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Öğe Antidepressants and menstruation disorders in women: a cross-sectional study in three centers(Elsevier Science Inc, 2012) Uguz, Faruk; Sahingoz, Mine; Kose, Seyit Ali; Ozbebit, Ozgur; Sengul, Cem; Selvi, Yavuz; Sengul, Ceyhan BalciObjective: The relationship between menstruation disorders and antidepressant drugs usage in women remains unclear. In this study, we aimed to investigate the incidence rate of antidepressant-related menstruation disorders and to examine whether or not antidepressant use is associated with menstrual disorders in women. Methods: The study sample was gathered from three centers and four hospitals. A total of 1432 women who met the criteria of inclusion were included in the study. The sample was divided into two groups: the antidepressant group (n=793) and the control group (n=639). The menstruation disorders were established with reports from the study participants on the basis of related gynecological descriptions. Results: The prevalence of menstrual disorders was significantly higher in the antidepressant group (24.6%) than the control group (12.2%). The incidence of antidepressant-induced menstruation disorder was 14.5%. The antidepressants most associated with menstrual disorders were paroxetine, venlafaxine, sertraline and their combination with mirtazapine. Overall, the incidence rate was similar in women receiving selective serotonin reuptake inhibitors and serotonin noradrenaline reuptake inhibitors. Conclusions: The results of the present study suggest that menstruation disorders are frequently observed in women taking antidepressants and that it appears to be associated with antidepressant use at least in some women. (C) 2012 Elsevier Inc. All rights reserved.Öğe Approach to COVID-19 vaccine hesitancy based on some psychological symptoms and attachment theory: A web-based community survey(Kare Publ, 2023) Gica, Sakir; Sahingoz, Mine; Tanriverdi, Esra CinarObjective: The aim of this study is to investigate the effects of psychiatric symptoms such as anxiety, obsession, hostility, and attachment styles, which may be associated with COVID-19 vaccine hesitancy.Method: A total of 504 adult participants were included in the study. The sociodemographic data form, including questions on information about participants' COVID-19 infection history and concerns about COVID-19 vaccines, was filled out by the participants. The participants were evaluated with the anxiety, obsessive-compulsive disorder (OCD), hostility, and paranoid ideation subscales of the Symptom Checklist - Revised 90 scale and the Adults Attachment Style Scale (AASS). The participants were divided into three groups: vaccinated group (VG), nonvaccinated but intend to get vaccinated group (IGV), and nonvaccinated group and not intend to get vaccinated group (NIGV).Results: The mean score of the AASS secure subscale was higher (p=0.009), while the SCL-90 anxiety subscale was lower (p=0.003) in the NIGV group. The mean score of the SCL-90 OCD subscale in the NIGV group was lower than that in the IGV group (p=0.040). Regression analysis showed that concerns about the safety of vaccines (OR: 140, p<0.001) and having secure attachment style (OR: 1.787, p=0.019) increase the intention to not be vaccinated. However, it was found that high anxiety scores decreased the intention not to be vaccinated (OR: 0.966, p=0.035).Conclusion: The findings of the current study indicate that secure attachment style and clinical psychiatric entities such as anxiety and obsession were effective on vaccine hesitancy. However, this interaction needs to be interpreted carefully in the context of the perceived level of COVID-19 threat, more detailed information about the safety and necessity of vaccines, the relationship of individuals with their social environment, and the predominance of vaccine hesitancy in their social environment.