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    Antimicrobial Activity of Different Solutions on Denture Base Materials
    (Georg Thieme Verlag Kg, 2018) Tuncdemir, Ali Riza; Ugur, Ayse Ruveyda; Ozdemir, Bilgen; Kahraman, Kubra T.
    There are a few chemical solutions used for prosthetic cleaning and they have different antimicrobial effects on denture materials. The aim of this study is to evaluate the efficacy of various chemical solutions used in prosthetic cleaning. For this purpose, 40 specimens of polymethylmethacrylate (PMMA-Meliodent, HeraeusKulzer, Hanau, Germany), which is the most commonly used material in conventional prostheses, and 40 specimens of Deflex (Nuxen SRL, Ayacucho 1053 3-A, Cap. Fed. Buenos Aires, Argentina), which is polyamide-containing semi-flexible acrylic, were molded using a template at the laboratory of Dentistry Faculty. Leveling began with abrasive burs and Stones followed by the sanding with medium and thin discs. Surface preparation was done using wet pumice and felt followed by polishing with gypsum-alcohol and rotary soft brush. The evaluated three solutions are Corega cleaning tablets containing alkaline peroxide, 0.2% chlorhexidine gluconate (CG) and 1% sodium hypochlorite (NaOCl). Distilled water was used as the control group. When both groups of polymers were evaluated in respect to the Candida growth after they were kept in liquid containing NaOCl, Corega, and CG, it was observed that only the acrylics that were kept in Corega revealed Candida growth. It was concluded that Corega could not sufficiently inhibit the growth of Candida albicans which is the one of themost common microorganisms in the oral flora of pediatric and elderly patients. NaOCl and CG can be used safely and effectively for denture cleaning.
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    Antimicrobial Activity of Glass Ionomer Cements with Chlorhexidine and Propolis: An In Vitro Study
    (Georg Thieme Verlag Kg, 2019) Tuncdemir, Makbule Tugba; Ugur, Ayse Ruveyda; Ozdemir, Bilgen
    The aim of this study was to evaluate the antibacterial effect of conventional glass ionomer cement with the addition of antibacterial constituents in its liquid preparation. Two groups of glass ionomers prepared with propolis and chlorhexidine and a third group without any additive used as control were sterilized by low-temperature hydrogen peroxide plasma sterilizer at the sterilization unit. Seven to eight disk-shaped restorative materials of each group were placed on the Mueller Hinton Agar with sheep blood 5% v/v, on which Streptococcus mutans inoculated. The plates were incubated at 37 degrees C in 5% CO (2) for 24 to 48 hours. After 24-hour and 48-hour-incubation, inhibition zone diameters of each restorative materials were measured. No distinct inhibition zone was reported; only a slight zone (6 mm) around the contact surfaces of each material was observed after the 24-hour and 48-hour incubations. No significant difference was observed in the inhibition zone diameters between the two test groups and control. Within the limitations of this study, results revealed that there was no antibacterial difference among glass ionomers prepared with propolis and chlorhexidine.
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    Can Monkeypox Infection Be Serious Problem for Children?
    (Georg Thieme Verlag Kg, 2022) Ugur, Ayse Ruveyda; Ozdemir, Mehmet
    [Abstract Not Availabe]
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    Can YKL-40 be an Inflammatory Biomarker in Vitamin D Deficiency?
