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    Effect of Human Papillomavirus Subtype on the Rate of Positive Surgical Margin After Cervical Conization
    (Sage Publications Inc, 2023) Purut, Yunus Emre; Giray, Burak; Akis, Serkan; Peker, Esra Keles; Babayeva, Gulchin; Kabaca, Canan; Api, Murat
    Objective. Human papillomavirus (HPV) infection is a risk factor for cervical carcinoma. Over 100 types of HPV have been identified. The excisional procedures are recommended for women with high-grade cervical intraepithelial neoplasia. Surgical margin status is an important predictor of the risk of relapse. The aim of the current study was to evaluate whether HPV genotype is a predictive factor of positive surgical margin after cervical cone excision. Materials and Methods. The records of 448 HPV-infected patients who underwent loop electrosurgical excision or cold knife conization at a tertiary gynecological cancer center were retrospectively reviewed. The patients were divided into 6 groups according to HPV positivity: HPV 16 only, HPV 18 only, HPV 16/18, other high-risk HPV (hrHPV), HPV 16/hrHPV, and HPV 18/hrHPV. Results. There was no significant difference between the HPV groups in terms of age, parity, menopausal status, endocervical canal involvement, conization method, and the rates of positive margin (P = .15, P = .49, P = .07, P = .20, P = .24, P = .39, respectively). Conclusion. The results show that HPV subtypes might not be associated with endocervical canal involvement and the rates of positive margin. In addition, margin status was not related to the conization method and the number of excised cervical tissue.
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    The Effect of Video Assisted Information on Anxiety and Pain Associated with Intrauterine Device Insertion
    (Karger, 2020) Eric, Jule; Purut, Yunus Emre; Harmanci, Hatice
    Introduction: Fear of procedural pain or stress may be a barrier to women accessing intrauterine device (IUD) for contraception. The aim of this study is to evaluate the effect of video-assisted information on the anxiety and pain levels of patients undergoing IUD placement procedure. Methods: A total of 100 patients who underwent IUD insertion were prospectively enrolled in this observational case-control study. Study group included 50 patients who received both verbal and video-based information, while control group included 50 patients who received only verbal information regarding IUD insertion. The anxiety of the participants was measured by Spielberger's State-Trait Anxiety Inventory (STAI) scale, both before and after the IUD insertion. State Anxiety Scale (STAI-S) was used to evaluate the current anxiety levels, and Trait Anxiety Scale (STAI-T) was used to evaluate the general and stable aspects of anxiety. Pain was measured using visual analog scale (VAS) immediately after the IUD insertion procedure. Results: There was no statistically significant difference between the pre-intervention STAI-S and STAI-T scores between the study and control groups (p = 0.098 for STAI-S, p = 0.641 for STAI-T). Similarly, there was no statistically significant difference between the post-intervention STAI-S score between the groups (p = 0.381). However, pain scores measured by VAS were significantly lower in the study group when compared with the control group (p < 0.001). Conclusion: Video-assisted information about IUD insertion did not have a reducing effect on anxiety, but was associated with a statistically significant decrease in pain.
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    Endometrial CD56+natural killer cells in women with recurrent implantation failure: An immunohistochemical study
    (Galenos Yayincilik, 2020) Babayeva, Gulchin; Purut, Yunus Emre; Giray, Burak; Oltulu, Pembe; Alakus, Rabia; Colakoglu, Mehmet Cengiz
    Objective: Implantation failure is a multifactorial problem of reproductive medicine. However, the mechanism of this process is still not fully understood. There is increasing evidence that these cases of recurrent implantation failure might have an immunologic background. Uterine natural killer (NK) cells provide immune-modulation at the interface between maternal decidua and the trophoblast. The aim of this study to evaluate whether there was a significant difference in the number of endometrial CD56+ NK between women with a history of recurrent implantation failure and women who had a live birth. Materials and Methods: Patients with a history of recurrent implantation failure were included in the study. Twenty-five women with a history of recurrent implantation failure were assigned to the case group, and 25 women who had one or more live births were assigned to the control group. Endornetrial biopsies were obtained during the luteal phase on the 21st-24th clay of the menstrual cycle. Results: There was a statistically significant difference between the groups concerning the number of deliveries (p<0.001) and miscarriages (p<0.001). The mean number of uNK was 10.5 +/- 10.5 cells/mm(2) in the case group and 19.2 +/- 11.2 cells/mm(2) in the control group. There was a statistically significant difference between the two groups (p=0.003). Conclusion: Implantation failure is a multifactorial problem of reproductive medicine. The results of our study suggest that uterine NK play a role in the progress of normal pregnancy and reduced uterine NK cell numbers were associated with implantation failure.