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Öğe Acral chilblain-like lesions following inactivated SARS-CoV-2 vaccination(Wiley, 2021) Temiz, Selami Aykut; Abdelmaksoud, Ayman; Dursun, Recep; Vestita, Michelangelo[Abstract Not Availabe]Öğe Analysis of Consultation Cases Referred from Pediatrics Department to Dermatology Outpatient Clinic: Retrospective Study(Marmara Univ, Inst Health Sciences, 2019) Daye, Munise; Temiz, Selami Aykut; Durduran, Yasemin; Balevi, Sukru; Dursun, Recep; Ataseven, Arzu; Ozer, IlkayObjective: There are a few studies in the literature about dermatology consultations requested from Pediatrics Department. In the present study, it was aimed to assess the clinical features, pre-diagnosis and dermatologic diagnosis of patients consulted to the Dermatology Department from Pediatrics Department, and also to detect possible different approaches between the clinics. Methods: The list of dermatology consultations requested from Pediatrics Department between 1 September 2016 and 1 September 2017 were retrospectively evaluated by means of pre-diagnosis, dermatological diagnosis and unit consultations. Results: The mean age of patients was 7.4 +/- 5.3 years. Of the 628 patients, 52.1% were males, and 85% of the consultations were requested from outpatient clinics and 15% were from the inpatient clinics. Among all consultations 28.7% general pediatrics unit and 17.5% pediatric emergency unit required consultations. The most common diagnosis reported from Dermatology Department were eczema (28.2%), viral diseases (13.2%), parasitic diseases (8.4%) and fungal diseases (5.4%). Although, the ratio of an accurate pre-diagnosis was significantly higher in consultations requested from the inpatient clinics than those from outpatient clinics(p<0.001), 42.7% of the patients were referred to Dermatology Outpatient Clinic with an incorrect pre-diagnosis. Conclusion: Almost half of the patients, who were referred to Dermatology consultation, were diagnosed with incorrect pre-diagnosis. It was seen that pediatricians were difficult to recognize dermatoses. The awareness of Pediatric Dermatology Department should be raised for both specialties.Öğe Arthritis in Hand Joints due to Acitretin: A Rare Case Report(Erciyes Univ Sch Medicine, 2020) Temiz, Selami Aykut; Dursun, RecepBackground: Lichen planus is a skin disease that may last for years, mainly affecting the skin surface and mucous membranes (such as the oral and genital mucosa), and more rarely, on the nails and hairs. Systemic acitretin is an effective therapeutic agent used in the treatment of lichen planus. The skeletal toxicity of retinoids is controversial. Because skeletal toxicity cannot be demonstrated with acitretin, radiological monitoring is not recommended. Case Report: A 24-year-old male patient was admitted to our dermatology outpatient clinic with hand metacarpophalangeal, proximal interphalangeal joint swelling, and pain, who was in the third month of systemic acitretin treatment for oral lichen planus. In our case, another cause of etiologic could not be detected, and arthritis due to acitretin was considered. Conclusion: As a result, it should not be forgotten that acute arthritis may rarely occur during the use of acitretin and should not be overlooked by the clinician.Öğe Arthritis in Hand Joints due to Acitretin: A Rare Case Report(Erciyes Univ Sch Medicine, 2020) Temiz, Selami Aykut; Dursun, RecepBackground: Lichen planus is a skin disease that may last for years, mainly affecting the skin surface and mucous membranes (such as the oral and genital mucosa), and more rarely, on the nails and hairs. Systemic acitretin is an effective therapeutic agent used in the treatment of lichen planus. The skeletal toxicity of retinoids is controversial. Because skeletal toxicity cannot be demonstrated with acitretin, radiological monitoring is not recommended. Case Report: A 24-year-old male patient was admitted to our dermatology outpatient clinic with hand metacarpophalangeal, proximal interphalangeal joint swelling, and pain, who was in the third month of systemic acitretin treatment for oral lichen planus. In our case, another cause of etiologic could not be detected, and arthritis due to acitretin was considered. Conclusion: As a result, it should not be forgotten that acute arthritis may rarely occur during the use of acitretin and should not be overlooked by the clinician.