Yenidoğan yoğun bakım ünitesinde izlenen bebeklerde konjenital malformasyon sıklığı
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Tarih
2023
Yazarlar
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Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Konjenital malformasyon veya doğum kusuru, doğumda mevcut olan, genetik olarak kalıtsal olabilen, gebelik sırasında edinilmiş veya doğumdan kaynaklanan yapısal veya işlevsel herhangi bir anormallik olarak tanımlanır. Konjenital malformasyonlar yenidoğan ve çocukluk çağı ölümlerinin, kronik hastalıkların ve morbiditenin en önemli nedenlerinden birini oluşturmaktadır. Bu çalışmanın amacı Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Hastanesi yenidoğan yoğun bakım ünitesinde yatarak tedavi gören olgularda konjenital malformasyonları tanımlamak, sıklığını saptamak ve etiyolojide etkili olabilecek faktörleri araştırmaktır. 1 Ekim 2017 – 15 Ekim 2021 tarihleri arasında yenidoğan yoğun bakım ünitesinde yatan 4860 hastanın dosyaları retrospektif olarak incelendi. Bu vakalar arasında malformasyon sıklığı %8.7 olarak saptandı. Organ sistemlerine göre malformasyonların dağılımına bakıldığında en sık etkilenen sistem kardiyovasküler sistemdi (%23,8). Bunu sırayla santral sinir sistemi (%21,6), genitoüriner sistem (%17,7), gastrointestinal sistem (%12,5), baş-boyun-yüz (%11,5), kas-iskelet (%7) ve solunum sistemi (%6) anomalileri izledi. En sık saptanan izole anomali ise hidronefrozdu (%11,5). Çalışma kapsamına giren olgularda ayrıca; cinsiyet, anne-baba akrabalık durumu, anne yaşı, antenatal tanı alıp almadığı, gebelik haftası, doğum ağırlığı, doğum şekli, fetüs sayısı, gebelik sayısı, eşlik eden sendromlar, maternal hastalıklar, maternal ilaç, sigara ve madde kullanımı, gebelik öncesi ve gebelikte folik asit replasmanı, önceki gebeliklerde düşük, malformasyon ve ölüm hikayesi, malformasyonlu bebeklerdeki ölüm oranı, malformasyonun tipi, tekli/çoklu oluşu araştırıldı, bu parametreler arasındaki ilişki arandı. Çalışma sonucunda, idrar yolu enfeksiyonu geçiren gebelerin bebeklerinde GÜS malformasyonları ve Covid-19 enfeksiyonu geçiren gebelerin bebeklerinde santral sinir sistemi malformasyonlarının görülmesi göze çarpmaktaydı. Ayrıca preterm bebeklerde kardiyovasküler ve gastrointestinal sistem anomalilerinin ortaya çıkması ve solunum sistemi
iv
malformasyonlarının ise yüksek oranda ölümle sonuçlanması diğer öne çıkan bulgular arasındaydı. Genel olarak konjenital malformasyon sıklığının belirlenmesi ve etiyolojide etkili olabilecek faktörlerin saptanıp buna göre önlemler alınması gerek morbidite ve mortalitenin azalmasında gerekse toplumların sosyoekonomik refahının artmasında önemli bir rol oynayacaktır.
