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Öğe Assessment of Corneal Sensation, Innervation and Retinal Nerve Fiber Layer in Patients Treated with Multiple Intravitreal Ranibizumab Injections(Public Library Science, 2017) Bitirgen, Gulfidan; Belviranli, Selman; Malik, Rayaz A.; Kerimoglu, Hurkan; Satirtav, Gunhal; Zengin, NazmiPurpose To evaluate the effects of repeated intravitreal ranibizumab injections on corneal sensitivity, corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with neovascular age-related macular degeneration (AMD). Methods Sixty-six eyes of 33 patients who had received unilateral repeated intravitreal ranibizumab injections (0.5 mg/0.05 ml) for the treatment of AMD and 25 eyes of 25 healthy subjects were included in the study. Central corneal sensation was measured using the contact Cochet-Bonnet esthesiometer. The laser scanning in vivo corneal confocal microscope was used to determine corneal SBNP parameters. The peripapillary RNFL thickness was assessed with spectral-domain optical coherence tomography. Data obtained from the ranibizumab-injected eyes were compared with those of the fellow non-treated eyes and the eyes of the healthy control subjects. Results The mean number of ranibizumab injections per eye was 8.9 +/- 5.0 (range 3-20). There were no statistically significant differences in the central corneal sensitivity threshold and corneal SBNP parameters between the ranibizumab-injected eyes and the fellow untreated eyes or between those with neovascular AMD and the healthy control group (P>0.05 for all). The average peripapillary RNFL thickness of the treated eyes did not differ significantly to the fellow eyes (P=0.237), and the eyes of healthy control subjects (P=0.918). There were no significant correlations between the number of ranibizumab injections and any of the study parameters. Conclusions Multiple intravitreal injections of ranibizumab seem to have no harmful effects on corneal sensitivity, innervation and peripapillary RNFL thickness in patients with AMD.Öğe Assessment of Corneal Sensation, Innervation and Retinal Nerve Fiber Layer in Patients Treated with Multiple Intravitreal Ranibizumab Injections(Public Library Science, 2017) Bitirgen, Gulfidan; Belviranli, Selman; Malik, Rayaz A.; Kerimoglu, Hurkan; Satirtav, Gunhal; Zengin, NazmiPurpose To evaluate the effects of repeated intravitreal ranibizumab injections on corneal sensitivity, corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with neovascular age-related macular degeneration (AMD). Methods Sixty-six eyes of 33 patients who had received unilateral repeated intravitreal ranibizumab injections (0.5 mg/0.05 ml) for the treatment of AMD and 25 eyes of 25 healthy subjects were included in the study. Central corneal sensation was measured using the contact Cochet-Bonnet esthesiometer. The laser scanning in vivo corneal confocal microscope was used to determine corneal SBNP parameters. The peripapillary RNFL thickness was assessed with spectral-domain optical coherence tomography. Data obtained from the ranibizumab-injected eyes were compared with those of the fellow non-treated eyes and the eyes of the healthy control subjects. Results The mean number of ranibizumab injections per eye was 8.9 +/- 5.0 (range 3-20). There were no statistically significant differences in the central corneal sensitivity threshold and corneal SBNP parameters between the ranibizumab-injected eyes and the fellow untreated eyes or between those with neovascular AMD and the healthy control group (P>0.05 for all). The average peripapillary RNFL thickness of the treated eyes did not differ significantly to the fellow eyes (P=0.237), and the eyes of healthy control subjects (P=0.918). There were no significant correlations between the number of ranibizumab injections and any of the study parameters. Conclusions Multiple intravitreal injections of ranibizumab seem to have no harmful effects on corneal sensitivity, innervation and peripapillary RNFL thickness in patients with AMD.