Öğe Assessment of ELR, NLR, MPV, and CRP Levels in Patients With Acne Vulgaris(Galenos Publ House, 2022) Daye, Munise; Temiz, Selami Aykut; Ozturk, Elif Nur Yildirim; Isik, BegumBACKGROUND/AIMS: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. The relationship between some of the hematological parameters active in inflammation such as the neutrophil/lymphocyte ratio (NLR), the mean platelet volume (MPV), and C-reactive protein (CRP) has been demonstrated. In recent years, eosinophil cells have been shown to be associated with inflammation, and the eosinophil/lymphocyte ratio (ELR) has been shown to be an indicator of inflammation in some diseases. In this study, we aimed to evaluate the relationship between the ELR, NLR, MPV, and CRP levels, which are indicators of systemic inflammation, with acne severity parameters in patients with acne vulgaris. MATERIALS AND METHODS: A prospective study was planned with patients in our clinic who were diagnosed with acne vulgaris, who required routine blood parameters, and whose global acne score was calculated. The relationship between these parameters, which are an indicator of systemic inflammation and acne severity, was investigated. RESULTS: In our findings, MPV was found to be the strongest hematological marker for acne severity and inflammation. There was a significant difference between acne severity and ELR, and this difference was higher in the severe acne group. CONCLUSION: As far as we are aware, there has been no study on ELR levels in acne to date; this is the first study to evaluate this rate. Based on our findings, it is thought that ELR increases with the severity of acne and can be accepted as an indicator. In this context, we believe that there is a need for controlled studies involving the role of eosinophils in blood, tissue, and inflammation in the pathogenesis of acne. It is possible that the role of eosinophils in pathogenesis will explain itch-dominated acne patients and may also lead to the development of new targets for treatment.Öğe Behçet tanısı alan hastaların paterji pozitif ve negatif alanlarının histopatolojik olarak karşılaştırılması(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 2020) Temiz, Selami Aykut; Balevi, ŞükrüBehçet hastalığı, atak ve remisyonlarla kronik bir seyir izleyen, esas patolojisi hemen her organı ve sistemi tutabilen inflamatuar bir vaskülit tablosudur. Paterji reaksiyonu, hastalık için özgün bir klinik bulgu olup tanı kriterlerinin vazgeçilmez bir elemanıdır. Literatürde yeni tanı Behçet hastalarında negatif paterji testi ile pozitif paterji testinin histopatolojisini karşılaştıran bir çalışma bulunmamaktadır. Çalışmamızda, paterji pozitif ve paterji negatif olan yeni tanı konulan Behçet hastalarımızın, paterji pozitif ve paterji negatif reaksiyon bölgelerinden aldığımız cilt biyopsilerinin histopatolojik bulgularının karşılaştırılması amaçlandı. Behçet hastalığının önemli bir bulgusu olan vaskülitin paterji histopatolojisinde sıklığının araştırılması birincil hedefti. Gereç ve Yöntem Deri ve Zührevi Hastalıkları polikliniğine başvuran ve Uluslararası Çalışma Grubu kriterlerine göre Behçet hastalığı tanısı konulan 42 paterjisi pozitif, 46 paterjisi negatif olan toplam 88 hasta değerlendirmeye alındı. Çalışmada yer alan hastalarının demografik özellikleri, başvuru şikayeti, aile öyküsü, paterji testi pozitiflik oranı ve direkt immünfloresan işleminin sonuçları not edildi. Paterji testi pozitif ve paterji testi negatif olan hastaların histopatolojilerinde vaskülit mi, vaskülopati mi olduğu tespit edildi ve iltihabi reaksiyon histopatolojik şiddetine göre bir ile üç arasında skorlandı. Histopatolojide perivasküler alandaki nötrofil, lenfosit, eozinofil ve mast hücrelerinin sayımı yapılarak yüzde olarak kaydedildi. Bulgular Çalışmaya katılan 88 Behçet hastasının 45'i kadın, 43'ü erkek hastaydı. Olguların yaş ortalaması 30,17±8,65 idi. Paterji testi pozitif 42 hastanın 23'ünde histopatolojik olarak vaskülit saptanırken, paterji testi negatif 46 hastanın 18'inde histopatolojik olarak vaskülit saptandı. Paterji testi pozitif olanlarda histopatolojisinde vaskülit görülme oranı paterji testi negatif olanlara göre istatistiksel olarak anlamlı farklı değildi (p=0,14). Çalışmamızda özellikle erkek cinsiyet ile üveit arasında ilişki sınırda anlamlı ve paterji pozitifliği ile üveit arasında da ilişki anlamlı saptanmamış olmasına rağmen histopatolojide vaskülit görülmesi ile üveit arasında anlamlı ilişki saptandı (p=0,023). Sonuç Paterji fenomeninin Behçet hastalığının tanısını koymada sensitiviteyi artırdığı ve gerçek hastaları yakalamadaki başarısının oldukça yüksek olduğu bilinmektedir. Fakat değerlendirmenin sadece klinik olarak yapılması testin yanlış pozitif veya yanlış negatif yorumlanması riskini doğurmaktadır. Çalışmamızdan yola çıkan sonuçlarla histopatolojinin paterji testinin klinik olarak şüphe oluşturan ve özellikle negatif paterji testi olan olgularda klinik değerlendirmeye katkı sağlayacağını düşünmekteyiz. Belki de paterji testinin gerçek değeri bu yaklaşımla daha iyi anlaşılabilir.Öğe A case of entecavir-associated bullous fixed drug eruption and a review of literature(2019) Temiz, Selami Aykut; Özer, İlkay; Ataseven, Arzu; Fındık, SıddıkaFixed drug eruption (FDE) is a type of drug reaction characterized by localized erythema, hyperpigmentation, and bullous at the samesite(s), generally observed following every intake of a causative drug. Delayed-type cellular hypersensitivity (Type IVC) is considered toplay a role in FDE etiology. Several antibiotics, barbiturates, oral contraceptives, nonsteroidal anti-inflammatory drugs, laxative-containing phenolphthalein, metronidazole, and quinine are known to be the primary drugs responsible for FDE. Bullous FDE, on the otherhand, is a relatively rare form of FDE. Hepatitis B is a significant worldwide health problem, and entecavir is a common nucleoside(deoxyguanosine) analog used for treating hepatitis B; however, it has various side effects, such as lactic acidosis, myalgia, azotemia,hypophosphatemia, headache, diarrhea, pancreatitis, and neuropathy, and, in rare cases, cutaneous drug eruption. Our aim is to presenta case of entecavir-associated bullous drug reaction, which has not been reported in the literature. Furthermore, we performed a reviewof literature to compile previously reported entecavir-associated drug reactions.Öğe A Case of Nodular Cystic Acne Treated with Systemic Dapsone(Galenos Yayincilik, 2020) Daye, Munise; Temiz, Selami AykutDapsone is an aniline derivative from synthetic sulfones. The mechanism of action of dapsone is obscure in inflammatory diseases; however, it is suggested to inhibit neutrophil chemotaxis and lysosomal enzymes. Acne vulgaris (AV) is a chronic inflammatory disorder of the pilo-sebaceous unit. Herein we report a pediatric patient who was started systemic isotretionin due to severe nodular cystic AV but could not continue due to elevated liver enzymes and well response to systemic dapsone treatment. We consider that per-oral dapsone treatment may be a well-tolerated and effective treatment option in patients with moderate/severe, frequently recurring AV which is irresponsive to conventional therapies and may a good alternative to isotretionin particularly in pediatric cases.Öğe A case of nodular scabies with atypical course(Wiley, 2020) Daye, Munise; Temiz, Selami Aykut; Kilinc, Fahriye[Abstract Not Availabe]Öğe A Case of Staphylococcal Scalded Skin Syndrome in a 1-Year Old Boy with Otitis Media(2018) Temiz, Selami Aykut; Özer, İlkay; Ataseven, Arzu; Fındık, SıddıkaIntroduction: Staphylococcal scalded skin syndrome (SSSS), also known as Ritter’s Disease, is a severe disease seen mostly in newborns and children aged 5 years, and the mortality rate might reach to 4% despite an appropriate treatment. Exfoliative toxins cause intraepidermal separation in the stratum granulosum and lead to a condition that is characterized with widespread epidermolysis all over the body and bullae with positive Nikolsky’s sign. SSSS might be fatal due to loss of skin barrier. Immediate initiation of an anti-staphylococcal drug therapy is required for the treatment of this toxin-dependent disease, which is one of the emergencies of dermatology practices. Case Report: A 1-year-old boy was referred to a dermatology clinic from pediatric emergency service with widespread epidermolysis all over the body, including erosion and bullous formation that had been appeared in the inguinal region. SSSS was suspected in this case, and skin biopsy was performed to confirm the diagnosis. He was hospitalized in the Pediatric Infectious Diseases Service, and treatment comprising intravenous administration of (i.v.) vancomycin (40 mg/kg/day) and 3 gIVIG ( intravenous immunoglobulin) was initiated. Conclusion: Staphylococcus aureus, a rather rare agent of otitis media, is remarkable in terms of causing the complication of SSSS, which is very rare. In our case report, we aimed to remark to this rare condition (association of otitis media and SSSS). Keywords: Staphylococcal scalded skin syndrome, Staphylococcus aureus, otitis media.