    (Verlag Hans Huber, 2019) Can, Ummugulsum; Uysal, Saliha; Ugur, Ayse Ruveyda; Toker, Aysun; Aslan, Uysaler; Hidayetoglu, Bahauddin Taha
    Vitamin D deficiency is associated with several non-homeostatic conditions and/or diseases like inflammation, atherosclerosis, cardiovascular disease and mortality. YKL-40 is a glycoprotein, secreted by macrophages, neutrophils and different cell types and it is also associated with inflammation and pathological tissue remodeling. In this study, we aimed to evaluate relationship between the proinflammatory biomarkers YKL-40 and hs-CRP levels and vitamin D deficiency. Our study group includes 45 subjects with vitamin D deficiency (Group 1) (20 M, 25 F; mean age 37.72 +/- 7.70 years) and 40 age and sex-matched healthy subjects with normal serum levels of vitamin D (Group 2) (19 M, 21 F; mean age 39.26 +/- 7.41 years). Plasma 25 (OH) vitamin D levels were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Plasma YKL-40 analysis was performed by ELISA. Serum hs-CRP levels were measured by nephelometric method. Plasma vitamin D levels below 20 ng/mL were accepted as vitamin D deficiency. Although we could not find any significant differences by means of serum hs-CRP levels between Group 1 and Group 2 (2.21 (0.27-11.70); 1.79 (0.16-9.85) mg/L, p = 0.247), plasma YKL-40 levels were significantly higher in group 1 than group2 (70.47 (17.84-198.50); 47.14 (4.80-135.48) ng/mL, p = 0.047). In literature, vitamin D deficiency is associated with inflammation. In our study, we found similar hs-CRP levels between groups and higher YKL-40 levels in group 1. Vitamin D deficiency may be related to high YKL-40 levels in terms of causing chronic inflammation.
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    Investigation of Parvovirus B19 IgM and IgG Positivity Rates in Pediatric Hematology Patients
    (Georg Thieme Verlag Kg, 2018) Gorkem, Aysun; Ugur, Ayse Ruveyda; Ozdemir, Mehmet; Feyzioglu, Bahadir; Baykan, Mahmut
    Human parvovirus B19 is a frequent etiologic agent causing erythema infectiosum in children. It has recently been suggested that parvovirus B19 may be latent after infection and cause reactive infections especially in immunosuppressed patients with hematological problems. In this study, we aimed to investigate the parvovirus B19 immunoglobulin M (IgM) and immunoglobulin G (IgG) seropositivity rates of patients evaluated in a pediatric hematology clinic. We retrospectively screened the laboratory results of parvovirus B19 IgM and IgG antibody assays of children less than 18 years, who consulted pediatric in-and-outpatient clinics between 2013 and 2016. Parvovirus B19 IgM and IgG antibodies were investigated in serum samples by using enzymelinked immunosorbent assay method in the Medical Microbiology Laboratory. Parvovirus B19 IgM antibodies were detected in 109 of 602 patients attending pediatric hematology clinics (18.1%). Parvovirus B19 IgG antibody was detected in 244 of 952 patients attending pediatric hematology clinics (25.6%). Parvovirus B19 IgM and IgG positivity in samples from pediatric in-and-outpatient clinics other than pediatric hematology were 2.8% and 35.7%, respectively. Parvovirus IgM and IgG positivity in serum samples sent from the pediatric hematology clinic and outpatients was statistically significant compared with those sent from pediatric clinics other than pediatric hematology (p = 0.0001 and p = 0.0008, respectively). The higher detection rate of serum parvovirus B19 IgM positivity in patients under the follow-up of pediatric hematology clinics suggests that immune suppression-related viral reinfection or persistence may occur in these patients.
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    Late-onset Streptococcus pasteurianus sepsis in a preterm baby in a neonatal intensive care unit
    (Aves, 2014) Tarakci, Nuriye; Dagi, Hatice Turk; Ugur, Ayse Ruveyda; Tuncer, Inci; Tastekin, Ayhan
    Apnea, cyanosis, lethargy and prolongation in capillary filling time developed on the postnatal 37th day in a preterm baby who was born at the 30th gestational week with a birth weight of 1 300 g. Acute phase reactants and immature/total neutrophil count ratio were found to be high. The patient who was diagnosed with sepsis was successfully treated with meropenem which was started empirically. In his blood culture Streptococcus pasteurianus grew. S. pasteurianus is in the subgroup of streptococcus bovis which is one of the D group streptococci and its previous name is S. bovis type II/2. In the literature, there are very few cases of neonatal infection related with this bacterium. As far as we know, this is first case of neonatal sepsis caused by S. pasteurianus in Turkey. In addition, we tried to determine the clinical properties of neonatal infections arising from S. pasteurianus by reviewing the literature.