Öğe Approach to COVID-19 vaccine hesitancy based on some psychological symptoms and attachment theory: A web-based community survey(Kare Publ, 2023) Gica, Sakir; Sahingoz, Mine; Tanriverdi, Esra CinarObjective: The aim of this study is to investigate the effects of psychiatric symptoms such as anxiety, obsession, hostility, and attachment styles, which may be associated with COVID-19 vaccine hesitancy.Method: A total of 504 adult participants were included in the study. The sociodemographic data form, including questions on information about participants' COVID-19 infection history and concerns about COVID-19 vaccines, was filled out by the participants. The participants were evaluated with the anxiety, obsessive-compulsive disorder (OCD), hostility, and paranoid ideation subscales of the Symptom Checklist - Revised 90 scale and the Adults Attachment Style Scale (AASS). The participants were divided into three groups: vaccinated group (VG), nonvaccinated but intend to get vaccinated group (IGV), and nonvaccinated group and not intend to get vaccinated group (NIGV).Results: The mean score of the AASS secure subscale was higher (p=0.009), while the SCL-90 anxiety subscale was lower (p=0.003) in the NIGV group. The mean score of the SCL-90 OCD subscale in the NIGV group was lower than that in the IGV group (p=0.040). Regression analysis showed that concerns about the safety of vaccines (OR: 140, p<0.001) and having secure attachment style (OR: 1.787, p=0.019) increase the intention to not be vaccinated. However, it was found that high anxiety scores decreased the intention not to be vaccinated (OR: 0.966, p=0.035).Conclusion: The findings of the current study indicate that secure attachment style and clinical psychiatric entities such as anxiety and obsession were effective on vaccine hesitancy. However, this interaction needs to be interpreted carefully in the context of the perceived level of COVID-19 threat, more detailed information about the safety and necessity of vaccines, the relationship of individuals with their social environment, and the predominance of vaccine hesitancy in their social environment.Öğe Aripiprazole in Depersonalization Disorder Comorbid With Major Depression and Obsessive-Compulsive Disorder: 3 Cases(Lippincott Williams & Wilkins, 2014) Uguz, Faruk; Sahingoz, MineDepersonalization is a frequent symptom in depression and obsessive-compulsive disorder (OCD), but sometimes, it may be severe and concurrently diagnosed as a disorder. The treatment of depersonalization disorder both alone and comorbid with other psychiatric disorders is as yet unclear. This report presents the successful treatment with aripiprazole of concurrent depersonalization disorder in 3 patients with depression or OCD. The psychiatric disorders were diagnosed through structured clinical interviews. Assessments were by means of Yale-Brown Obsessive-Compulsive Scale, the Clinical Global Impression-Improvement Scale, and the 17-item Hamilton Rating Scale for Depression. Aripiprazole may be a beneficial psychotropic drug in the treatment of depersonalization disorder comorbid with OCD or depression, which is an important problem in clinical practice.Öğe Axis I and Axis II diagnoses in women with PCOS(Elsevier Science Inc, 2013) Sahingoz, Mine; Uguz, Faruk; Gezginc, Kazim; Korucu, Dilay GokObjective: The objective was to determine the current prevalence of Axis I and Axis II psychiatric diagnoses in patients with polycystic ovary syndrome (PCOS). Method: The study sample included 73 patients with PCOS and 73 control subjects. Psychiatric disorders were determined by structured clinical interviews. Results: The rate of any Axis I psychiatric disorder (28.8% vs. 15.1%), social phobia (13.7% vs. 2.7%), generalized anxiety disorder (11.0% vs. 1.4%), any Axis II psychiatric disorder (23.3% vs. 9.6%) and avoidant personality disorder (12.3% vs. 1.4%) was significantly more common in the patient group compared to the control group. Of women with PCOS, 21 (28.8%) had at least one Axis I and 17 (23.3%) had at least one Axis II diagnosis. The most common Axis I disorder was social phobia (13.7%) and the most common Axis II disorder was avoidant personality disorder (12.3%) in women with PCOS. Social phobia, generalized anxiety disorder, and avoidant personality disorder were significantly more common in the patient group compared to the control group. Conclusion: Our results suggest that a considerable proportion of women with PCOS also present with anxiety and personality disorders. (C) 2013 Elsevier Inc. All rights reserved.