Effect of cigarette smoking on serum methylarginine and a-klotho levels
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and aims: Smoking causes many diseases such as cardiovascular, lung dis-eases, stroke and premature aging. However, the role of smoking in the pathogenesis of these diseases is unclear. Increasing evidence suggests that methylarginine pathway metabolites and a-klotho may be strong markers for pathologies such as premature aging, endothelial dysfunc-tion, and oxidant damage. Therefore, the study aimed to measure the serum levels of arginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), N-monomethyl-L- arginine (L-NMMA), and a-klotho levels in smokers. Methods and results: This case-control analytical study included 65 smokers and 71 non-smokers. Sociodemographic characteristics, routine biochemistry parameters, Framingham risk scores and Fagerstrom Nicotine Dependence Test (FTND) were recorded. Serum methylarginine and a-klotho levels were analyzed by tandem mass spectrometry and enzyme-linked immunosorbent assay (ELISA), respectively. Serum ADMA (p < 0.001), L-NMMA (p Z 0.024), SDMA (p < 0.001) levels of smokers were higher than non-smokers, and serum a-klotho (p < 0.001) and arginine levels (p < 0.001) were lower. There was a positive correlation between serum ADMA levels with FNDT, age and pack/year in smokers, while there was a negative correlation between klotho levels and age. A positive correlation was found between serum ADMA levels, Framingham risk score and age in non-smokers. Conclusion: Smoking is related to premature aging and is a strong risk factor for various diseases such as cardiovascular, inflammatory, and renal diseases. Elevated serum methylarginine and decreased serum klotho levels were found in smokers. Therefore, our findings suggest that smok-ing may be involved in the pathogenesis of these diseases by affecting a-klotho and methylarginine-related pathways. (c) 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Ital-ian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Smoking, Adma, Arginine, Methylarginine, A-Klotho, Aging
Kaynak
Nutrition Metabolism And Cardiovascular Diseases
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
33
Sayı
3
