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Öğe Antidepressants and menstruation disorders in women: a cross-sectional study in three centers(Elsevier Science Inc, 2012) Uguz, Faruk; Sahingoz, Mine; Kose, Seyit Ali; Ozbebit, Ozgur; Sengul, Cem; Selvi, Yavuz; Sengul, Ceyhan BalciObjective: The relationship between menstruation disorders and antidepressant drugs usage in women remains unclear. In this study, we aimed to investigate the incidence rate of antidepressant-related menstruation disorders and to examine whether or not antidepressant use is associated with menstrual disorders in women. Methods: The study sample was gathered from three centers and four hospitals. A total of 1432 women who met the criteria of inclusion were included in the study. The sample was divided into two groups: the antidepressant group (n=793) and the control group (n=639). The menstruation disorders were established with reports from the study participants on the basis of related gynecological descriptions. Results: The prevalence of menstrual disorders was significantly higher in the antidepressant group (24.6%) than the control group (12.2%). The incidence of antidepressant-induced menstruation disorder was 14.5%. The antidepressants most associated with menstrual disorders were paroxetine, venlafaxine, sertraline and their combination with mirtazapine. Overall, the incidence rate was similar in women receiving selective serotonin reuptake inhibitors and serotonin noradrenaline reuptake inhibitors. Conclusions: The results of the present study suggest that menstruation disorders are frequently observed in women taking antidepressants and that it appears to be associated with antidepressant use at least in some women. (C) 2012 Elsevier Inc. All rights reserved.Öğe Assessment of the effects of antihistamine drugs on mood, sleep quality, sleepiness, and dream anxiety(Taylor & Francis Ltd, 2014) Ozdemir, Pinar Guzel; Karadag, Ayse Serap; Selvi, Yavuz; Boysan, Murat; Bilgili, Serap Gunes; Aydin, Adem; Onder, SevdaObjective. There are limited comparative studies on classic and new-generation antihistamines that affect sleep quality and mood. The purpose of this study was to determine and compare the effects of classic and new-generation antihistamines on sleep quality, daytime sleepiness, dream anxiety, and mood. Methods. Ninety-two patients with chronic pruritus completed study in the dermatology outpatient clinic. Treatments with regular recommended therapeutic doses were administered. The effects of antihistaminic drugs on mood, daytime sleepiness, dream anxiety, and sleep quality were assessed on the first day and 1 month aft er. Results. Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine. Pheniramine and rupatadine were found to be associated with daytime sleepiness and better sleep quality. UKU side effects scale scores were significantly elevated among outpatients receiving pheniramine. Classic antihistamines increased daytime sleepiness and decreased the sleep quality scores. New-generation antihistamines reduced sleep latency and dream anxiety, and increased daytime sleepiness and sleep quality. Conclusion. Both antihistamines, significantly increased daytime sleepiness and nocturnal sleep quality. Daytime sleepiness was significantly predicted by rupadatine and pheniramine treatment. Cetirizine and hydroxyzine, seem to have negative influences on mood states. Given the extensive use of antihistamines in clinical settings, these results should be more elaborately examined in further studies.Öğe Association between endocrinological, immunological and psychosocial variables in psoriasis patients(Edizioni Minerva Medica, 2016) Bilgic, Ozlem; Bilgic, Ayhan; Sivrikaya, Abdullah; Selvi, Yavuz; Unlu, Ali; Altinyazar, Hilmi C.BACKGROUND: There is limited data concerning the relationship between psychosocial problems of psoriasis patients and the function of their hypothalamic-pituitary-adrenal (IPA) axis and immunologic markers. This study aimed to determine serum levels of basal cortisol and adrenocorticotropic hormone (ACTH) and circulating levels of various cytokines and chemokines and their association with psychological measures in psoriasis patients. METHODS: Serum concentrations of endocrinological and immunological variables were quantified, and psychiatric questionnaires were completed. RESULTS: In psoriasis patients, serum levels of ACTH, TNF-a, IL-6, IL-23, CCL-17, CCL-27, CCL-20 and CXCL-9, current psychiatric symptoms and childhood neglect scores were all higher than in controls. In addition, in psoriasis patients, physical neglect scores were related to lower basal cortisol, whereas recent stressful life events were related to higher IL-6, IL-23 and CCL-20 levels. CONCLUSIONS: The exposure to stressful life events in childhood and just before a flare-up of psoriasis may be related to altered function of the HPA axis and an immune dysregulation in psoriasis.Öğe Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder(Physicians Postgraduate Press, 2015) Ozdemir, Pinar Guzel; Boysan, Murat; Smolensky, Michael H.; Selvi, Yavuz; Aydin, Adem; Yilmaz, EkremObjective: Phototherapy, ie, bright light therapy, is an effective and safe treatment of major depressive disorder (MDD). It exerts rapid mood-elevating activity, similar to antidepressant medications, most likely mediated through both monoaminergic and circadian system melatonergic mechanisms. We assessed the efficiency of bright light therapy as an adjuvant treatment to antidepressant pharmacotherapy in patients with severe MDD randomized by Hamilton Depression Rating Scale (HDRS) score to either (1) 150 mg venlafaxine hydrochloride daily at 7: 00 am or (2) 150 mg venlafaxine plus 60-minute light of 7000 lux the initial week of clinical management (venlafaxine + bright light therapy) daily at 7: 00 am. Method: 50 inpatients with severe MDD at the Psychiatry Clinic of Yuzuncu Yil University Training and Education Hospital participated. The study, which was conducted from January 2013 through June 2014, entailed patients diagnosed with severe MDD based on DSM-IV-TR for the first time. Mood states were assessed by the HDRS, Profile of Mood States (POMS), and Beck Depression Inventory (BDI) before treatment and at 1, 2, 4, and 8 weeks of treatment. Results: On the basis of the HDRS score as the primary outcome variable, both strategies significantly improved depression and negative mood states already at the first treatment week (P < .001). Differences in therapeutic effects by treatment strategy were remarkable at the second and fourth weeks of clinical management (P = .018 and P = .011, respectively), with beneficial effects continuing until trial Conclusion. Those treated with venlafaxine + bright light therapy evidenced significantly lower HDRS depression scores (P < .05) as well as BDI scores (P < .05) and POMS negative mood states scores (depression-dejection, tension-anxiety, anger-hostility, fatigue-inertia, and confusion-bewilderment subscales; all P < .05) after the second week. At week 4 of the trial, 19 (76%) of the 25 venlafaxine + bright light therapy patients versus just 11 (44%) of the 25 venlafaxine patients (P < .05) attained the target goal of treatment, a HDRS score = 13, indicative of mild depression, and, although not statistically significant in our small sample study (P = .36), at week 8, 76% of venlafaxine + bright light therapy patients (n = 19) versus just 64% of the venlafaxine patients (n = 16) experienced complete remission of depression (HDRS score = 7). Conclusions: Both venlafaxine and venlafaxine + bright light therapy treatment strategies significantly reversed the depressive mood of patients with severe MDD; however, the latter induced significantly stronger and more rapid beneficial effects. Future longer-term studies with large sample sizes, nonetheless, are required to confirm and generalize these results to patients of diverse ethnicities and cultures with both severe and mild MDD. (C) Copyright 2015 Physicians Postgraduate Press, Inc.Öğe Dissociative Symptoms Secondary to Piracetam: A Case Report(2013) Aydın, Adem; Güzel Özdemir, Pınar; Selvi, Yavuz; Uğuz, Faruk; Çetinkaya, NuralayPirasetam nöroloji pratiğinde sık kullanılan gama-ami- nobütirik asit türevi bir ilaçtır. Pirasetamın antitrom- botik, nöroprotektif ve bilişsel işlevleri düzeltici bir özellikleri vardır. Vertigo pirasetamın kullanım endikasyonlarından biridir. Disosiyasyonun etyolojisi tam olarak aydınlatılamamıştır. Yapılan ilaç çalışmalarında ortaya çıkan temel disosiyatif semptom depersonali- zasyondur. Bu yazıda periferik vertigo tanısı alan ve ekleme tedavisi olarak pirasetam eklenmiş ancak kullanımından hemen sonra depersonalizasyon ve derealizasyon gibi disosi- yatif semptomlar gelişen ve pirasetamın kesilmesinden sonra bu şikâyetlerin kaybolduğu bir olgu sunumu yapılmıştır.