Might miRNAs Be Related to Mother-to-Child Transmission of HIV-1? A Short Review on Putative Viral miRNAs Encoded by HIV-1

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dc.contributor.authorUgur, Ayse Ruveyda
dc.contributor.authorOzdemir, Mehmet
dc.date.accessioned2024-02-23T14:16:52Z
dc.date.available2024-02-23T14:16:52Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractMicroRNAs (miRNAs) are single-stranded small noncoding RNA molecules that are 22 to 25 nucleotides in length. They are implicated in the regulation of the immune response by modulating differentiation and proliferation of immune cells, production of cytokine types, and activation of the intracellular signaling pathways through posttranscriptional mechanisms. Although their actual functions are not yet fully understood, viral miRNAs are thought to help viruses to replicate and evade host immune response important in infectiousness. The determinants affecting the infectiousness of human immunodeficiency virus-1 (HIV-1) and progression to the disease state vary according to several host and viral factors. Interestingly, mother-to-child transmission rates are as low as 5 to 15%, even when the mother is not receiving antiretroviral therapy. Higher HIV-1 viral loads, and recent maternal infection, are associated with higher transmission rates. Also, cellular tropism is a well-known phenomenon in HIV-1 pathogenesis. Further, cellular and viral miRNAs seem to be involved in the pathogenesis and infectiousness of HIV-1. The aim of this review is to outline the history of the discovery of HIV-1-viral miRNAs and the evidence for their role in pathogenesis.en_US
dc.identifier.doi10.1055/s-0037-1612605
dc.identifier.endpage14en_US
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85038405913en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://doi.org/10.1055/s-0037-1612605
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12839
dc.identifier.volume13en_US
dc.identifier.wosWOS:000426303500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal Of Pediatric Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHiv-1en_US
dc.subjectViral Mirnaen_US
dc.subjectMother-To-Child Transmissionen_US
dc.subjectPathogenesisen_US
dc.titleMight miRNAs Be Related to Mother-to-Child Transmission of HIV-1? A Short Review on Putative Viral miRNAs Encoded by HIV-1en_US
dc.typeArticleen_US

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