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Öğe Comparison of Bone Dust With Other Types of Bone Grafts for Cranioplasty(Lippincott Williams & Wilkins, 2014) Karamese, Mehtap; Toksoz, Mustafa Rasid; Selimoglu, Muhammed Nebil; Akdag, Osman; Toy, Hatice; Tosun, ZekeriyaPurpose: Split calvarial bone graft is preferred in the reconstruction of calvarial defects. However, it is not feasible for use in some challenging cases and in children. Particulate bone graft containing viable osteoblasts could be an attractive alternative. Materials and Methods: A total of 32 female rats were randomly separated into 4 groups. Full-thickness bone graft from rat calvaria was harvested in diameters of 8 x 8 mm. In group 1, the periosteum and skin were closed without any bone graft; bone dust particles were placed in group 2; bone fragments were placed in group 3; and full-thickness cranial bone graft was placed in group 4. After 12 weeks, all rats were killed. Degrees of resorption, foreign body reaction, and bone spicule length were assessed histologically, and an immunohistochemical study was used to show bone graft viability. Results: In graft viability, osteogenesis, and osteoblastic differentiation, groups 3 and 4 were similar and superior to groups 1 and 2. No osteoblastic activity and no viable bone dust were detected in groups 1 and 2. Resorption was observed in every preparate that contains bone tissue, and foreign body reaction was prominent in small bone groups, such as in group 2. Conclusions: In the full-thickness cranial bone graft group and the bone fragment group, the preservation of bone viability was obviously superior to the bone dust group and the periosteum-only group. In conclusion, bone dust behaved like the periosteum and could not create new bone, whereas bone particles behaved like the full-thickness cranial bone graft and were capable of preserving viability.Öğe DMEM ve HAMS F-12 sıvıları ile deri grefti yaşayabilirliğinin araştırılması(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 2000) Tosun, Zekeriya; Savacı, NedimKlasik bir bilgi olarak deri greftleri izotonik serum içinde saklanmakta ve gerek otogreft, gerekse allogreft olarak kullanılabilmektedir. Saklanan bu greftlerin hücre yaşayabilirliğinin maksimum düzeyde tutulması klinik başarıyı artıracaktır. Ayrıca greft total keratinosit sayısını gündeme getirerek önemli bir parametre çalışıldı. Yaşlan 25-35 arasında değişen 26 hastaya ait pannükülektomi materyalleri steril şartlarda elde edilmiştir. 6 materyal mantar kontaminasyonu sebebiyle çalışmaya dahil edilmedi. 36 ml'ye bir (1) cm2 parça gelecek şekilde ve DMEM, Ham's F-12 solüsyonları içinde +4 °C'ye sabitlenmiş buzdolabına konularak 3 hafta saklanmıştır. DMEM ve Ham's F-12 solüsyonları dokular için besleyici özelliğe sahip sıvılardır. Bu sürenin sonunda materyaller PBS ile yıkanarak Tripsin EDTA ile muamele edildi. Epidermis dermişten ayrılarak manyetik karıştırıcı ile karıştırıldı. Bu süspansiyona tripan blue boyası ile viabilite testi yapıldı. DMEM ve Ham's F-12 ile elde edilen sonuçlar birbirine yakın ancak izotonik seruma göre oldukça yüksek bulunmuştur. Bu çalışma ile allogreft ve oto greft saklanmasında viabilitenin yeri olduğu ve başarılı olarak kullanılabileceği gösterilmiş oldu.Öğe EARLY AND LATE TERM MICROSURGICAL FREE FLAP RECONSTRUCTION AND RISKS IN HIGH VOLTAGE ELECTRICAL INJURY(Carbone Editore, 2013) Karabekmez, Furkan Erol; Duymaz, Ahmet; Tosun, Zekeriya; Keskin, Mustafa; Savaci, NedimThe aim of the study is to discuss and compare the early and late micro vascular flap reconstruction's outcomes, importance, risks, advantages and disadvantages with review of our 13 high voltage electrical burn injury cases. Medical records have been reviewed for electrical burns in last three years. 13 cases fitting the criterion were included into the study. Four of them have been hospitalized for late complication such as severe contracture; nine of them have been hospitalized for acute treatment. Five patients had latissimus dorsi muscle flap, three patients had parascapular flap, two patients had latissimus dorsi and scapula osteomusculo-cutaneous flap, two patients had reams abdominis musculocutaneous flap, and one patient had parascapular and scapular flap. Early reconstruction applied group showed a significant difference regarding to flap failure rates. Electrical injuries are more complex than regular burn injuries related with heat, and the reconstruction of these cases also should be special. One of the most important factor for free flap viability in electrical injury cases is surgery timing. All of the complications were seen in the patients who had surgery at 12th and 19th days after the electrical injury. No complication has seen in the group of patients who had surgery on late term period. However microsurgical reconstruction should be considered to cover exposed bony tissues on the extremities in the short term period in order to prevent possible limb shortening procedures.