Endometrial CD56+natural killer cells in women with recurrent implantation failure: An immunohistochemical study

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dc.contributor.authorBabayeva, Gulchin
dc.contributor.authorPurut, Yunus Emre
dc.contributor.authorGiray, Burak
dc.contributor.authorOltulu, Pembe
dc.contributor.authorAlakus, Rabia
dc.contributor.authorColakoglu, Mehmet Cengiz
dc.date.accessioned2024-02-23T14:38:20Z
dc.date.available2024-02-23T14:38:20Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjective: Implantation failure is a multifactorial problem of reproductive medicine. However, the mechanism of this process is still not fully understood. There is increasing evidence that these cases of recurrent implantation failure might have an immunologic background. Uterine natural killer (NK) cells provide immune-modulation at the interface between maternal decidua and the trophoblast. The aim of this study to evaluate whether there was a significant difference in the number of endometrial CD56+ NK between women with a history of recurrent implantation failure and women who had a live birth. Materials and Methods: Patients with a history of recurrent implantation failure were included in the study. Twenty-five women with a history of recurrent implantation failure were assigned to the case group, and 25 women who had one or more live births were assigned to the control group. Endornetrial biopsies were obtained during the luteal phase on the 21st-24th clay of the menstrual cycle. Results: There was a statistically significant difference between the groups concerning the number of deliveries (p<0.001) and miscarriages (p<0.001). The mean number of uNK was 10.5 +/- 10.5 cells/mm(2) in the case group and 19.2 +/- 11.2 cells/mm(2) in the control group. There was a statistically significant difference between the two groups (p=0.003). Conclusion: Implantation failure is a multifactorial problem of reproductive medicine. The results of our study suggest that uterine NK play a role in the progress of normal pregnancy and reduced uterine NK cell numbers were associated with implantation failure.en_US
dc.identifier.doi10.4274/tjod.galenos.2020.90359
dc.identifier.endpage239en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue4en_US
dc.identifier.pmid33343968en_US
dc.identifier.scopus2-s2.0-85110049265en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage236en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2020.90359
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16468
dc.identifier.volume17en_US
dc.identifier.wosWOS:000598157300001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal Of Obstetrics And Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCd56en_US
dc.subjectImmunohistochemistryen_US
dc.subjectIn Vitro Fertilizationen_US
dc.subjectRecurrent Implantation Failureen_US
dc.subjectUterine Natural Killer Cellsen_US
dc.titleEndometrial CD56+natural killer cells in women with recurrent implantation failure: An immunohistochemical studyen_US
dc.typeArticleen_US

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