (Group 3). The following clinical indices were measured: Gingival Index (GI), probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), and keratinized tissue width (KTW). Peri-implant sulcus fluid and subgingival plaque samples were also collected. Commercial enzyme-linked immunosorbent assay (ELISA) kits were purchased for measuring TNF-alpha, PGE2, RANKL, RANK, and OPG. Real-time quantitative polymerase chain reaction (PCR) was used to detect P intermedia, T forsythia, T denticola, F nucleatum, P gingivalis, and S oralis levels in the subgingival biofilms. The groups showed no statistically significant differences in GI, PD, BOP, CAL, KTW, or peri-implant status. The total amounts of PGE2, TNF-alpha, RANKL, RANK, and OPG and the RANKL/OPG ratio were not significantly different between groups. F nucleatum, T forsythia, P intermedia, P gingivalis, and T denticola were significantly higher in Group 3 implants. DNA concentrations of S oralis were higher in Group 2. Within the limitations of this study, SLA and fluorine-modified implant surfaces may be more clinically successful than anodized-surface implants.Öğe Effect of Maxillary Sinus Anatomy on Bone Gain After Lateral Window Sinus Floor Elevation: A Case-Control Study(Quintessence Publishing Co Inc, 2023) Babayigit, Osman; Oncu, Elif; Magat, Gueldane; Orhan, KaanPurpose: To evaluate the effect of maxillary sinus anatomy on sinus floor elevation (SFE) operations performed with the lateral window approach. Materials and Methods: CBCT and digital panoramic radiographs were evaluated before and at least 6 months after maxillary sinus floor elevation (SFE) operations performed in 33 maxillary sinus regions in 26 patients. Maxillary sinus volume, grafted volume (GV), sinus width (SW), residual bone height (RBH), and vertical graft resorption (VGR) were calculated. The effects of RBH and SW on GV and VGR were evaluated statistically. Results: The mean GV values in the maxillary sinuses classified as narrow, average, and wide were 2.60 & PLUSMN; 0.57, 3.44 & PLUSMN; 0.65, and 3.70 & PLUSMN; 0.64 cm3, respectively. The mean VGR was 2.12 & PLUSMN; 1.67 mm, and in the sites classified as narrow, average, and wide, the mean VGR values were 1.50 & PLUSMN; 0.79, 1.58 & PLUSMN; 1.28, and 3.46 & PLUSMN; 2.06 mm, respectively. A statistically significant difference in GV and VGR was found between the SW groups. The mean posterior maxillary RBH was 2.30 & PLUSMN; 1.05 mm, and 17 and 16 sinuses were classified as & LE; 2 and > 2 mm, respectively. There was no statistically significant difference in the effect of RBH on GV or VGR. Conclusion: Although posterior maxillary RBH did not affect new bone formation in the sinuses grafted only with hydroxyapatite-derived inorganic bovine bone, with increasing SW, the GV decreased and the VGR increased.Öğe The Effect of Platelet-Rich Fibrin on Implant Stability(Quintessence Publishing Co Inc, 2015) Oncu, Elif; Alaaddinoglu, E. EminePurpose: Achieving accelerated implant osseointegration could make immediate or early loading of implants more predictable. Platelet-rich fibrin (PRF) is frequently used to accelerate soft and hard tissue healing. The activated platelets in PRF release growth factors, resulting in cellular proliferation, collagen synthesis, and osteoid production. The aim of this study was to compare the stability of dental implants inserted in a one-stage surgical protocol with or without PRF application. Materials and Methods: Twenty healthy patients with adequate alveolar bone and two or more adjacent missing teeth extracted at least 6 months previously were included in this study. A minimum of two tapered implants (Ankylos, Dentsply/Friadent) were placed in each patient. After surgical preparation of the implant sockets, PRF that had been prepared preoperatively was placed randomly into one of the sockets (PRF+). The acellular plasma portion of PRF was used to wet the implant placed into the PRF-coated socket. Resonance frequency measurements were made after implant placement and at 1 week and 1 month postoperatively. Results: Mean implant stability quotients (ISQs) of the PRF+ implants was 69.3 +/- 10.5, and mean ISQs for the PRF-implants was 64.5 +/- 12.2 at the end of the first week. The mean ISQs at 4 weeks postoperatively were 77.1 +/- 7.1 for the PRF+ group and 70.5 +/- 7.7 for the PRF-group. Conclusion: In this study, PRF application increased implant stability during the early healing period, as evidenced by higher ISQ values. Simple application of this material seems to provide faster osseointegration.