Öğe Clinical and laboratory assessment for the inflammation role in chronic spontaneous urticaria: A clinical study(Wiley, 2020) Ataseven, Arzu; Durmaz, Koray; Temiz, Selami Aykut; Dursun, RecepChronic spontaneous urticaria (CSU) is triggered by unknown causes. We would like to explore the possible effect of hemogram parameters and several biochemical markers on CSU presence and also the severity of the disease. We also aimed to discuss the relationship between CSU and inflammation associated with these values. The study was planned prospectively. We selected patients already diagnosed with CSU who applied to the dermatology outpatient clinic and healthy controls. The patients and the healthy controls were tested for complete blood count, neutrophil/lymphocytes ratio and platelets/lymphocytes ratio, erythrocyte sedimentation rate, C-reactive protein, serum albumin and total bilirubin and indirect bilirubin levels. Urticaria activity score over 7 days (UAS-7) was calculated for the CSU patients. Forty patients with CSU and 55 healthy subjects were included in the study. Mean white blood cell (WBC) count is 8.37 +/- 2.14 in the patients' group and 7.41 +/- 2.01 in the healthy subjects group. Mean neutrophil (NEU) count is 4.88 +/- 1.65 in the patients' group and 4.19 +/- 1.39 in the healthy subjects group. Mean platelets (PLT) count is 308.48 +/- 88.32 in the patients' group and 268.65 +/- 64.80 in the healthy subjects group. We also detected positive correlations between UAS-7 score-WBC counts and UAS-7 score-NEU counts. Future studies are needed to investigate this possible relationship and confirm these results.Öğe The clinics ofHHV-6 infection inCOVID-19 pandemic: Pityriasis rosea and Kawasaki disease(Wiley-Hindawi, 2020) Dursun, Recep; Temiz, Selami AykutA new type of coronavirus family (SARS-CoV-2), which can be found in humans and animals, with many varieties and clinical symptoms, was first seen in Wuhan, China in late 2019, under the name novel Coronavirus Disease 2019 (COVID-19). In the literature, cutaneous symptoms related to the disease are generally emphasized. However, it is not yet known whether this new SARS-CoV-2 virus, which has entered our lives, plays a role in the etiopathogenesis of dermatological diseases. The patients who were admitted to the dermatology outpatient clinic between 1 April and 15 May 2019, and on 1 April and 15 May 2020 were retrospectively analyzed by searching the hospital automation system and patient files. The reason for the same months to be included in the study was to exclude seasonal effects on the diseases. After pandemic, the number of patients with Pityriasis rosea and Kawasaki disease increased significantly in patients who applied to the dermatology outpatient clinic. Our study is the first study showing Pityriasis rosea increase during the pandemic period. We think that this increase is related to HHV-6 reactivation. Herein, we wanted to draw attention to two diseases in which Human Herpes 6 (HHV-6) was accused in etiopathogenesis: Kawasaki disease and Pityriasis rosea.Öğe Comparison of anti-TNF and IL-inhibitors treatments in patients with psoriasis in terms of response to routine laboratory parameter dynamics(Taylor & Francis Ltd, 2022) Ataseven, Arzu; Temiz, Selami Aykut; Eren, Gullu; Ozer, Ilkay; Dursun, RecepBackground Biological agent treatments represent a relatively new field and their effects on routine laboratory parameters are not fully known as there has been little research in the area. In our study, we aimed to evaluate the differences between the two main biological treatment groups and their effects on routine laboratory parameters. Methods Patients were enrolled when they had received treatment for more than six months with biological treatments between January 2013 and April 2020. The available data on routine laboratory parameters were collected by routine blood tests before the treatment, at three months, and at the final evaluation. Results When the changes in routine laboratory parameters were evaluated by treatment, it was found that the NLR and CRP values decreased statistically significantly in the anti-TNF group compared to the IL inhibitor group. In addition, strong suppression of these inflammation parameters means strong suppression of the immune system response. In addition, AST, ALT, and creatinine values were found to be statistically significantly higher in the anti-TNF group compared to the IL inhibitor group. Conclusions In our study, anti-TNF treatments are shown to be more effective in reducing inflammation parameters while IL antagonists are safer in terms of biochemical parameters.