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    The effect of low dose ionizing radiation exposure on dynamic thiol-disulfide homeostasis and ischemia modified albumin levels: an observational study
    (Elsevier Science Inc, 2020) Arican, Sule; Dertli, Ramazan; Baktik, Suleyman; Hacibeyoglu, Gulcin; Erol, Atilla; Ulukaya, Sinan Oguzhan; Goger, Esra
    Background: The primary objective of this study was to investigate the effect of low dose ionizing radiation exposure on thiol/disulfide homeostasis and ischemia modified albumin levels. The secondary objective is to compare thiol/disulfide homeostasis and ischemia modified albumin levels among the personnel exposed to low dose ionizing radiation in anesthesia application areas, in and out of the Operation room. Methods: The study included a total of 90 volunteers aged between 18 and 65 years old, with 45 personnel working in a setting with potential for radiation exposure (Exposed Group) and 45 personnel in a setting without radiation exposure (Control Group). Their native thiol, total thiol, disulphide, albumine and IMA levels were measured. Exposed group included personnel who were exposed to radiation outside the operating room - Operation room (-) Group and inside the Operating room - Operation room (+) Group. Results: Albumin, native and total thiol levels were significantly lower in the participants exposed to radiation in the anesthesia application area, no statistically significant difference was found in terms of disulfide and ischemia modified albumin levels. In the Operation room (-) group exposed to radiation, native thiol and total thiol values were significantly lower compared to the Operation room (+) groups. Conclusion: Awareness of being in danger of oxidative stress should be established in personnel exposed to radiation in the anesthesia application area following low dose ionizing radiation exposure, and the necessary measures should be taken. (C) 2020 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.
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    Evaluation of the efficacy of erector spinae plane block and intercostal nerve block in the postherpetic neuralgia
    (Kare Publ, 2020) Hacibeyoglu, Gulcin; Arican, Sule; Ulukaya, Sinan Oguzhan; Yilmaz, Resul; Reisli, Ruhiye; Uzun, Sema Tuncer
    Objectives: The aim of this study was to compare the efficacy of an intercostal nerve block, which has been used for many years in the treatment of postherpetic neuralgia, and the more recent alternative of an erector spinae plane (ESP) block. Methods: The records of 39 patients who were treated in the algology department for postherpetic neuralgia between May 1, 2015 and May 1, 2018 were evaluated retrospectively. Patients who received an intercostal nerve block constituted Group 1 and those who received an ESP block were categorized as Group 2. The change in numeric rating scale (NRS) and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scores in the short term and in the long term were the primary results of the study. Results: The NRS, LANSS, and sleep interference scale (SIS) scores of the patients in Group 1 and Group 2 were found to be significantly lower at the 24th hour, week 4, and week 12 compared with the values obtained before block application. In Group 1, the scores recorded at week 4 and week 12 were significantly higher than the 24th hour values, whereas no difference was observed between these results in Group 2.There was no significant difference between the groups in the week 4 and week 12 scores. Similarly, no significant difference was observed in the NRS, LANSS, or SIS scores before the block application or at the 24th hour. However, the scores at week 4 and week 12 were significantly lower in Group 2 compared with Group 1. Conclusion: The results indicated that an ESP block significantly decreased neuropathic pain symptoms and the need for additional treatment in postherpetic neuralgia treatment in the long term.
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    Evaluation of the efficacy of erector spinae plane block and intercostal nerve block in the postherpetic neuralgia
    (Kare Publ, 2020) Hacibeyoglu, Gulcin; Arican, Sule; Ulukaya, Sinan Oguzhan; Yilmaz, Resul; Reisli, Ruhiye; Uzun, Sema Tuncer
    Objectives: The aim of this study was to compare the efficacy of an intercostal nerve block, which has been used for many years in the treatment of postherpetic neuralgia, and the more recent alternative of an erector spinae plane (ESP) block. Methods: The records of 39 patients who were treated in the algology department for postherpetic neuralgia between May 1, 2015 and May 1, 2018 were evaluated retrospectively. Patients who received an intercostal nerve block constituted Group 1 and those who received an ESP block were categorized as Group 2. The change in numeric rating scale (NRS) and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scores in the short term and in the long term were the primary results of the study. Results: The NRS, LANSS, and sleep interference scale (SIS) scores of the patients in Group 1 and Group 2 were found to be significantly lower at the 24th hour, week 4, and week 12 compared with the values obtained before block application. In Group 1, the scores recorded at week 4 and week 12 were significantly higher than the 24th hour values, whereas no difference was observed between these results in Group 2.There was no significant difference between the groups in the week 4 and week 12 scores. Similarly, no significant difference was observed in the NRS, LANSS, or SIS scores before the block application or at the 24th hour. However, the scores at week 4 and week 12 were significantly lower in Group 2 compared with Group 1. Conclusion: The results indicated that an ESP block significantly decreased neuropathic pain symptoms and the need for additional treatment in postherpetic neuralgia treatment in the long term.
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    Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia
    (Walter De Gruyter Gmbh, 2019) Arican, Sule; Hacibeyoglu, Gulcin; Ulukaya, Sinan Oguzhan; Avcioglu, Gamze; Reisli, Ruhiye; Uzun, Sema Tuncer; Erel, Ozcan
    Background: Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods: A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to measure serum IMA levels. Results: Serum IMA levels were 1.21 +/- 0.58 AU and 0.75 +/- 0.09 AU in the PHN and control groups, respectively (p <0.001). Serum total thiol concentrations were found to be 421.62 +/- 90.28 mu mol/L and 598.36 +/- 73.63 mu mol/L in the PHN and control groups, respectively (p <0.001). Serum native thiol concentrations were found to be 365.75 +/- 92.07 mu mol/L and 531.90 +/- 72.9 mu mol/L in the PHN and control groups, respectively (p < 0.001). Serum disulfide concentrations were found to be 33.23 +/- 5.33 mu mol/L and 27.93 +/- 7.81 mu mol/L in the PHN and control groups, respectively (p= 0.003). The native thiol/total thiol ratio was significantly lower, and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the PHN group compared to the controls. Conclusions: IMA levels are high and dynamic thiol/disulfide homeostasis is disrupted in PHN patients.
  • Küçük Resim Yok
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    Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia
    (Walter De Gruyter Gmbh, 2019) Arican, Sule; Hacibeyoglu, Gulcin; Ulukaya, Sinan Oguzhan; Avcioglu, Gamze; Reisli, Ruhiye; Uzun, Sema Tuncer; Erel, Ozcan
    Background: Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods: A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to measure serum IMA levels. Results: Serum IMA levels were 1.21 +/- 0.58 AU and 0.75 +/- 0.09 AU in the PHN and control groups, respectively (p <0.001). Serum total thiol concentrations were found to be 421.62 +/- 90.28 mu mol/L and 598.36 +/- 73.63 mu mol/L in the PHN and control groups, respectively (p <0.001). Serum native thiol concentrations were found to be 365.75 +/- 92.07 mu mol/L and 531.90 +/- 72.9 mu mol/L in the PHN and control groups, respectively (p < 0.001). Serum disulfide concentrations were found to be 33.23 +/- 5.33 mu mol/L and 27.93 +/- 7.81 mu mol/L in the PHN and control groups, respectively (p= 0.003). The native thiol/total thiol ratio was significantly lower, and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the PHN group compared to the controls. Conclusions: IMA levels are high and dynamic thiol/disulfide homeostasis is disrupted in PHN patients.