Öğe Effects of different desensitizers and lasers on dentine tubules: An in-vitro analysis(Wiley, 2017) Oncu, Elif; Karabekiroglu, Said; Unlu, NimetBackgroundDentin hypersensitivity is an important clinical problem affecting a large percentage of the population, and various therapies have been suggested for its treatmentamong them desensitizing agents and lasers. The aim of this study was to evaluate the in vitro effects of different in-office desensitizing agents and different type lasers, alone or in combination, on human dentinal tubules. Materials and MethodsEighty-four dentinal specimens obtained from freshly extracted impacted third molars were included and subsequently divided into seven groups: Group 1 (Control), Group 2 (Gluma desensitizer), Group 3 (Teethmate desensitizer), Group 4 (Nd:YAG laser), Group 5 (Er:YAG laser), Group 6 (Gluma desensitizer+Er:YAG laser), and Group 7 (Teethmate desensitizer+Er:YAG laser). The dentinal specimens of all groups were evaluated using SEM. A total of 12 images per sample were taken, and the numbers of open, partially occluded, and totally visible (open+partially occluded) dentinal tubules were counted. AFM was used to further substantiate the blocking mechanism. The data were analyzed by one-way ANOVA and Dunnett-C tests. ResultsComparison of the number of occluded dentinal tubules per 100 mu m(2) revealed that the laser and laser combined-treated groups showed the most occluded dentinal tubules. Gluma desensitizer+Er:YAG laser combination demonstrated significantly more tubule occlusion than all the other groups (p<.05). ConclusionsThe results of this study show that combined treatment methods were effective in the occlusion of dentinal tubules.Öğe Enhancement of Immediate Implant Stability and Recovery Using Platelet-Rich Fibrin(Quintessence Publishing Co Inc, 2019) Oncu, Elif; Erbeyoglu, Ahmet AfsinThe objective of this study was to evaluate the effect of leukocyte platelet-rich fibrin (L-PRF) on immediate implant stability and recovery. A total of 60 immediate implants were evaluated. After the extraction, using split-mouth design, test sockets were coated with L-PRF (L-PRF+) and control sockets were not (L-PRF). All the implants were followed for 12 months. Results showed a statistically significant difference between the stability of L-PRF+ and L-PRF - implants at 1 week and at 1 month. Mean marginal bone resorption was higher in the control group at 1 year.Öğe EVALUATION OF RELATIONSHIP BETWEEN GINGIVAL PHENOTYPE AND PERIODONTAL STATUS(Jadoun Science Publishing Group, 2022) Babayigit, Osman; Yarkac, Fatma Ucan; Atay, Ummuhan Tekin; Sen, Dilek Ozkan; Oncu, ElifDetermining the gingival phenotype and knowing its relationship with clinical periodontal parameters is critical in terms of guiding the clinician and the treatment results. The present study evaluated the prevalence of gingival phenotype and its relationship with crown shape, papilla height (PH), keratinized tissue width (KTW), and risk factors. A total of 90 individuals, 53 females and 37 males were included in the study. Based on the transparency of a periodontal probe through the buccal gingival margin, was determined thin phenotype and thick phenotype groups. Sociodemographic data, oral hygiene status and clinical periodontal parameters, supracrestal gingival height (SGH), crown width/crown length ratio, PH, and KTW were evaluated. No statistical difference (p>0.05) was detected neither for the correlation between different phenotypes (thick/thin) and SGH nor for associating phenotypes and crown width/crown length ratio. Additionally, there was no statistically significant difference in periodontal parameters and PH between thick and thin phenotype groups (p>0.05). PH was higher for individuals with rectangular crown shapes compared to individuals with square crown shapes (p<0.05). It was found that the prevalence of rectangular and square crown shapes was equal and the thick gingival phenotype was higher in the Turkish population. There was no correlation between the gingival phenotype and crown shape, periodontal parameters, and papilla heights. It has been shown that individuals with a thick phenotype have higher KTW and the shape of the crown in the anterior region of the maxilla affects the height of the papilla. Copyright (C) 2013 - All Rights Reserved - PharmacophoreÖğe Intraoral and maxillofacial abnormalities in patients with autosomal dominant hyper-IgE syndrome(Termedia Publishing House Ltd, 2023) Tar, Ildiko; Szegedi, Marta; Krasuska-Slawinska, Ewa; Heropolitanska-Pliszka, Edyta; Bernatowska, Ewa a.; Oncu, Elif; Keles, SevgiAutosomal dominant hyper-IgE syndrome (AD-HIES) is an inborn error of immunity (IEI) caused by a dominant-negative mutation in the signal transducer and activator of transcription 3 (STAT 3). This disease is characterized by chronic eczematoid dermatitis, recurrent staphylococcal skin abscesses, pneumonia, pneumatoceles, and extremely high serum IgE levels. Loss-of-function STAT3 mutations may also result in distinct non-immunologic features such as dental, facial, skeletal, and vascular abnormalities, central nervous system malformations and an increased risk for bone fractures. Prophylactic treatment of Candida infections and prophylactic antimicrobial therapy for staphylococcal skin infections and sinopulmonary infections are essential. An awareness of the oral and maxillofacial features of HIES may facilitate early diagnosis with genetic counselling and may improve future patient care. This study describes oral, dental, and maxillofacial manifestations in 14 patients with genetically defined AD-HIES. We also review the literature and propose recommendations for the complex care of patients with this rare primary immunodeficiency.Öğe Positive effect of platelet rich fibrin on osseointegration(Medicina Oral S L, 2016) Oncu, Elif; Bayram, Burak; Kantarci, Alpdogan; Gulsever, Serap; Alaaddinoglu, Emine-ElifBackground: Leukocyte-platelet rich fibrin (L-PRF) is a second generation platelet concentrate clinically used to accelerate tissue healing and bone regeneration. Achieving reduced implant osseointegration time could provide immediate or early loading of implants. The aim of this study was to evaluate the L-PRF-induced osseointegration and bone-implant contact (BIC) in an experimental animal model. Material and Methods: Twelve 4-month-old New Zealand white rabbits were used. Following general anesthesia, 3-5 mL of blood was obtained from the central artery in rabbit ear and L-PRF was prepared. Two implant cavities (5 mm long and 3 mm in diameter) were created in each tibia with a total of four cavities in each animal. Two of these cavities were selected and covered with PRF (test group). The remaining L-PRF was used to soak the implants placed into the L-PRF covered sockets. Other cavities were left as controls. In total, 48 implants were placed. Animals were sacrificed after two, three, or four weeks. Histological samples were obtained and peri-implant tissues were histomorphometrically evaluated for bone-to-implant contact and new bone formation. Results: Histomorphometric analyses of the defects revealed that the L-PRF was detectable up to the second week. Application of L-PRF increased the rate and amount of new bone formation in the experimental group compared to the control group. Bone-to-implant contact was enhanced when the surface was pre-wetted with L-PRF (p<0.01). Conclusions: The results of this study demonstrated that L-PRF application may increases amount and rate of new bone formation during the early healing period and provides a faster osseointegration around implants.Öğe Shear bond strength to enamel and failure type of different periodontal splints: an in vivo and in vitro study(Taylor & Francis Ltd, 2017) Karabekiroglu, Said; Oncu, Elif; Yildiz, Merve; Unlu, NimetThe goal of this study was to evaluate the shear bond strength (SBS) and failure mode of four different splint materials [Polyethylene FRC Ribbond Thm (RB), Polyethylene FRC Construct (Kerr), Multifilament Fishing Line (MFL), and Non Fiber Reinforced Composite (control)]. Thirty- seven subjects were randomly divided into four splint methods. After splinting procedures, the subjects were recalled 12 months later. One hundred and sixty human mandibular incisors (for extracoronal and intracoronal splinting) and 40 sheep mandibles (only extracoronal splinting) were used for the in vitro part. The specimens were subjected to SBS at their incisoproximal contact, and debonding forces were measured with a universal testing machine (1 mm/min crosshead speed). Failure sites were examined under a stereomicroscope (x40 magnification). The SBS data were assessed via analysis of variance (ANOVA) and Tukey's tests. The survival rate was significantly affected by the splint type (RB: 95.3%, Kerr: 91.6%, MFL: 93.5%, Control: 52.5%). No statistically significant differences were found between RB, Kerr, and MFL (p > 0.05) at all in vitro parts. Intracoronal splinting showed lower SBS values than extracoronal (p < 0.05). Lower SBS values were obtained in sheep teeth than human teeth (p < 0.05). Significantly different fracture patterns were noted between groups (p < 0.05). Only resin composite application seems to be inadequate for periodontal splinting. MFL splints are also economic and quite resistant, and they might be used as an alternative to fiber- reinforced composites.Öğe Splith mouth randomized control trial comparison of T-PRF and subepithelial connective tissue graft in the treatment of maxillar multiple gingival recessions(Wiley, 2023) Sen, Dilek Ozkan; Oncu, ElifAimThe aim of this study is to compare the treatment efficacy of the bilateral multiple gingival recession areas with a titanium-platelet-rich-fibrin (T-PRF) and subepithelial connective tissue graft (SCTG) combined with a modified coronal advanced flap (MCAF) and the clinical results. MethodIn the study, 118 maxillary bilateral multiple Miller I recessions were treated. Gingival index, plaque index, probing pocket depth, gingival thickness, recession height, recession width, keratinized gingival width and open root surface area were measured at baseline and at 6 months. Postoperative pain levels Visual Analog Scale, healing status, wound healing index evaluated with. The results of both groups pre and postoperative were compared. ResultsThe initial recession height was 2.15 +/- 1.0 mm in the T-PRF group; 2.04 +/- 0.80 mm in the SCTG group. After 6 months, the mean root closure rate was 61.77%, 75.31% in T-PRF and SCTG group, respectively. Clinical attachment gain was achieved in both groups compared to baseline. When the results were compared, the gains achieved in the SCTG group were statistically significantly higher. It was determined that patient satisfaction was higher in T-PRF group and wound healing was faster. ConclusionConsidering the advantages of T-PRF such as providing effective results in the treatment of defects, patient satisfaction and rapid recovery; It can be applied as an alternative to SCTG. Clinical SignificanceT-PRF can be an alternative to SCTG in the treatment of gingival recessions.Öğe The Use of Platelet-Rich Fibrin Versus Subepithelial Connective Tissue Graft in Treatment of Multiple Gingival Recessions: A Randomized Clinical Trial(Quintessence Publishing Co Inc, 2017) Oncu, ElifThe objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin (PRF) membrane used in combination with a modified coronally advanced flap (MCAF) and to compare it with the use of a subepithelial connective tissue graft (SCTG) in combination with a MCAF in treatment of Miller Class I and II bilateral multiple gingival recessions. A total of 20 patients with multiple Miller Class I and II maxillary gingival recession defects participated in this randomized, split-mouth, controlled study. A total of 60 defects received either PRF + MCAF (test group, n = 30) or MCAF with SCTG (control group, n = 30). Gingival recession depth (RD), keratinized tissue width (KTW), probing depth (PD), clinical attachment level (CAL), and gingival thickness (GT) were evaluated at baseline and after 6 months. Patients' discomfort postsurgery was measured by comparing visual analog scale scores. The percentage of root coverage was 84% in the control group and 77.12% in the test group (P = .007). Complete root coverage of the control and test groups was 60% and 50%, respectively (P = .112). KTW and GT increased in both groups from baseline to 6 months (P < .001). At 6 months postoperative, KTW was greater in the control group (P = .024) and GT was higher in the test group (P = .005). Use of a PRF membrane in gingival recession treatment decreased postoperative discomfort compared to SCTG-treated gingival recessions (P < .001). Within the limitations of the present study, it was concluded that localized gingival recessions could be successfully treated with MCAF + PRF as well as MCAF + SCTG. The PRF technique has the bonus advantage of being more comfortable during the postoperative period. The author suggests that the use of PRF is a valid alternative to SCTG for the treatment of localized gingival recessions.
