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  • Küçük Resim
    Öğe
    Determination of fatty acid profiles of total, neutral, and polar lipids in different tissues of Vimba vimba (L., 1758) from Eğirdir Lake (Isparta, Turkey)
    (2013) Güler, Gökalp Özmen; Görgün, Salih; Akpınar, Nükhet; Zengin, Gökhan; Akpınar, Mehmet Ali; Günlü, Ali; Aktümsek, Abdurrahman
    Fatty acid profiles of total, neutral, and polar lipids in the liver, muscle, and intestine of female individuals of Vimba vimba (L., 1758) were determined by gas chromatography. C16:0, C16:1 n-7, C18:1 n-7, and C18:1 n-9 were the most abundant fatty acids in total and neutral lipids in all tissues investigated. In addition to these acids, C20:4 n-6 (arachidonic acid) and C22:6 n-3 (docosahexaenoic acid) were the other fatty acids having high percentages in the polar lipid fraction of the tissues. The highest and lowest n-3 to n-6 ratios, which are a good indicator of the quality of fish oils, were determined in the muscle (1.68) and liver (0.68) in the polar lipid fraction, respectively. It was determined that the species had low levels of the n-3 forms of polyunsaturated fatty acids in the investigated tissues. For a better understanding of fatty acid metabolism of V. vimba, more detailed studies are required in terms of feeding experiments.
  • Küçük Resim
    Öğe
    In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation
    (2018) Uysal, Şengül; Ceylan, Ramazan; Abdurrahman , Aktumsek; Güler, Gökalp Özmen; Picot, Carene; Zengin, Gökhan
    Prevention and treatment of noncommunicable diseases such as neurodegenerative diseases, diabetes, and hyperpigmentationusing medicinal plants has attracted increasing attention during the past few decades. In this study, Colutea cilicicaBoiss. & Balansa extracts (ethyl acetate, methanol, and water) were evaluated against key enzymes involved in neurodegenerativediseases, diabetes, and hyperpigmentation. The antioxidant (free radical scavenging, reducing power, ?-carotene/linoleic acid, and phosphomolybdenum) and metal chelation properties were also investigated. The methanol extracts of C.cilicica vigorously inhibited the activities of acetylcholinesterase and butyrylcholinesterase (1.33 and 0.68 mg galantamineequivalents (GALAE)/g extract, respectively). It was observed that C. cilicica extracts possessed a higher inhibitory potentialfor ?-glucosidase (2.71–1.23 mmol acarbose equivalents (ACAE)/g extract) than that for ?-amylase (0.57–0.12 mmol ACAE/gextract). The water extract of C. cilicica showed potent radical scavenging capacity against DPPH (2, 2-diphenyl-1-picrylhydrazyl)and ABTS (2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (42.46 and 57.70 mg trolox equivalents (TE)/g extract,respectively). Phytochemical determination showed that C. cilicica water extract (17.26 mg rutin equivalents (RE)/g extract)was rich in flavonoids compared with ethyl acetate and methanol extracts (2.78 and 2.83 mg RE/g extract, for the respectiveextracts). These findings reveal the interesting potential of C. cilicica as a valuable source of phytochemicals that can be usedagainst common noncommunicable diseases, particularly against enzymes involved in neurodegenerative diseases.