Öğe Could isotretinoin be a protective agent against COVID-19?: A dermatologist perspective(Wiley, 2021) Abdelmaksoud, Ayman; Patil, Anant; Dursun, Recep; Temiz, Selami Aykut; Ayhan, Erhan; Goldust, Mohamad; Vestita, Michelangelo[Abstract Not Availabe]Öğe Cutaneous and Allergic reactions due to COVID-19 vaccinations: A review(Wiley, 2022) Temiz, Selami Aykut; Abdelmaksoud, Ayman; Wollina, Uwe; Kutlu, Omer; Dursun, Recep; Patil, Anant; Lotti, TorelloIntroduction The pandemic caused by the novel coronavirus disease 2019 (COVID-19) has had an unprecedented impact on the overall health and the global economy. Vaccination is currently the most dependable strategy to end the pandemic, despite the slower-than-hoped-for rollout, particularly for low-to-middle-income countries, and the uncertain duration of protection afforded by vaccination. The spike protein of the virus (immunodominant antigen of the virus) is the main target of the approved and candidate SARS-CoV-2 vaccines. This protein binds to the ACE2 receptor of the host cell, initiating the entry of the virus into the cell and the chain of subsequent events ending to Acute Respiratory Distress Syndrome. The safety profile of these vaccines needs is closely assessed. Methods This comprehensive review includes searching the PubMed, EMBASE, and Web of Science databases using the keywords coronavirus, COVID-19, vaccine, cutaneous reactions, allergic reactions, and SARS-CoV-2. Manual searching of reference lists of included articles augmented the research. The research was updated in June 2021. Results In this narrative review, we tried to investigate and discuss the cutaneous and allergic reactions related to SARS-CoV-2 vaccines currently available in the literature. As a result, although COVID-19 vaccines can be reported to develop allergic and anaphylactic reactions, especially after m-RNA vaccines, they remain at a low rate, and it is observed that these reactions may develop more frequently, especially in patients with previous allergies and mast cell disorders. Fortunately, these reactions are generally transient, benign, self-limited. Conclusion Although there is still no definitive evidence, as dermatologists, we must be aware of the possibility of cutaneous reactions, newly diagnosed dermatoses, or exacerbation of existing dermatoses that may develop after the COVID-19 vaccinations.Öğe Cutaneous Mucinosis Case with Characteristic Lion Face Appearance(Aves, 2018) Temiz, Selami Aykut; Dursun, Recep; Ataseven, Arzu; Ozer, Ilkay; Findik, SiddikaCutaneous mucinosis includes a heterogeneous group of skin diseases characterized by the deposition of mucin in the interval of the dermis. Mucin is a protein ordinarily found as part of the dermal connective tissues. Mucin is a mucopolysaccharide produced by mast cells and fibroblasts and includes hyaluronic acid and sulfated glycosaminoglycans. Because hyaluronic acid holds water, in disease states where mucin production is increased, the dermal connective tissue swells, which is defined as myxedematous. Systemic mucin deposition may include systemic involvement; monoclonal gammopathy or paraproteinemia have been detected in the large majority (83.2%) of scleromyxedema cases. A 50-year-old female presented with pruritic, flesh-colored papules spread throughout the body. She also exhibited a characteristic lion face appearance. These lesions had first appeared 18 months before in the neck. The protein electrophoresis and bone marrow biopsy of the patient were normal. Histopathological examination revealed widespread mucin accumulation with alcian blue and colloidal iron stains in the papillary and reticular dermis. Granulomas were not observed with CD68 staining, and no accumulation was observed with amyloid staining. The final diagnosis was cutaneous mucinosis. In this paper we present the case of a patient with generalized primary cutaneous mucinosis without any systemic disease.