Öğe Birth Weight and Preterm Birth in Babies of Pregnant Women With Major Depression in Relation to Treatment With Antidepressants(Lippincott Williams & Wilkins, 2014) Sahingoz, Mine; Yuksel, Goksen; Karsidag, Cagatay; Uguz, Faruk; Sonmez, Erdem Onder; Annagur, Bilge Burcak; Annagur, AliObjective It is unclear whether antidepressant treatment has a preventive effect on negative neonatal outcomes due to major depression in pregnant women. The objective of the present study was to compare women with major depression treated with antidepressants, untreated women with major depression, and healthy women during pregnancy with respect to birth weight and preterm birth. Methods The study sample included a total of 23 women taking antidepressant medication, 36 women who were not taking antidepressant medication for major depression during pregnancy, and 30 healthy women. Major depression was diagnosed via the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Results The study groups were similar with respect to sociodemographic characteristics. Compared with infants of healthy control subjects, infants of untreated major depressed women had significantly lower birth weight and shorter gestational age at delivery. There is no significant difference between infants of major depressed women treated with antidepressants and infants of healthy subjects for these variables. Conclusions Our results suggest that antidepressants may have beneficial effects on the risk of low birth weight and preterm birth in the infants of depressed women.Öğe COVID-19-Related Obsessions and Its Predictors: A Community-Based Research in Turkey(Marmara Univ, Inst Health Sciences, 2023) Tanriverdi, Esra Cinar; Cevheroglu, Busra Arslan; Ozkurt, Zulal; Sahingoz, MineObjective: This study aims to investigate the psychological effects of the COVID-19 pandemic on the Turkish society and identify COVID-19-related obsessions and predictive factors.Methods: This cross-sectional study was performed with 859 volunteer participants. Data were collected using an online questionnaire between 01 and 08 June 2020. A sociodemographic information form, Depression, Anxiety and Stress Scale-21 (DASS-21), Impact of Event Scale-Revised (IES-R), and Obsession with COVID-19 Scale (OSC), were used as data collection tools. Data were analysed using SPSS 20 statistical software.Results: The mean age of the participants was 40.41 +/- 13.69 (18-70), 55.3% were women, and %63.7 were married. Cleaning habits increased during the pandemic in 76% of the participants. The prevalence of depression, anxiety, and stress symptoms were 36.9%, 42.3%, and 18.2%, respectively. Depression was severe or very severe in 6.3% of the participants, anxiety in 15.4%, and stress in 4.3%. Post-traumatic stress disorder (PTSD) was determined in 11.3% of the participants, and COVID-19-related obsessions in 17.6%. Obsessions were greater in the variables of eating (r= 0.26, p<0.001), sleep (r= 0.20, p<0.20), cleaning (r= 0.17, p<0.001), television watching habits (r= 0.09, p< 0.05), and family relationships (r= 0.11, p< 0.01) during the pandemic. The most effective predictors among the COVID-19-related obsessions were depression (p<0.001) and anxiety (p<0.001), IES-R scores (p<0.001), and finally age (p< 0.05), gender (p<0.001), and education level (p<0.05).Conclusion: The COVID-19 pandemic has had severe psychological effects on society, especially in terms of obsessions. Awareness of these must be established, and measures aimed at improving societal mental health must be adopted.Öğe Ecchymosis Related to Paroxetine and Sertraline(Modestum Ltd, 2015) Sahingoz, Mine; Sonmez, Erdem OnderSelective serotonin reuptake inhibitors (SSRIs) are widely used for treating depressive and anxiety disorders. Although SSRIs have a safety profile, some authors have reported that they associated with an increased risk of bleeding events. We report a case of paroxetine- and sertraline-associated ecchymoses in a patient with depression.Öğe Ecchymosis Related to Paroxetine and Sertraline(Modestum Ltd, 2015) Sahingoz, Mine; Sonmez, Erdem OnderSelective serotonin reuptake inhibitors (SSRIs) are widely used for treating depressive and anxiety disorders. Although SSRIs have a safety profile, some authors have reported that they associated with an increased risk of bleeding events. We report a case of paroxetine- and sertraline-associated ecchymoses in a patient with depression.Öğe Effect of Maternal Depression on Brain-derived Neurotrophic Factor Levels in Fetal Cord Blood(Korean Coll Neuropsychopharmacology, 2019) Sonmez, Erdem Onder; Uguz, Faruk; Sahingoz, Mine; Sonmez, Gulsum; Kaya, Nazmiye; Camkurt, Mehmet Akif; Gokmen, ZeynelObjective: We aimed to assess the association between cord blood brain-derived neurotrophic factor (BDNF) concentration and maternal depression during pregnancy. Methods: A total of 48 pregnant women, admitted for elective caesarean section to Department of Obstetrics and Gynecology, The Konya Research and Training Hospital and Konya Necmettin Erbakan University Meram Medical Faculty, were included in this study. The study group included 23 women diagnosed as having depression during pregnancy and the control group included 25 pregnant women who did not experience depression during pregnancy. Results: The groups had similar sociodemographic characteristics. Cord blood BDNF concentration was significantly lower in babies born to mothers with major depression as compared with those in the control group. We didn't find any correlation between the umbilical cord blood BDNF levels and BDI scores. Conclusion: The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.Öğe The effects of maternal major depression, generalized anxiety disorder, and panic disorder on birth weight and gestational age: A comparative study(Pergamon-Elsevier Science Ltd, 2013) Uguz, Faruk; Sahingoz, Mine; Sonmez, Erdem Onder; Karsidag, Cagatay; Yuksel, Goksen; Annagur, Bilge Burcak; Annagur, AliObjective: The present study comparatively examined the impact of maternal major depression, generalized anxiety disorder and panic disorder on gestational age and birth weight. Methods: A total of 90 women (24 subjects with major depression, 19 subjects with panic disorder, 22 subjects with generalized anxiety disorder, and 25 healthy subjects) in the perinatal period who were admitted to three hospitals were included in the study. Psychiatric diagnoses were determined by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The birth weight and gestational age of the subjects in each groups were compared with one-way analysis of variance (ANOVA). Results: There were significant differences among the study groups for birth weight and gestational age (P < 0.001 for both variables). These parameters were significantly lower in the subjects with major depression (P = 0.021 and P = 0.015, respectively) and panic disorder (P < 0.001 for both variables) compared to healthy controls. Compared with major depression, panic disorder was associated more negatively with birth weight (P = 0.036). Conclusion: Major depression, and especially panic disorder, may negatively affect the gestational length and birth weight. (C) 2013 Elsevier Inc. All rights reserved.Öğe Is Depression Associated With Glucose Tolerance Abnormality in Pregnant Women? A Cross-Sectonal Study(W B Saunders Co-Elsevier Inc, 2013) Gezginc, Kazim; Sahingoz, Mine; Uguz, Faruk; Yazici, FatmaThis study aims to examine the association between glucose tolerance abnormality and depression and anxiety in pregnant women. One hundred and sixty-seven women with gestational ages ranging from 24 to 28 weeks were screened with the 50 g oral glucose challenge test. All participants were assessed with the Beck Depression Inventory and the Beck Anxiety Inventory. The rate of depression was higher in women with abnormal glucose results (44.3%) than in women with normal glucose results (21.7%). Similarly, depressed women had higher glucose levels than non-depressed women. Findings suggest that depression and anxiety may be associated with glucose tolerance abnormality in pregnant women. (C) 2013 Elsevier Inc. All rights reserved.Öğe Low-Dose Imipramine for Treatment of Panic Disorder During Pregnancy A Retrospective Chart Review(Lippincott Williams & Wilkins, 2014) Uguz, Faruk; Sahingoz, Mine; Gungor, Buket; Askin, RustemAlthough imipramine is one of the antidepressants that could be effective in the treatment of panic disorder, data on its usage for this diagnosis in the pregnancy period are limited. This report presents the results of 16 pregnant women with panic disorder without comorbid diagnosis who underwent low-dose imipramine (10-40 mg/d) treatment. According to the Clinical Global Impression-Improvement Scale, 12 (75%) of 16 women responded to the treatment. The results suggest that low-dose imipramine may be useful for the treatment of panic disorder during pregnancy.