Öğe Assessment of Monocyte/HDL Ratio in Branch Retinal Vein Occlusion(Taylor & Francis Inc, 2020) Satirtav, Gunhal; Mirza, Enver; Oltulu, Refik; Mirza, Gunsu Deniz; Kerimoglu, HurkanPurpose: The purpose of this article was to evaluate monocyte count and high-density lipoprotein (HDL) cholesterol levels and their ratio (monocyte/HDL ratio [MHR]) in patients with branch retinal vein occlusion (BRVO). Materials and Methods: A total of 50 participants were included in the study. Participants were divided into two groups: Twenty-five patients diagnosed with BRVO and 25 participants as the control group. Ocular examination findings and hematologic parameters were accessed from the file records and database, retrospectively. Results: The mean MHR was significantly higher in BRVO group compared to the control group (13.4 +/- 5.2 vs. 8.1 +/- 2.2, p < 0.001). In receiver operating characteristics analysis, the area under the curve for MHR was 0.862, and an MHR of >9.5 predicted BRVO with a sensitivity of 76% and specificity of 70.8%. Conclusion: The present study showed that elevated MHR is significantly associated with BRVO. Therefore, MHR may be a useful marker for the emergence of BRVO.Öğe Assessment of Ocular Surface in Patients With Ankylosing Spondylitis(Lippincott Williams & Wilkins, 2020) Oltulu, Refik; Turk, Huseyin Bugra; Oltulu, Pembe; Turk, Nazli; Satirtav, Gunhal; Gunduz, Mehmet KemalPurpose: To evaluate the clinical findings and ocular surface changes in patients with ankylosing spondylitis (AS). Methods: This prospective study involved 45 patients with AS (group 1) and 28 healthy subjects (group 2). Patients in group 1 were in the inactive period. The study subjects underwent a complete ophthalmic examination. The right eyes of the subjects in each group were tested for the study including slit-lamp examination, Schirmer I test, tear break-up time (TBUT), conjunctival impression cytology (CIC), and ocular surface disease index (OSDI). Results between the two groups were compared. Results: The mean Schirmer I test result was found as 12.2 +/- 8 mm in group 1 and 20.3 +/- 9.9 mm in group 2 (P<0.001), whereas the mean TBUT value was found as 3.8 +/- 1.9 sec in group 1 and 10.1 +/- 4.8 sec in group 2 (P<0.001). The OSDI scores were significantly higher in group 1 (36.5 +/- 19.4) than in group 2 (9.1 +/- 12.9, P<0.001). The CIC scores were significantly higher in group 1 (2.12 +/- 0.7) than in group 2 (0.57 +/- 0.6, P<0.001). Notably, none of the patients in group 1 showed grade 0 differentiation, and none of the patients in group 2 showed grade 2 or 3 differentiation. The CIC scores were significantly higher in group 1 (2.12 +/- 0.7) than in group 2 (0.57 +/- 0.6, P<0.001). Conclusion: Ocular surface changes, including squamous metaplasia in the bulbar conjunctiva, can be observed in patients with AS.Öğe Assessment of pupillary light reflex using dynamic pupillometry in laser-treated eyes with retinal vein occlusion(Sage Publications Ltd, 2021) Turk, Huseyin Bugra; Bitirgen, Gulfidan; Satirtav, Gunhal; Kerimoglu, HurkanPurpose: This study aims to evaluate the pupillary light reflex measured with dynamic pupillometry in patients who underwent retinal laser photocoagulation due to unilateral retinal vein occlusion (RVO). Methods: A total of 48 patients with unilateral RVO were included in the study. Thirty-four patients had undergone retinal laser photocoagulation while the remaining 14 patients that did not undergo laser treatment were observed for control purposes. Of the laser-treated eyes, 14 eyes (41.2%) had central RVO (CRVO) and 20 eyes (58.8%) had branch RVO (BRVO). Among the 14 patients with RVO without laser treatment, nine eyes (64.3%) had CRVO and five eyes (35.7%) had BRVO. Pupillary light reflexes were assessed with dynamic pupillometry (MonPackOne (R); Metrovision, France). The parameters of the eyes with RVO were compared with that of fellow healthy eyes. Results: Mean patient age was 65.8 +/- 10.4 years and median time after photocoagulation was 25.5 months. Eyes that received laser photocoagulation had lower pupil contraction amplitude (p = 0.037), prolonged contraction latency (p = 0.027), slower contraction velocity (p = 0.043), and slower dilation velocity (p < 0.001) compared to healthy fellow eyes. Subgroup analysis revealed that eyes with CRVO had lower contraction amplitude (p = 0.013) and slower dilation velocity (p = 0.003), and eyes with BRVO had slower dilation velocity (p = 0.003). Non-laser-treated eyes with RVO revealed no significant difference in any of the pupillary light reflex parameters compared to fellow eyes. Conclusion: Laser-treated eyes with RVO demonstrated changes in pupillary light reflex parameters including reduced contraction amplitude, prolonged contraction latency, and slower contraction and dilation velocities measured with dynamic pupillometry.Öğe Characteristics of the cornea in patients with pseudoexfoliation syndrome(Consel Brasil Oftalmologia, 2015) Oltulu, Refik; Satirtav, Gunhal; Kayitmazbatir, Emine Tinkir; Bitirgen, Gulfidan; Ozkagnici, Ahmet; Karaibrahimoglu, AdnanPurpose: To quantify the morphological alterations in corneal nerve fibers and cells in patients with pseudoexfoliation syndrome (PEX) and their relationship with the presence of hyperreflective endothelial deposits observed using in vivo confocal microscopy. Methods: One eye each of 37 patients with PEX and 20 age-matched healthy control subjects was evaluated by in vivo corneal confocal microscopy. Patients with PEX were further classified into two groups: those with and without hyperreflective endothelial deposits. We evaluated the densities of basal epithelial cells, anterior and posterior stromal keratocytes, and endothelial cells and structure of sub-basal nerve fibers. Results: The mean anterior and posterior stromal keratocyte and endothelial cell densities and corneal sub-basal nerve plexus variables were significantly lower in patients with PEX compared with those in healthy control subjects. The mean basal epithelial cell density did not significantly differ. Conclusion: Eyes with PEX presented decreased corneal sub-basal nerve plexus variables and cell densities in all corneas, except for the mean basal epithelial cell density. Further, a trend of lower corneal sub-basal nerve plexus measurements in patients with hyperreflective endothelial deposits compared with those without endothelial deposits was observed.Öğe Conjunctival Impression Cytology and Dry Eye in Patients With Ulcerative Colitis: A Pilot Study(Lippincott Williams & Wilkins, 2018) Oltulu, Pembe; Oltulu, Refik; Asil, Mehmet; Satirtav, Gunhal; Mirza, EnverPurpose: The aim of this study was to compare signs of dry eye between ulcerative colitis (UC) patients and healthy subjects. Methods: Fifteen patients with UC (group 1) and 15 healthy subjects (group 2) were enrolled in this study. Tear volume measurement, Schirmer-I test with no anesthetic, tear break-up time, and conjunctival impression cytology (CIC) were evaluated in both groups. Results: Patients with UC showed lower tear volumes when compared with healthy subjects (P<0.05). There was a statistically significant difference in distribution of CIC grades between groups 1 and 2 (P<0.05). Tear break-up time and Schirmer-I measurements were significantly lower in group 1 compared with group 2 (P<0.05). Conclusions: The results of this study indicate that UC is associated with demonstrable disturbances in tear function and conjunctival cytology.