Öğe Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma for Prevention of Alopecia and Other Skin Complications of Radiotherapy(Lippincott Williams & Wilkins, 2021) Evin, Nuh; Tosun, Zekeriya; Aktan, Tahsin Murad; Duman, Selcuk; Harmankaya, Ismail; Yavas, GulerBackground Radiotherapy (RT) involves the use of ionizing radiation in treating malignancies and benign disorders. However, RT damages target and healthy surrounding tissues in a dose-dependent manner. This effectively reduces patient compliance and quality of life, thereby warranting the prevention of RT-induced adverse effects on skin. Adipose-derived stem cells (ASCs) are used to treat RT-induced damage and platelet-rich plasma (PRP) provides a scaffold that potentiates the effects of ASCs. Thus, the aim of this study was to determine the mechanism employed by ASCs and PRP in protecting against RT-induced adverse effects. Methods We have established an immunodeficient mouse transplantation model using which human hair follicular units were implanted. When the follicular units were macroscopically and microscopically mature and anagenic, we administered localized RT. Subsequently, the mice were randomly divided into 4 groups based on the subcutaneous injection of the following to the irradiated transplantation site: saline, PRP, ASCs, and a combination of ASCs and PRP. Next, we used macroscopic and microscopic analyses to determine the protective effects of the injected solutions on skin and hair follicles. Results Adipose-derived stem cells reduced RT-induced adverse effects, such as impaired wound healing, alopecia, skin atrophy, and fibrosis by suppressing inflammation, dystrophy, degeneration, connective tissue synthesis, and apoptosis and increasing cellular proliferation, differentiation, and signaling. Moreover, these effects were augmented by PRP. Conclusions Thus, co-administering ASCs with PRP in mice prevented RT-induced adverse effects and can be tested for use in clinical practice.Öğe Intra-articular platelet-rich plasma injection for the treatment of temporomandibular disorders and a comparison with arthrocentesis(Churchill Livingstone, 2015) Hanci, Mustafa; Karamese, Mehtap; Tosun, Zekeriya; Aktan, Tahsin Murad; Duman, Selcuk; Savaci, NedimBackground: Temporomandibular joint (TMJ) internal derangements are progressive painful conditions and cause joint dysfunction, joint sound, malocclusion, and locking of the mouth. Conservative and invasive techniques can be used for the treatment of TMJ internal derangements. The objective of the present study was to examine the benefit of an intra-articular platelet-rich plasma (PRP) injection and to compare this with arthrocentesis. Methods: Twenty patients (female: male; 15: 5; age 26, 3 +/- 9.3 years) for a total of 32 joints with reducible anterior disc dislocation, as confirmed by Magnetic Resonance Imaging (MRI), were divided into two groups. PRP was used for the study group, and arthrocentesis was used for the control group. Pain intensity, maximal interincisal opening, and TMJ sounds were assessed and compared for evaluation of treatment success. Results: There was a statistically significant reduction in pain intensity and joint sound and an increase in mouth opening in the study group when compared with the control group. Conclusions: This study shows that intra-articular PRP injection for the treatment of reducible disc displacement of the TMJ is a more effective method than arthrocentesis. (C) 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.Öğe A SAFE METHOD IN RHINOPHYMA SURGERY : EXCISION WITH PLASMA BLADE(Medknow Publications & Media Pvt Ltd, 2011) Toksoz, M. Rasid; Selimoglu, M. Nebil; Karamese, Mehtap; Abaci, Malik; Tosun, Zekeriya[Abstract Not Availabe]Öğe VACUUM THERAPY AND PECTORALIS MAJOR MUSCLE FLAP COMBINATION IN TREATMENT OF STERNAL INFECTIONS: A CASE REPORT(Medknow Publications & Media Pvt Ltd, 2014) Karamese, Mehtap; Akdag, Osman; Yildiran, Gokce Unal; Selimoglu, Muhammed Nebil; Gormus, Niyazi; Tosun, ZekeriyaWound infections subsequent to cardiac surgery are challenging surgeons because of being life-threatening situations and these infections are among conditions that require multidisciplinary approach. Antibiotherapy, surgical debride-ments, regional or free flap surgeries are used by multidisciplinary approach in the treatment of sternal wound infections. Beside these known alternatives, some other methods are advanced for wound care. However; sternal instability, ventricular rupture and pneumonia may be mortal in many patient as the course of the disease. In this article, a negative pressure wound therapy and reconstruction with pectoralis major muscle flap was introduced for postoperative mediastinitis occurred in a diabetic, coronary bypass patient. A wound therapy, that controls infection and supplies wound care as an effective treatment alternative for highly mortal mediastinis cases.Öğe Winer's Nodular Calcinosis Mimicking Squamous Cell Carcinoma On The Ear(Wolters Kluwer Medknow Publications, 2017) Karadag, Emine Cigdem; Toy, Hatice; Tosun, ZekeriyaWiner's nodular calcinosis, presenting as an asymptomatic, firm, white, or yellow nodule at birth or during early childhood, is a form of idiopathic calcinosis cutis. Ulceration on Winer's nodular calcinosis is rarely seen. Till date, there is no report in the literature regarding the malignant skin lesion confused with Winer's nodular calcinosis. No similar case or article has been encountered in the Turkish or English literature regarding the malignant skin lesion that might be confused with Winer's nodular calcinosis. The case of a 3-year-old girl with a 3x2 mm, white, ulcerated, nodular lesion on the helix of the left ear is presented here. The lesion was thought to be a squamous cell carcinoma due to the ulceration and appearance, and it was located on the ear, which is frequently exposed to the sun.