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    Might miRNAs Be Related to Mother-to-Child Transmission of HIV-1? A Short Review on Putative Viral miRNAs Encoded by HIV-1
    (Georg Thieme Verlag Kg, 2018) Ugur, Ayse Ruveyda; Ozdemir, Mehmet
    MicroRNAs (miRNAs) are single-stranded small noncoding RNA molecules that are 22 to 25 nucleotides in length. They are implicated in the regulation of the immune response by modulating differentiation and proliferation of immune cells, production of cytokine types, and activation of the intracellular signaling pathways through posttranscriptional mechanisms. Although their actual functions are not yet fully understood, viral miRNAs are thought to help viruses to replicate and evade host immune response important in infectiousness. The determinants affecting the infectiousness of human immunodeficiency virus-1 (HIV-1) and progression to the disease state vary according to several host and viral factors. Interestingly, mother-to-child transmission rates are as low as 5 to 15%, even when the mother is not receiving antiretroviral therapy. Higher HIV-1 viral loads, and recent maternal infection, are associated with higher transmission rates. Also, cellular tropism is a well-known phenomenon in HIV-1 pathogenesis. Further, cellular and viral miRNAs seem to be involved in the pathogenesis and infectiousness of HIV-1. The aim of this review is to outline the history of the discovery of HIV-1-viral miRNAs and the evidence for their role in pathogenesis.
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    THE USE OF ACUTE-PHASE PROTEINS APACHE II AND SOFA TO PREDICT THE MORTALITY OF COVID-19 PATIENTS
    (Nobel Ilac, 2023) Deniz, Cigdem Damla; Visneci, Emin Fatih; Eryilmaz, Mehmet Ali; Tutar, Mahmut Sami; Iyisoy, Mehmet Sinan; Ugur, Ayse Ruveyda; Koc, Mehmet
    Objective: Acute-phase proteins are a family of proteins synthesized by the liver. With this study, we aimed to investigate the effects of COVID-19 infection on acute phase reactants (AFR) and determine the usability of AFRs as prognostic factors in COVID-19 disease.Material and Method: Serum samples taken for routine analysis of the patients admitted to the Emergency Department and diagnosed with COVID-19, were used. AFR levels of 30 patients who resulted in mortality and 30 recovered patients were evaluated. C-reactive protein (CRP), ferritin (FER), ceruloplasmin (Cp), albumin (Alb), prealbumin (Prealb), transferrin (Trf), lactate, Acute Physiology and Chronic Health Evaluation (APACHE), and Sequential Organ Failure Assessment (SOFA) assessment was performed.Results: The hazard ratio and 95% confidence interval for FER, CRP, lactate, Alb, Cp, Prealb, Trf, Age, SOFA, and APACHE were 1.001 (1.000-1.001), 1.005 (1.001- 1.008), 1.141 (1.016-1.243), 1.016 (0.740-1.399), 1.016 (0.740-1.399), 1.056 (1.017-1.100), 0.978 (0.917-1.035), 1.000 (0.995-1.006), 1.032 (1.004- 1.064), 1.104 (0.971-1.247), and 1.012 (0.974-1.051), respectively, in univariable model. Only CRP, lactate, and FER found significant in multivariable model. In addition, patients in the nonsurvivors group had significantly higher FER, CRP, lactate, APACHE, age, and SOFA. Nonsurvivors also had lower Alb, Prealb, and serum Trf level compared to survivors.Conclusion: CRP, lactate, and FER, which we have shown to be significantly higher in severe COVID-19 patients, will be valuable parameters that will contribute to clinical improvement if they are used in the follow-up of patients due to their easy measurement and predictive values.