Öğe Corneal nerve loss and increased Langerhans cells are associated with disease severity in patients with rheumatoid arthritis(Springernature, 2023) Bitirgen, Gulfidan; Kucuk, Adem; Ergun, Mustafa Cagri; Satirtav, Gunhal; Malik, Rayaz A.Background/ObjectivesRheumatoid arthritis (RA) is a multisystem autoimmune disorder characterized by articular and extra-articular manifestations. Neuropathy is a poorly studied manifestation of RA. The aim of this study was to utilize the rapid non-invasive ophthalmic imaging technique of corneal confocal microscopy to identify whether there is evidence of small nerve fibre injury and immune cell activation in patients with RA.Subjects/MethodsFifty consecutive patients with RA and 35 healthy control participants were enrolled in this single-centre, cross-sectional study conducted at a university hospital. Disease activity was assessed with the 28-Joint Disease Activity Score and erythrocyte sedimentation rate (DAS28-ESR). Central corneal sensitivity was measured with a Cochet-Bonnet contact corneal esthesiometer. A laser scanning in vivo corneal confocal microscope was used to quantify corneal nerve fibre density (CNFD), nerve branch density (CNBD), nerve fibre length (CNFL), and Langerhans cell (LC) density.ResultsCorneal sensitivity (P = 0.01), CNFD (P = 0.02), CNBD (P < 0.001), and CNFL (P < 0.001) were lower, and mature (P = 0.001) and immature LC densities (P = 0.011) were higher in patients with RA compared to control subjects. CNFD (P = 0.016) and CNFL (P = 0.028) were significantly lower in patients with moderate to high (DAS28-ESR > 3.2) compared to mild (DAS28-ESR <= 3.2) disease activity. Furthermore, the DAS28-ESR score correlated with CNFD (r = -0.425; P = 0.002), CNBD (rho = -0.362; P = 0.010), CNFL (r = -0.464; P = 0.001), total LC density (rho = 0.362; P = 0.010) and immature LC density (rho = 0.343; P = 0.015).ConclusionsThis study demonstrates reduced corneal sensitivity, corneal nerve fibre loss and increased LCs which were associated with the severity of disease activity in patients with RA.Öğe Corneal Thickness During Corneal Collagen Cross-Linking with Isotonic Riboflavin Solution without Dextran(Turkish Ophthalmological Soc, 2014) Oltulu, Refik; Donbaloglu, Meryem; Satirtav, Gunhal; Zengin, Nazmi; Ozkagnici, AhmetObjectives: To monitor the corneal thickness change during the dextran-free isotonic riboflavin solution-aided corneal collagen cross-linking procedure in keratoconus patients. Materials and Methods: Corneal thickness measurements during the corneal collagen cross-linking (CXL) treatment for progressive keratoconus were evaluated. The corneal thickness measurements were obtained with ultrasonic pachymetry device at five different time points: 0, 15, and 30 minutes after epithelial removal and 15 and 30 minutes after the initiation of UVA irradiation. Results: Twenty-four eyes of 24 patients with progressive keratoconus were included in the study. The thinnest pachymetric values obtained at the 0, 15, and 30 minute measurements after corneal deepithelisation were 409.38 +/- 10.43 mu m (383-435 mu m), 434.56 +/- 17.68 mu m (400-485 mu m), and 457.44 +/- 21.78 mu m (428-516 mu m), respectively. Pachymetric values obtained at 15 and 30 minutes after UVA application to the cornea were 471.69 +/- 23.38 mu m (439-526 mu m) and 482.63 +/- 23.69 mu m (436-524 mu m), respectively. The gradual increase was found to be statistically significant when each measurement was compared with the previous values (p < 0.001). Conclusion: We found that the corneal thickness was not decreased during the CXL with dextran-free isotonic riboflavin solution; on the contrary, corneal thickness was increased regularly during the procedure.