A congenital malformation or birth defect is defined as any structural or functional abnormality that is present at birth, may be genetically inherited, acquired during pregnancy, or resulting from birth. Congenital malformations constitute one of the most important causes of newborn and childhood deaths, chronic diseases and morbidity. The aim of this study is to define congenital malformations, to determine the frequency and to investigate the factors that may be effective in the etiology in inpatients in the Newborn Intensive Care Unit of Necmettin Erbakan University Meram Medical Faculty Hospital. The files of 4860 patients hospitalized in the newborn intensive care unit between October 1, 2017 and October 15, 2021 were reviewed retrospectively. Among these cases, the frequency of malformation was found to be 8.7%. Considering the distribution of malformations by organ systems, the most frequently affected system was the cardiovascular system (23.8%). This is followed by central nervous system (21.6%), genitourinary system (17.7%), gastrointestinal system (12.5%), head-neck-face (11.5%), musculoskeletal (7%) and respiratory system (6%) anomalies followed. The most common type of isolated anomaly was hydronephrosis (11.5%). In addition, in the cases included in the study; gender, parental consanguinity, maternal age, prenatal follow-up status, antenatal diagnosis, week of gestation, birth weight, mode of delivery, number of fetuses, parity number, concomitant syndromes, maternal diseases, maternal drug, smoking and substance use, Folic acid replacement before and during pregnancy, history of miscarriage, malformation and death in previous pregnancies, mortality rate in babies with malformations, type of malformation, single/multiple occurrence were investigated, and the relationship between these parameters was searched. As a result of the study, genitourinary system malformations were observed in the babies of pregnant women who had urinary tract infection, and central nervous system malformations were observed in babies of pregnant women who had Covid-19 infection. In vi addition, the emergence of cardiovascular and gastrointestinal system anomalies in preterm infants and the high rate of death of respiratory system malformations were among the other prominent findings. In general, determining the frequency of congenital malformations and determining the factors that may be effective in the etiology and taking measures accordingly will play an important role in both reducing morbidity and mortality and increasing the socio-economic well-being of societies.
A congenital malformation or birth defect is defined as any structural or functional abnormality that is present at birth, may be genetically inherited, acquired during pregnancy, or resulting from birth. Congenital malformations constitute one of the most important causes of newborn and childhood deaths, chronic diseases and morbidity. The aim of this study is to define congenital malformations, to determine the frequency and to investigate the factors that may be effective in the etiology in inpatients in the Newborn Intensive Care Unit of Necmettin Erbakan University Meram Medical Faculty Hospital. The files of 4860 patients hospitalized in the newborn intensive care unit between October 1, 2017 and October 15, 2021 were reviewed retrospectively. Among these cases, the frequency of malformation was found to be 8.7%. Considering the distribution of malformations by organ systems, the most frequently affected system was the cardiovascular system (23.8%). This is followed by central nervous system (21.6%), genitourinary system (17.7%), gastrointestinal system (12.5%), head-neck-face (11.5%), musculoskeletal (7%) and respiratory system (6%) anomalies followed. The most common type of isolated anomaly was hydronephrosis (11.5%). In addition, in the cases included in the study; gender, parental consanguinity, maternal age, prenatal follow-up status, antenatal diagnosis, week of gestation, birth weight, mode of delivery, number of fetuses, parity number, concomitant syndromes, maternal diseases, maternal drug, smoking and substance use, Folic acid replacement before and during pregnancy, history of miscarriage, malformation and death in previous pregnancies, mortality rate in babies with malformations, type of malformation, single/multiple occurrence were investigated, and the relationship between these parameters was searched. As a result of the study, genitourinary system malformations were observed in the babies of pregnant women who had urinary tract infection, and central nervous system malformations were observed in babies of pregnant women who had Covid-19 infection. In vi addition, the emergence of cardiovascular and gastrointestinal system anomalies in preterm infants and the high rate of death of respiratory system malformations were among the other prominent findings. In general, determining the frequency of congenital malformations and determining the factors that may be effective in the etiology and taking measures accordingly will play an important role in both reducing morbidity and mortality and increasing the socio-economic well-being of societies.
Açıklama
Anahtar Kelimeler
Anomali, Konjenital malformasyon, Etiyoloji, Sıklık, Anomaly, Congenital malformation, Etiology, Frequency
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Emiroğlu, N. (2023). Yenidoğan yoğun bakım ünitesinde izlenen bebeklerde konjenital malformasyon sıklığı. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Dahili Tıp Bilimleri Bölümü Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Konya.
