Six-month outcomes of corneal crosslinking with dextran-free isotonic riboflavin solution

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dc.contributor.authorOltulu, Refik
dc.contributor.authorSatirtav, Gunhal
dc.contributor.authorDonbaloglu, Meryem
dc.contributor.authorGunduz, Mehmet Kemal
dc.contributor.authorLu, Hurkan Kerimog
dc.contributor.authorOkka, Mehmet
dc.contributor.authorOzkagnici, Ahmet
dc.date.accessioned2024-02-23T14:44:47Z
dc.date.available2024-02-23T14:44:47Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractPurpose: To analyze the short-term clinical and topographic outcomes in patients with keratoconus after corneal collagen cross-linking treatment (CXL) with dextran-free isotonic riboflavin solution. Methods: In this retrospective case series, 26 eyes from 26 patients with keratoconus were studied. The best corrected visual acuity (BCVA) and refractive and topographic findings were analyzed at a 6-month follow-up. Results: The mean BCVA (Snellen lines) values before and 1, 3, and 6 months after CXL were 0.51 +/- 0.2, 0.48 +/- 0.2, 0.57 +/- 0.2, and 0.64 +/- 0.2, respectively, and the difference between the preoperative and 6-month values was statistically significant (p=0.006). The mean spherical equivalent refraction decreased from -5.6 +/- 2.4 diopters (D) preoperatively to -5.0 +/- 2.1 D, and mean simulated keratometry decreased from 48.5 +/- 2.5 D to 47.8 +/- 2.6 D at 6 months. (p=0.145 and p=0.001, respectively). In addition, the maximum keratometry decreased progressively and significantly from the preoperative value during follow-up (p=0.003). The central and minimal corneal thicknesses, including those of the epithelium, also decreased from 442.8 +/- 25.6 mu m and 430.5 +/- 23.9 mu m preoperatively to 420.7 +/- 31.8 mu m and 409.3 +/- 28.7 mu m at the most recent follow-up (p<0.001), respectively. No intraoperative or postoperative complications were observed. Conclusions: CXL with dextran-free isotonic riboflavin solution appears to be a safe treatment alternative for keratoconus and yields sustained short-term improvements in visual acuity, keratometric readings, and corneal thickness. However, long-term results are needed to confirm these outcomes.en_US
dc.identifier.doi10.5935/0004-2749.20160045
dc.identifier.endpage150en_US
dc.identifier.issn0004-2749
dc.identifier.issn1678-2925
dc.identifier.issue3en_US
dc.identifier.pmid27463623en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage147en_US
dc.identifier.urihttps://doi.org/10.5935/0004-2749.20160045
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17112
dc.identifier.volume79en_US
dc.identifier.wosWOS:000380804900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherConsel Brasil Oftalmologiaen_US
dc.relation.ispartofArquivos Brasileiros De Oftalmologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCorneaen_US
dc.subjectCollagenen_US
dc.subjectCross-Linking Reagentsen_US
dc.subjectRiboflavin/Therapeutic Useen_US
dc.subjectUltraviolet Raysen_US
dc.subjectDextransen_US
dc.subjectVisual Acuityen_US
dc.titleSix-month outcomes of corneal crosslinking with dextran-free isotonic riboflavin solutionen_US
dc.typeArticleen_US

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