Öğe Cutaneous Pseudolymphoma Due to Hirudotherapy(2019) Temiz, Selami Aykut; Özer, İlkay; Ataseven, Arzu; Dursun, Recep; Fındık, SıddıkaPseudolymphoma, also known as Jessner’s lymphocytic infiltration, is a benign but usually chronic, T-cell infiltrating diseasewith erythematous papules and plaques usually seen on the skin of the face, neck, and back. The use of leech therapy also knownas hirudotherapy has increased in recent years. Here, we report a 52-year-old male patient who had undergone hirudotherapy inhis neck and developed infiltrating plaques after four months. A skin biopsy confirmed the diagnosis of Jessner’s lymphocyticinfiltration. In parallel with the increasing use of hirudotherapy in recent years, the side-effect reports will likely to increase.Indications and contraindications of hirudotherapy, which is being used officially in hospitals, should be taken into consideration.Öğe Cutaneous reactions after COVID-19 vaccination in Turkey: Questions and answers(Wiley, 2023) Kahraman, Filiz Cebeci; Temiz, Selami Aykut[Abstract Not Availabe]Öğe Cutaneous Vasculitis after Radiotherapy(Aves, 2019) Temiz, Selami Aykut; Ozer, Ilkay; Kanyilmaz, Gul; Ataseven, Arzu; Oltulu, PembeCutaneous vasculitis is a large heterogeneous group of diseases, where blood vessels are targeted by immunological and inflammatory reactions, which are the primary causes of this condition. Infections, medications, systemic collagenosis, chronic diseases, and malignancies are the secondary factors that cause cutaneous vasculitis. Hemangiomas are the most common primary benign tumors of the spinal cordand are rarely symptomatic. The most commonly manifestedsymptom is pain, but in rare cases, cutaneous vasculitis may lead to paraparesis and paralysis. Radiotherapy (RT) is a safe and effective treatment for symptomatic spinal cord hemangiomas. A 44-year-old male patient was admitted to our dermatology polyclinic with a complaint of a bilateral rash on both legs that had lasted for 1 week. The medical history of the patient included no disease other than a sacral hemangioma with symptomatic pain, for which the patient had been treated with 4500 cGy curative radiotherapy 1 month previously. In our case, it was thought that cutaneous vasculitis was caused by the radiotherapy without any other triggering factor. A skin biopsy was taken to arrive at a definite diagnosis, and in the histopathological examination, abundant amounts of extra-red blood cells and lymphocytes were observed, along with endothelial profiling in superficial vessels; all of which are findings consistent with vasculitis. The patient was diagnosed with cutaneous vasculitis, both clinically and histopathologically. To the best of our knowledge, radiotherapy as a cause of vasculitis has been the subject of very few studies in the literature to date. In this regard, the present report describes a case of cutaneous vasculitis as a possible immune-related side effect of RT.Öğe Dapsone for the treatment of acne vulgaris: do the risks outweigh the benefits?(Taylor & Francis Ltd, 2022) Temiz, Selami Aykut; Daye, MuniseDapsone is a 4,4'-diamino diphenyl sulfone compound and an aniline derivative from synthetic sulphones. Sulphonamides were first used in humans as antimicrobial agents to treat streptococcal infections. Dapsone derived from sulphonamides was first used in the treatment of leprosy in 1940. Today, Dapsone treatment is among the treatment options for many dermatological diseases. Acne vulgaris is a chronic inflammatory disease, which causes scar formation and changed pigmentation. Acne affects 85% of teenagers, but can occur at any age and can last into adulthood and even lifelong. Through its antimicrobial, anti-inflammatory, and antioxidant effects, dapsone treatment (local or systemic) can also be used in the treatment of acne. Dapsone treatment can cause a variety of side effects that can be categorized as pharmacological, dose-related, allergic, or idiosyncratic reactions. In this review article, the risks and benefits of using dapsone treatment in acne vulgaris will be evaluated in light of the literature.
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