Might miRNAs Be Related to Mother-to-Child Transmission of HIV-1? A Short Review on Putative Viral miRNAs Encoded by HIV-1
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Georg Thieme Verlag Kg
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
MicroRNAs (miRNAs) are single-stranded small noncoding RNA molecules that are 22 to 25 nucleotides in length. They are implicated in the regulation of the immune response by modulating differentiation and proliferation of immune cells, production of cytokine types, and activation of the intracellular signaling pathways through posttranscriptional mechanisms. Although their actual functions are not yet fully understood, viral miRNAs are thought to help viruses to replicate and evade host immune response important in infectiousness. The determinants affecting the infectiousness of human immunodeficiency virus-1 (HIV-1) and progression to the disease state vary according to several host and viral factors. Interestingly, mother-to-child transmission rates are as low as 5 to 15%, even when the mother is not receiving antiretroviral therapy. Higher HIV-1 viral loads, and recent maternal infection, are associated with higher transmission rates. Also, cellular tropism is a well-known phenomenon in HIV-1 pathogenesis. Further, cellular and viral miRNAs seem to be involved in the pathogenesis and infectiousness of HIV-1. The aim of this review is to outline the history of the discovery of HIV-1-viral miRNAs and the evidence for their role in pathogenesis.
Açıklama
Anahtar Kelimeler
Hiv-1, Viral Mirna, Mother-To-Child Transmission, Pathogenesis
Kaynak
Journal Of Pediatric Infectious Diseases
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
13
Sayı
1
