Endometrial CD56+natural killer cells in women with recurrent implantation failure: An immunohistochemical study
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayincilik
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Implantation failure is a multifactorial problem of reproductive medicine. However, the mechanism of this process is still not fully understood. There is increasing evidence that these cases of recurrent implantation failure might have an immunologic background. Uterine natural killer (NK) cells provide immune-modulation at the interface between maternal decidua and the trophoblast. The aim of this study to evaluate whether there was a significant difference in the number of endometrial CD56+ NK between women with a history of recurrent implantation failure and women who had a live birth. Materials and Methods: Patients with a history of recurrent implantation failure were included in the study. Twenty-five women with a history of recurrent implantation failure were assigned to the case group, and 25 women who had one or more live births were assigned to the control group. Endornetrial biopsies were obtained during the luteal phase on the 21st-24th clay of the menstrual cycle. Results: There was a statistically significant difference between the groups concerning the number of deliveries (p<0.001) and miscarriages (p<0.001). The mean number of uNK was 10.5 +/- 10.5 cells/mm(2) in the case group and 19.2 +/- 11.2 cells/mm(2) in the control group. There was a statistically significant difference between the two groups (p=0.003). Conclusion: Implantation failure is a multifactorial problem of reproductive medicine. The results of our study suggest that uterine NK play a role in the progress of normal pregnancy and reduced uterine NK cell numbers were associated with implantation failure.
Açıklama
Anahtar Kelimeler
Cd56, Immunohistochemistry, In Vitro Fertilization, Recurrent Implantation Failure, Uterine Natural Killer Cells
Kaynak
Turkish Journal Of Obstetrics And Gynecology
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
17
Sayı
4