Öğe Maternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levels(Pergamon-Elsevier Science Ltd, 2013) Uguz, Faruk; Sonmez, Erdem Onder; Sahingoz, Mine; Gokmen, Zeynel; Basaran, Mustafa; Gezginc, Kazim; Sonmez, GulsumObjectives: The study aimed to investigate whether maternal GAD during pregnancy affects fetal circulating brain-derived neurotrophic factor (BDNF), which plays important roles in neuronal development, by comparing cord blood BDNF levels in newborn infants of women with and without GAD. Methods: Study sample included 19 women with GAD and 25 women without any psychiatric disorder. GAD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of BDNF level was obtained from the umbilical cord during delivery. Results: Cord blood BDNF levels in newborn infants of healthy women were approximately two-fold compared to newborn infants of women with GAD, and the difference was statistically significant. The duration of GAD during pregnancy was the only variable correlating with cord blood BDNF levels. Conclusions: The study results imply that prolonged maternal GAD during pregnancy may negatively influence neurodevelopment of the fetus through lower levels of circulating BDNF. (C) 2013 Elsevier Inc. All rights reserved.Öğe Neuroinflammation in the fetus exposed to maternal obsessive-compulsive disorder during pregnancy: A comparative study on cord blood tumor necrosis factor-alpha levels(W B Saunders Co-Elsevier Inc, 2014) Uguz, Faruk; Sonmez, Erdem Onder; Sahingoz, Mine; Gokmen, Zeynel; Basaran, Mustafa; Gezginc, Kazim; Sonmez, GulsumObjective: The relationship between maternal psychiatric disorders and fetal neurodevelopment is unclear. Obsessive-compulsive disorder (OCD) is relatively frequent during pregnancy. The study aimed to investigate whether maternal OCD during pregnancy affects fetal circulating tumor necrosis factor-alpha (TNF-alpha) levels, an important pro-inflammatory cytokine, by comparing cord blood TNF-alpha levels in newborn infants of women with and without OCD. Methods: The study sample included 7 women with OCD and 30 healthy women. OCD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of TNF-alpha level was obtained from the umbilical cord during delivery. Results: Cord blood TNF-alpha levels in newborn infants exposed to maternal OCD were significantly higher compared to non-exposed infants. Maternal anxiety symptom level was found to positively correlate with cord blood TNF-alpha levels in newborn infants of women with OCD. Conclusion: The study results imply that maternal OCD during pregnancy may lead to neuroinflammation in the developing fetal brain through higher levels of circulating TNF-alpha. (C) 2014 Elsevier Inc. All rights reserved.Öğe Persistent cerebellar syndrome due to lithium treatment: a case report(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2013) Sahingoz, Mine; Dagistanli, Adnan AlperWe report the case of a 23-year-old man with bipolar disorder who developed permanent cerebellar damage of lithium intake within therapeutic ranges. Cerebellar symptoms such as dysarthria, ataxia, and tremor developed 1 year after the beginning of lithium. Two years later, cerebellar signs and symptoms were found to be permanent in the patient. Cerebellar syndrome was most probably due to lithium neurotoxicity, which was associated with the administration of antipsychotic.Öğe Weight gain and associated factors in patients using newer antidepressant drugs(Elsevier Science Inc, 2015) Uguz, Faruk; Sahingoz, Mine; Gungor, Buket; Aksoy, Fadime; Askin, RustemObjective: The aim of the present study was to examine weight gain and its association with clinical and sociodemographic characteristics in patients using newer antidepressants. Methods: The study had a cross-sectional design. A total of 362 consecutive psychiatric patients taking antidepressant drugs for 6 to 36 months were included in the study. Results: The prevalence rate of weight gain was 55.2%; 40.6% of the patients had a weight gain of 7% or more compared to the baseline. Overall, antidepressant use was significantly related to increased body weight. Specifically, citalopram, escitalopram, sertraline, paroxetine, venlafaxine, duloxetine and mirtazapine, but not fluoxetine, were associated with significant weight gain. Multivariate logistic regression analysis indicated that lower education status, lower body mass index at the onset of antidepressant use and family history of obesity were independent predictors of weight gain >= 7% compared to the baseline. Conclusions: The study results suggest that patients who take newer antidepressants might have significant problems related to body weight. (C) 2015 Elsevier Inc. All rights reserved.
