The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines

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dc.contributor.authorArikoglu, Hilal
dc.contributor.authorDursunoglu, Duygu
dc.contributor.authorKaya, Dudu Erkoc
dc.contributor.authorAvci, Ebru
dc.date.accessioned2024-02-23T14:38:23Z
dc.date.available2024-02-23T14:38:23Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground: Pancreatic cancer does not show any symptoms in the early period and metastatic process is already passed when the diagnosis is done. Therefore, in the battle with pancreatic cancer, novel treatment strategies, particularly antiinva-sive and antimetastatic strategies, are needed. The cytotoxic and anticancer effects of juglone and sodium selenite (NaSe) have been showed in various cancer cells. Objectives: In this study, it is aimed to investigate the synergistic effects of juglone and selenium on PANC-1 and BxPC-3 pancreatic cancer cells. Methods: Antimetastatic effects of juglone-NaSe were carried out by adhesion and invasion assays and the genes and pro-tein expressions. Expression analysis of the CDH1, ITGB3 and COL4A3 genes and their proteins E-cadherin, beta 3 integrin and tumstatin which play role in metastasis and angiogenesis processes, were done by qPCR and immunohistochemical analysis, respectively. Results: Study findings have provided evidences that the juglone-selenium has a cytotoxic and dose dependent suppressive effect on invasion and metastasis in PANC-1 and BxPC-3 cells. Conclusion: The juglone-NaSe has the potential to be a promising agent especially to inhibit invasion and metastasis in pan-creatic cancer treatment. However, more in depth studies are needed to more clearly demonstrate the effects of juglone-se-lenium.en_US
dc.description.sponsorshipSelcuk University Research Foundation [14401090]en_US
dc.description.sponsorshipWe would like to thank to MSc.Aycan Asik for her assistance in this study. This study was supported by the Selcuk University Research Foundation (14401090) .en_US
dc.identifier.doi10.4314/ahs.v22i2.37
dc.identifier.endpage342en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue2en_US
dc.identifier.pmid36407358en_US
dc.identifier.scopus2-s2.0-85135330762en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage334en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v22i2.37
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16508
dc.identifier.volume22en_US
dc.identifier.wosWOS:000837255900037en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMakerere Univ, Coll Health Sciences,Sch Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPancreatic Cancer Cell Linesen_US
dc.subjectJuglone-Seleniumen_US
dc.subjectInvasionen_US
dc.subjectMetastasisen_US
dc.titleThe effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell linesen_US
dc.typeArticleen_US

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