Öğe The Effects of Sleep Deprivation on Dissociation and Profiles of Mood, and Its Association with Biochemical Changes(Galenos Yayincilik, 2015) Selvi, Yavuz; Kilic, Sultan; Aydin, Adem; Ozdemir, Pinar GuzelIntroduction: Sleep deprivation is a method, which has being used in order to comprehend the functions of sleep both in healthy individuals and for the patients of depression with in treatment, for a long time. The objective of our present study is to examine the relation between hormonal values, which are known for being related to the effects of these said changes determined in the mood, dissociation and thought suppression in healthy individuals after one night of sleep deprivation implementation. Methods: One night sleep deprivation was performed on a total of thirty-two healthy volunteers (16 males and 16 females) who were included in the study. Blood samples were taken from the individuals before and after sleep deprivation implementation in order to determine cortisol, dehydroepiandrosterone-sulfate (DHEA-S) and Thyroid Functions' Levels tests. In order to evaluate the effects of the sleep deprivation on moods, White Bear Suppression Inventory (WBSI) has been conducted, with an aim of evaluating thought suppression, Profile of Mood States (POMS), Dissociative Experiences Scale (DES) with a purpose of realizing any dissociation tendency. Results: On the individuals who have been implemented for sleep deprivation, a decrease on depression and vigor-activity sub-scales values was detected, and an increase was determined on fatigue sub-scales values of POMS. While the values of DES were found to have been statistically increased after sleep deprivation, also a significant decrease was determined on WBSI values. Even if there hasn't been any significant statistical change determined on cortisol levels after sleep deprivation, yet there had been some significant changes detected on Thyroid Stimulating Hormone (TSH), fT3, fT4, and DHEA-S levels. Decrease in POMS depression sub-scale values and increase on fatigue sub-scale values were determined on the individuals whose sT4 levels were found to be increased significantly in statistic manner after the sleep deprivation. Conclusion: According to the results of our study, sleep deprivation for one night was determined to cause decrease on depressive mood, increase on dissociative symptoms and to lower the tendency of suppressing the unwanted thoughts, consciously. The fact of being obtained lower depression values, on the individuals with the increased DHEA-S levels after the sleep deprivation meets with the information claiming that the high DHEA-S levels may be deemed as protectors against the negative effects of the stress.Öğe Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-? peptide in high-fat and high-sucrose-fed rats(Cambridge Univ Press, 2017) Selvi, Yavuz; Gergerlioglu, Hasan Serdar; Akbaba, Nursel; Oz, Mehmet; Kandeger, Ali; Demir, Enver Ahmet; Yerlikaya, Fatma HumeyraObjective: The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. Methods: In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n = 16) and standard housing condition (n = 24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid beta-peptide (A beta) (1-40), A beta(1-42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE. Results: The EE decreased the A beta(1-40), A beta(1-42), APP, and tau levels in high-fat and high-sucrose-fed rats. Conclusion: This observation shows that EE may rescue diet-induced amyloid and tau pathology.Öğe Sleep Interventions in the Treatment of Schizophrenia and Bipolar Disorder(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2021) Gica, Sakir; Selvi, YavuzDue to the effects of sleep on the central nervous system, it is thought that sleep disorders have a special importance in the onset, course and treatment of psychiatric diseases. Although the negative effects of sleep problems on the occurrence, recurrence and clinical course of psychiatric disorders are well known, it is reported that clinicians do not spend enough time for sleep problems in practice. This may be related to the fact that patients underreport their complaints for various reasons, insufficient examination time, and clinicians lack of knowledge about the importance of the subject. Pharmacotherapy, psychological and behavioral interventions are options among the therapeutic approaches to sleep problems. But, it seems that clinicians tend to prefer pharmacological approaches for the treatment of sleep problems. However, it is important to choose the appropriate treatment option with considering the method preferred by the patients, who already use many and high doses of pharmacological agents, the nature of the psychiatric disorder and the sleep problem. In this context, chronotherapeutic approaches such as bright light, sleep deprivation, interpersonal relations and social rhythm therapy, and cognitive behavioral therapy techniques adapted for patients with bipolar disorder can be used in the treatment of suitable patients. In this article, the current literature about sleep-related problems observed in patients with schizophrenia and bipolar disorder is reviewed comprehensively with presenting clinical phenotypes and treatment approaches.Öğe Uyku Yoksunluğunun Duygudurum Profili ve Dissosiyasyon Üzerine Etkisi ve Biyokimyasal Değişimlerle İlişkisi(2015) Selvi, Yavuz; Kılıç, Sultan; Aydın, Adem; Güzel Özdemir, PınarAmaç: Uyku yoksunluğu hem uykunun fonksiyonlarının anlaşılması için sağ-lıklı bireylerde hem de depresif hastalarda tedavi amacıyla uzun yıllardır uygulanan bir yöntemdir. Çalışmamız, sağlıklı bireylerde bir gecelik uyku yoksunluğunun duygudurum, dissosiyasyon ve düşünce supresyonu üzeri-ne etkisi ile bu değişkenlerle ilişkili olduğu bilinen hormonal değerler ara-sındaki ilişkiyi incelemeyi amaçlamaktadır. Yöntem: Çalışmaya katılım şartlarını taşıyan 16'sı erkek 16'sı kadın 32 sağ-lıklı bireye bir gecelik total uyku yoksunluğu uygulandı. Bireylerden uyku-suzluk öncesi ve sonrası kortizol, Dihidroepiandosteron-Sülfat (DHEA-S) ve Tiroid Fonksiyon Testleri (TFT) için kan örnekleri alındı. Uyku yoksunlu-ğunun duyguduruma etkisinin değerlendirilmesi için Duygudurumları Pro-fili (DDP), dissosiyatif belirtiler için Dissosiyatif Yaşantılar Ölçeği (DES) ve düşünce supresyonunun değerlendirilmesi amacıyla Beyaz Ayı Supresyon Envanteri (BASE) uygulandı. Bulgular: Uyku yoksunluğu uygulanan bireylerde DDP'nin depresyon ve dinçlik-aktivite alt ölçek puanlarında düşme, yorgunluk puanlarında yük-selme görüldü. DES puanları uyku yoksunluğu sonrası istatistiksel olarak önemli derecede artarken, BASE puanlarında anlamlı bir azalma tespit edildi. Uyku yoksunluğu sonrası kortizol seviyesinde istatistiksel olarak an-lamlı bir değişim elde edilememişse de; Tiroid Stimülan Hormon (TSH), serbest T3 ve T4 (sT3, sT4) ve DHEA-S seviyelerinde anlamlı derecede artış tespit edildi. DDP depresyon alt ölçek puanında azalma ve yorgunluk alt ölçek puanında artma, uyku yoksunluğu sonrası sT4 seviyesi artan bi-reylerde istatistiksel olarak anlamlı bulundu. Sonuç: Çalışmamızın sonuçlarına göre bir gecelik uyku yoksunluğu dep-resif duygudurumda azalma, dissosiyatif belirtilerde artış ve istenmeyen düşüncelerin bilinçli olarak bastırılması eğiliminin azalmasına yol açmıştır. Uyku yoksunluğu sonrası DHEA-S seviyeleri artan bireylerde daha düşük depresyon puanlarının elde edilmesi, yüksek DHEA-S seviyelerinin stresin olumsuz etkisine karşı koruyucu etkisi olabileceği bilgisiyle örtüşmektedir.Öğe Validation of the Turkish Version of the Obsessive-Compulsive Inventory-Revised (OCI-R) in Clinical and Non-Clinical Samples(2014) Aydın, Adem; Boysan, Murat; Kalafat, Temel; Selvi, Yavuz; Beşiroğlu, Lütfullah; Kağan, MücahitIntroduction: The Obsessive-Compulsive Inventory-Revised (OCI-R) is a widely used self-report instrument developed to overcome the problems with the available instruments. The aim of this study was to assess the psychometric properties of the revised Obsessive Compulsive Inventory (OCI-R) in Turkish sample. Methods: The psychometric properties of the Turkish version of the Obsessive-Compulsive Inventory-Revised (OCI-R) were assessed in clinical samples (n44 for patients with obsessive-compulsive disorder (OCD), and n44 for patients with major depression (MD) and a non-clinical student sample (n287). Results: The confirmatory factor analysis demonstrated that the original six-factor structure was valid in the Turkish sample. The overall and each of the subscales showed moderate to good internal consistency and convergent validity as well as test-retest reliability. However, the Cronbachs alpha was excessively low for the hoarding subscale in the OCD group. The total and subscale scores of the OCI-R satisfied at discriminating patients with OCD from both patients with MD and healthy controls, with an exception of the neutralizing subscale. Conclusion: The Turkish version of the OCI-R did not reveal sound psychometric properties. Findings are discussed in the light of current theoretical considerations.