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    Determining Stable Structure and in Vitro Antiproliferative Properties of a Novel 3-(2-((4-Trifluoromethyl)phenyl)amino)thiazol-4-yl)-2H-chromen-2-one Molecule
    (Wiley-V C H Verlag Gmbh, 2023) Sariguney, Ahmet Burak; Sarikaya, Ebru Karakas; Pehlivanoglu, Suray
    Since coumarin and thiazole derivatives are known to have antioxidant properties, a novel derivative was synthesized in this article. 3-(2-((4-(trifluoromethyl)phenyl)amino)thiazol-4-yl)-2H-chromen-2-one (ATC) was synthesized as a novel compound with high yield and characterized by Raman, FT-IR, C-13-NMR, and H-1-NMR spectroscopic procedures and DFT calculations. In this study, the potential in vitro antiproliferative properties of the ATC compound were evaluated on colorectal cancer (HT29) and melanoma (SK-MEL-30) cell lines. According to the results, the compound was found to be significantly active, approximately 2.6-fold, against melanoma cells compared to healthy fibroblast (L929) cells. Unlike melanoma cells, the compound did not have any adverse effects on colorectal cancer cells. Due to these findings, the compound can be harnessed as a promising antiproliferative drug candidate for preclinical studies against melanoma.
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    A newly synthesized thiazole derivative as a fluoride ion chemosensor: Naked-eye, spectroscopic, electrochemical and NMR studies
    (Pergamon-Elsevier Science Ltd, 2014) Sariguney, Ahmet Burak; Saf, Ahmet Ozgur; Coskun, Ahmet
    2,3-Indoledione 3-thiosemicarbazone (TSCI) and a novel compound 3-(2-(4-(4-phenoxyphenyl)thiazol-2-yl)hydrazono)indolin-2-one (FTHI) were synthesized with high yield and characterized by spectroscopic techniques. The complexation behaviors of TSCI and FTHI for various anionic species (F-, Cl-, Br-, l(-), NO2-, NO3-, BzO(-), HSO4-, ClO4-) in CH3CN were investigated and compared by UV-vis spectroscopy, cyclic voltammetry and H-1 NMR titration techniques. FTHI showed high degree of selectivity for fluoride over other anions. This selectivity could be easily observed by the naked eye, indicating that FTHI is potential colorimetric sensor for fluoride anion. (C) 2014 Elsevier B.V. All rights reserved.
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    Synthesis and Antimicrobial Activity of Some 2-aminothiazole and 2-aminothiadiazine Derivatives
    (Wiley, 2018) Sariguney, Ahmet Burak; Kocabas, Erdal; Erci, Fatih; Torlak, Emrah; Coskun, Ahmet
    In this study, some thiazole and thiadiazine ring bearing compounds were synthesized, characterized by spectroscopic techniques, and evaluated as potential antimicrobial agents. Their antimicrobial activities evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. From these compounds, Compounds 2, 5, and 9 have been found to selectively inhibit Gram positives.
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    Synthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives
    (Biointerface Research Applied Chemistry, 2021) Kocabas, Erdal; Sariguney, Ahmet Burak; Erci, Fatih; Cakir-Koc, Rabia; Kocabas, Hilal Ozen; Torlak, Emrah; Coskun, Ahmet
    In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and H-1 NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.