Six-month outcomes of corneal crosslinking with dextran-free isotonic riboflavin solution
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Consel Brasil Oftalmologia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To analyze the short-term clinical and topographic outcomes in patients with keratoconus after corneal collagen cross-linking treatment (CXL) with dextran-free isotonic riboflavin solution. Methods: In this retrospective case series, 26 eyes from 26 patients with keratoconus were studied. The best corrected visual acuity (BCVA) and refractive and topographic findings were analyzed at a 6-month follow-up. Results: The mean BCVA (Snellen lines) values before and 1, 3, and 6 months after CXL were 0.51 +/- 0.2, 0.48 +/- 0.2, 0.57 +/- 0.2, and 0.64 +/- 0.2, respectively, and the difference between the preoperative and 6-month values was statistically significant (p=0.006). The mean spherical equivalent refraction decreased from -5.6 +/- 2.4 diopters (D) preoperatively to -5.0 +/- 2.1 D, and mean simulated keratometry decreased from 48.5 +/- 2.5 D to 47.8 +/- 2.6 D at 6 months. (p=0.145 and p=0.001, respectively). In addition, the maximum keratometry decreased progressively and significantly from the preoperative value during follow-up (p=0.003). The central and minimal corneal thicknesses, including those of the epithelium, also decreased from 442.8 +/- 25.6 mu m and 430.5 +/- 23.9 mu m preoperatively to 420.7 +/- 31.8 mu m and 409.3 +/- 28.7 mu m at the most recent follow-up (p<0.001), respectively. No intraoperative or postoperative complications were observed. Conclusions: CXL with dextran-free isotonic riboflavin solution appears to be a safe treatment alternative for keratoconus and yields sustained short-term improvements in visual acuity, keratometric readings, and corneal thickness. However, long-term results are needed to confirm these outcomes.
Açıklama
Anahtar Kelimeler
Cornea, Collagen, Cross-Linking Reagents, Riboflavin/Therapeutic Use, Ultraviolet Rays, Dextrans, Visual Acuity
Kaynak
Arquivos Brasileiros De Oftalmologia
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
79
Sayı
3