Öğe The Effect of Dehydration and Fasting on Corneal Biomechanical Properties and Intraocular Pressure(Lippincott Williams & Wilkins, 2016) Oltulu, Refik; Satirtav, Gunhal; Ersan, Ismail; Soylu, Erkan; Okka, Mehmet; Zengin, NazmiPurpose: To evaluate the changes in corneal biomechanical properties and intraocular pressure (IOP) during fasting period in healthy subjects. Methods: Seventy-two eyes of 72 fasting subjects (study group), and 62 eyes of 62 nonfasting subjects (control group) were enrolled in this prospective study undertaken at a single university hospital. All subjects underwent complete ophthalmologic examination including ocular biomechanical evaluation with ocular response analyzer. Ocular response analyzer measurement was performed on the right eyes of the subjects between 5.00 and 6.00 PM after approximately 14 hr of fasting for the study group and after a nonfasting period for the control group. The corneal hysteresis, corneal resistance factor, mean corneal compensated IOP (IOPcc), and Goldmann-correlated IOP (IOPg) values were measured with a patented dynamic bidirectional applanation process. Results: Goldmann-correlated IOP and IOPcc measurements in the study group and the control group were found as 13.8 +/- 2.8 mm Hg, 14.6 +/- 2.6 mm Hg and 16.3 +/- 2.2 mm Hg, 15.7 +/- 2.4 mm Hg, respectively. There was statistically significant difference within the two groups in IOPg and IOPcc (P < 0.001). In addition, corneal hysteresis and corneal resistance factor significantly decreased in study group compared with control group (P < 0.001, P = 0.012, respectively). Conclusion: Prolonged fasting causes a significant decrease in IOPg, IOPcc, corneal hysteresis, and corneal resistance factor in healthy subjects, altering the biomechanical properties of the cornea.Öğe Effect of Eye Rubbing on Corneal Biomechanical Properties and Intraocular Pressure(Turkish Ophthalmological Soc, 2014) Oltulu, Refik; Donbaloglu, Meryem; Satirtav, Gunhal; Okka, Mehmet; Ozkagnici, AhmetObjectives: To determine whether corneal biomechanical properties and intraocular pressure (IOP) are affected by eye rubbing. Materials and Methods: Healthy individuals, aged between 15 and 50 years, without any ocular pathological signs were included. Corneal biomechanical parameters, Goldmann-equivalent intraocular pressure (IOPg), corneal-compensated intraocular pressure (IOPcc), corneal resistance factor (CRF), and corneal hysteresis (CH) values were measured using an ocular response analyzer (ORA). Measurements were taken at baseline and immediately after 30 seconds of eye rubbing. ORA parameters before and after eye rubbing were analyzed using student's t test. A p-value less than 0.05 was considered statistically significant. Results: We included eighty-one eyes of 53 individuals with a mean age of 32 +/- 10.11(15-50) years. Before eye rubbing, the mean measurement values were as follows: CH 10.93 +/- 1.69 mmHg, CRF 10.82 +/- 1.78 mmHg, IOPg 15.76 +/- 3.18 mmHg, and IOPcc 15.74 +/- 2.69 mmHg. The mean values after eye rubbing were: CH 11.11 +/- 1.52 mmHg, CRF 10.54 +/- 1.56 mmHg, IOPg 14.32 +/- 3.10 mmHg, and IOPcc 14.20 +/- 2.77 mmHg. The decrease in CRF, IOPg, and IOPcc was statistically significant, while the change in CH was found to be statistically insignificant. Conclusion: CRF, IOPg, and IOPcc decreased significantly after eye rubbing and this should be considered before taking any ORA measurements and interpreting the results.Öğe Effect of mydriasis induced by topical 0.5% tropicamide instillation on the corneal biomechanical properties in healthy individuals measured by ocular response analyzer(Taylor & Francis Ltd, 2015) Oltulu, Refik; Satirtav, Gunhal; Altunkaya, Orhan; Bitirgen, Gulfidan; Okka, MehmetPurpose: This observational study aims to investigate the effects of tropicamide (0.5%) on corneal biomechanical properties, with the ocular response analyzer (ORA), in healthy individuals. Methods: Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) measurements of 38 (21 female and 17 male) healthy individuals, before and after 30 min of 0.5% tropicamide instillation, were performed by using the ORA. Results: The mean CH, CRF, IOPg and IOPcc measurements of the eyes were 10.2 +/- 1.9 mmHg, 10.3 +/- 2.1 mmHg, 15.7 +/- 3.4 mmHg, 16.4 +/- 3.3 mmHg pre-tropicamide, and 10.4 +/- 1.7 mmHg, 10.3 +/- 2.1 mmHg, 15.3 +/- 3.4 mmHg, 15.8 +/- 2.7 mmHg post-tropicamide, respectively. The differences between the pre- and post-tropicamide measurements of the eyes were insignificant (p = 0.184, p = 0.659, p = 0.294, p = 0.150, respectively; paired t-test). Conclusions: A tropicamide instillation does not lead to significant changes in the corneal biomechanical properties. Therefore, it can be used safely in disease, i.e. in the diagnosis and follow-up ORA as it does not cause any change.Öğe Evaluation of Choroidal Thickness in Age Related Macular Degeneration Using EDI OCT(Karger, 2014) Belviranli, Selman; Zengin, Nazmi; Satirtav, Gunhal; Dogru, Ismail[Abstract Not Availabe]Öğe In Vivo confocal Microscopic evaluation of corneal nerve Fibers and Dendritic cells in Patients With Behcet's Disease(Frontiers Media Sa, 2018) Bitirgen, Gulfidan; Kayitmazbatir, Emine Tinkir; Satirtav, Gunhal; Malik, Rayaz A.; Ozkagnici, AhmetCentral and peripheral nervous system involvement may occur during the course of Behcet's disease (BD). In vivo corneal confocal microscopy (CCM) can detect corneal small fiber damage and immune cell density. The aim of this study was to assess central corneal sensitivity, corneal subepithelial nerve plexus morphology and dendritic cell (DC) density in patients with BD. Forty-nine consecutive patients with BD and 30 healthy control subjects were included in this cross-sectional study conducted at a tertiary referral university hospital. Central corneal sensitivity was measured using the contact corneal esthesiometer (Cochet-Bonnet; Luneau, France). The laser scanning CCM (Heidelberg, Germany) was used to quantify corneal nerve fiber density (NFD), nerve branch density (NBD), nerve fiber length (NFL), and DC density. There was a significant reduction in NFD (P = 0.001) and NFL (P = 0.031) and an increase in DC density (P = 0.038) in patients with BD compared to healthy controls, whereas corneal sensitivity (P = 0.066) and NBD (P = 0.067) did not differ significantly. There was no difference in corneal sensitivity, corneal nerve parameters, or DC density between BD patients with [n = 18 (36.7%)] and without a previous history of uveitis (P > 0.05 for all). Disease duration [median (IQR), 6.5 (4.0-14.5) years] correlated with corneal sensitivity (rho = -0.463; P = 0.001) and NFD (rho = -0.304; P = 0.034) and corneal sensitivity correlated with NFD (rho = 0.411; P = 0.003) and NFL (rho = 0.295; P = 0.039) in patients with BD. CCM demonstrates corneal sub-basal nerve fiber loss and increased DC density, providing a non-invasive ophthalmic means to identify peripheral neuropathy and inflammation in patients with BD.Öğe Influence of Cyclopentolate Hydrochloride on Corneal Biomechanical Properties in Healthy Individuals(Lippincott Williams & Wilkins, 2014) Oltulu, Refik; Satirtav, Gunhal; Kerimoglu, Hurkan; Zengin, Nazmi; Ozkagnici, Ahmet; Okka, MehmetObjective: This observational study aims to investigate the effects of cyclopentolate hydrochloride (1%) on corneal biomechanical properties, with the ocular response analyzer (ORA), in healthy individuals. Methods: Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) measurements of 36 (15 female and 21 male) healthy individuals, before and after 45 min of 1% cyclopentolate hydrochloride instillation, were performed by the ORA. Results: The mean CH and IOPcc measurements of the eyes were 10.63 +/- 1.17 mm Hg and 15.15 +/- 2.69 mm Hg, precycloplegia, and 11.09 +/- 1.32 mm Hg and 14.16 +/- 2.77 mm Hg, postcycloplegia, respectively. The differences between the precycloplegia and postcycloplegia in both measurements were statistically significant (P=0.031, P=0.016, respectively; paired t test). The mean CRF and mean IOPg measurements of the eyes were 10.40 +/- 1.16 mm Hg and 14.83 +/- 2.56 mm Hg, precycloplegia, and 10.61 +/- 1.33 mm Hg and 14.25 +/- 2.65 mm Hg, postcycloplegia, respectively. The differences between the precycloplegia and postcycloplegia measurements of the eyes were insignificant (P=0.264 and P=0.100, respectively; paired t test). Conclusions: A 1% cyclopentolate hydrochloride instillation leads to significant changes in the CH values and IOPcc measurements. This should be taken into account during the evaluation of refractive surgery candidates and in clinical conditions where ORA measurements are considered in the diagnosis and follow-up.Öğe Intraocular lens explantation or exchange: indications, postoperative interventions, and outcomes(Consel Brasil Oftalmologia, 2015) Oltulu, Refik; Ersan, Ismail; Satirtav, Gunhal; Donbaloglu, Meryem; Kerimoglu, Hurkan; Ozkagnici, AhmetPurpose: To analyze the indications for explantation or exchange of intraocular lenses (IOLs), which were originally implanted for the correction of aphakia during cataract extraction. Methods: All cases that involved intraocular lens explantation or exchange in one institution between January 2008 and December 2014 were analyzed retrospectively. Results: In total, 93 eyes of 93 patients were analyzed. The median time interval between implantation and explantation of the anterior chamber intraocular lenses (AC IOL) and posterior chamber intraocular lenses (PC IOL) was 83.40 +/- 83.14 months (range: 1-276 months) and 55.14 +/- 39.25 months (range: 1-168 months), respectively. Pseudophakic bullous keratopathy (17 eyes, 38.6%) and persistent iritis (12 eyes, 27.8%) in the AC IOL group and dislocation or decentration (30 eyes, 61.2%) and incorrect IOL power (nine eyes, 18.4%) in the PC IOL group were the most common indications for explantation of IOLs. The mean logMAR best corrected visual acuity (BCVA) improved significantly from 1.30 preoperatively to 0.62 postoperatively in the PC IOL group (p<0.001) but did not improve significantly in the AC IOL group (p=0.186). Conclusions: The primary indication for IOL explantation or exchange was pseudophakic bullous keratopathy in the AC IOL group and was dislocation or decentration in the PC IOL group. PC IOL explantation or exchange is safe and improves visual acuity.Öğe Intraoperative Corneal Thickness Monitoring During Corneal Collagen Cross-Linking With Isotonic Riboflavin Solution With and Without Dextran(Lippincott Williams & Wilkins, 2014) Oltulu, Refik; Satirtav, Gunhal; Donbaloglu, Meryem; Kerimoglu, Hurkan; Ozkagnici, Ahmet; Karaibrahimoglu, AdnanPurpose: The aim of this study was to analyze and compare corneal thickness changes during corneal collagen cross-linking procedures performed with isoosmolar riboflavin solution with 20% dextran and without dextran in corneal ectatic diseases. Methods: The patients in this study were analyzed in 2 groups: group 1 receiving riboflavin solution containing 20% dextran and group 2 receiving dextran-free riboflavin solution. Corneal thickness measurements were obtained with ultrasonic pachymetry at 6 different time points: preoperatively and at 0, 15, 30, 45, and 60 minutes after epithelial removal and initiation of ultraviolet A irradiation. Results: Twenty-seven eyes of 27 patients with progressive keratoconus were included in the study. In group 1 (n = 13), the mean preoperative thinnest pachymetric readings were 469.3 +/- 8.5 mu m, which decreased to 423.8 +/- 8.9 mu m after deepithelization and further decreased to 385.9 +/- 10.9 mm at 15 minutes. The corneal thickness assumed a steady course at the 30-, 45-, and 60-minute measurements (378.9 +/- 9.8 mu m, 384.5 +/- 10.5 mu m, and 396.7 +/- 9.4 mu m, respectively). The initial change was statistically significant (P < 0.01). In group 2 (n = 14), the corneal thickness decreased from 459.4 +/- 3.8 mu m to 414.7 +/- 2.6 mu m with deepithelization, after which it increased steadily with the initiation of the dextran-free riboflavin solution. The final measurement in group 2 was 474.1 +/- 9.4 mu mm; the increase at each time point was statistically significant when compared with the previous measurement (P < 0.01). Conclusions: Using isoosmolar riboflavin solution without dextran causes a steady increase in the corneal thickness during the cross-linking procedure, as opposed to riboflavin with dextran. This result might be beneficial in broadening the spectrum of cross-linking indications in patients with thin corneas.Öğe The outcomes of intravitreal C3F8 gas tamponade combined with laser photocoagulation treatment for optic disc pit maculopathy(Springer, 2022) Mirza, Gunsu Deniz; Mirza, Enver; Satirtav, Gunhal; Kerimoglu, HurkanPurpose To share the anatomical results and visual outcomes of intravitreal gas tamponade combined with laser photocoagulation treatment for optic disc pit maculopathy (ODPM). Methods Intravitreal gas tamponade combined with laser photocoagulation treatment was performed on six consecutive patients with ODPM. A 0.3 mL of 100% perfluoropropane (C3F8) gas was injected intravitreally. The patients were then asked to maintain prone position until the C3F8 gas disappeared. Laser photocoagulation was performed the day after the procedure. The outcomes were determined by spectral-domain optical coherence tomography and best-corrected visual acuity (BCVA). Results In the present study, visual improvement and reduction in serous macular detachment were observed in 83% of the ODPM patients. Complete retinal reattachment was achieved in 66% of the ODPM patients. In one patient, no regression was observed after the repeated treatment, and pars plana vitrectomy was performed. The final BCVA improved in five eyes and unchanged in one eye. No postoperative complications were observed during the follow-up period in any patient. Conclusions Intravitreal C3F8 gas tamponade combined with laser photocoagulation procedure is an effective, minimally invasive, and cost-effective treatment method for ODPM.Öğe Relationship of inferior oblique overaction to macular and subfoveal choroidal thickness(Mosby-Elsevier, 2015) Ersan, Ismail; Oltulu, Refik; Altunkaya, Orhan; Satirtav, Gunhal; Arikan, Sedat; Donbaloglu, Meryem; Ozkagnici, AhmetPURPOSE To evaluate the macular and subfoveal choroidal thickness of eyes with inferior oblique muscle overaction (IOOA) using enhanced depth imaging spectral domain optical coherence tomography (EDT SD-OCT). METHODS The measurements of macular and subfoveal choroidal thickness obtained by EDI SD-OCT of patients with IOOA (24 patients) were compared with those of age- and sex-matched controls (25 subjects). RESULTS There were no morphological abnormalities of the macula in patients with IOOA or in control subjects. There were no statistically significant differences in macular and subfoveal choroidal thickness between the eyes with IOOA and the eyes of the control subjects (P > 0.05). When the patients with IOOA were assigned to two distinct groups according to the degree of IOOA, the macular thickness did not differ between groups (P = 0.66), whereas subfoveal choroidal thickness measures were significantly lower in eyes with severe IOOA compared to eyes of the controls (P = 0.01). CONCLUSIONS IOOA has no effect on the morphology and the thickness of the macula. Severe IOOA seems to be related to thinning of subfoveal choroid due to possible external mechanical effect.Öğe RELATIONSHIP OF INFERIOR OBLIQUE OVERACTION TO MACULAR AND SUBFOVEAL CHOROIDAL THICKNESS REPLY(Mosby-Elsevier, 2016) Ersan, Ismail; Oltulu, Refik; Altunkaya, Orhan; Satirtav, Gunhal; Arikan, Sedat; Donbaloglu, Meryem; Ozkagnici, Ahmet[Abstract Not Availabe]
