In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Prevention and treatment of noncommunicable diseases such as neurodegenerative diseases, diabetes, and hyperpigmentationusing medicinal plants has attracted increasing attention during the past few decades. In this study, Colutea cilicicaBoiss. & Balansa extracts (ethyl acetate, methanol, and water) were evaluated against key enzymes involved in neurodegenerativediseases, diabetes, and hyperpigmentation. The antioxidant (free radical scavenging, reducing power, ?-carotene/linoleic acid, and phosphomolybdenum) and metal chelation properties were also investigated. The methanol extracts of C.cilicica vigorously inhibited the activities of acetylcholinesterase and butyrylcholinesterase (1.33 and 0.68 mg galantamineequivalents (GALAE)/g extract, respectively). It was observed that C. cilicica extracts possessed a higher inhibitory potentialfor ?-glucosidase (2.71–1.23 mmol acarbose equivalents (ACAE)/g extract) than that for ?-amylase (0.57–0.12 mmol ACAE/gextract). The water extract of C. cilicica showed potent radical scavenging capacity against DPPH (2, 2-diphenyl-1-picrylhydrazyl)and ABTS (2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (42.46 and 57.70 mg trolox equivalents (TE)/g extract,respectively). Phytochemical determination showed that C. cilicica water extract (17.26 mg rutin equivalents (RE)/g extract)was rich in flavonoids compared with ethyl acetate and methanol extracts (2.78 and 2.83 mg RE/g extract, for the respectiveextracts). These findings reveal the interesting potential of C. cilicica as a valuable source of phytochemicals that can be usedagainst common noncommunicable diseases, particularly against enzymes involved in neurodegenerative diseases.
Açıklama
WOS:000433052800004
Anahtar Kelimeler
Colutea cilica, Alzheimer’s disease, d-Diabetes mellitus, Natural agents, Phytopharmaceuticals
Kaynak
Istanbul Journal of Pharmacy
WoS Q Değeri
Scopus Q Değeri
Cilt
48
Sayı
1
Künye
Uysal, Ş., Ceylan, R., Aktümsek, A., Güler, G. Ö., Picot, C., Zengin, G., Mahomoodally, M. F. (2018). In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. Istanbul Journal of Pharmacy, 48, 1, 18-22.
Bağlantı
https://dx.doi.org/10.5152/IstanbulJPharm.2018.396764
https://app.trdizin.gov.tr/makale/TXpFd05qUXdNQT09/in-vitro-multiple-pharmacological-targets-of-colutea-cilicica-boiss-balansa-against-key-enzymes-linked-to-neurodegenerative-diseases-diabetes-and-hyperpigmentation
https://hdl.handle.net/20.500.12452/2848
https://app.trdizin.gov.tr/makale/TXpFd05qUXdNQT09/in-vitro-multiple-pharmacological-targets-of-colutea-cilicica-boiss-balansa-against-key-enzymes-linked-to-neurodegenerative-diseases-diabetes-and-hyperpigmentation
https://hdl.handle.net/20.500.12452/2848
