In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation

Basit Öğe Kaydı
dc.authoridGökalp Özmen Güler: 0000-0003-4771-2489en_US
dc.authoridGökhan Zengin: 0000-0001-6548-7823en_US
dc.contributor.authorUysal, Şengül
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorAbdurrahman , Aktumsek
dc.contributor.authorGüler, Gökalp Özmen
dc.contributor.authorPicot, Carene
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-01-18T21:12:45Z
dc.date.available2020-01-18T21:12:45Z
dc.date.issued2018
dc.departmentNEÜ, Ahmet Keleşoğlu Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümüen_US
dc.descriptionWOS:000433052800004en_US
dc.description.abstractPrevention and treatment of noncommunicable diseases such as neurodegenerative diseases, diabetes, and hyperpigmentationusing medicinal plants has attracted increasing attention during the past few decades. In this study, Colutea cilicicaBoiss. & Balansa extracts (ethyl acetate, methanol, and water) were evaluated against key enzymes involved in neurodegenerativediseases, diabetes, and hyperpigmentation. The antioxidant (free radical scavenging, reducing power, ?-carotene/linoleic acid, and phosphomolybdenum) and metal chelation properties were also investigated. The methanol extracts of C.cilicica vigorously inhibited the activities of acetylcholinesterase and butyrylcholinesterase (1.33 and 0.68 mg galantamineequivalents (GALAE)/g extract, respectively). It was observed that C. cilicica extracts possessed a higher inhibitory potentialfor ?-glucosidase (2.71–1.23 mmol acarbose equivalents (ACAE)/g extract) than that for ?-amylase (0.57–0.12 mmol ACAE/gextract). The water extract of C. cilicica showed potent radical scavenging capacity against DPPH (2, 2-diphenyl-1-picrylhydrazyl)and ABTS (2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (42.46 and 57.70 mg trolox equivalents (TE)/g extract,respectively). Phytochemical determination showed that C. cilicica water extract (17.26 mg rutin equivalents (RE)/g extract)was rich in flavonoids compared with ethyl acetate and methanol extracts (2.78 and 2.83 mg RE/g extract, for the respectiveextracts). These findings reveal the interesting potential of C. cilicica as a valuable source of phytochemicals that can be usedagainst common noncommunicable diseases, particularly against enzymes involved in neurodegenerative diseases.en_US
dc.identifier.citationUysal, Ş., Ceylan, R., Aktümsek, A., Güler, G. Ö., Picot, C., Zengin, G., Mahomoodally, M. F. (2018). In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. Istanbul Journal of Pharmacy, 48, 1, 18-22.en_US
dc.identifier.doi10.5152/IstanbulJPharm.2018.396764en_US
dc.identifier.endpage24en_US
dc.identifier.issn2548-0731en_US
dc.identifier.issn2587-2087en_US
dc.identifier.issue1en_US
dc.identifier.startpage18en_US
dc.identifier.urihttps://dx.doi.org/10.5152/IstanbulJPharm.2018.396764
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpFd05qUXdNQT09/in-vitro-multiple-pharmacological-targets-of-colutea-cilicica-boiss-balansa-against-key-enzymes-linked-to-neurodegenerative-diseases-diabetes-and-hyperpigmentation
dc.identifier.urihttps://hdl.handle.net/20.500.12452/2848
dc.identifier.volume48en_US
dc.identifier.wosWOS:000433052800004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColutea cilicaen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectd-Diabetes mellitusen_US
dc.subjectNatural agentsen_US
dc.subjectPhytopharmaceuticalsen_US
dc.titleIn vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentationen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Akef.pdf
Boyut:
154.61 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu