Effect of cigarette smoking on serum methylarginine and a-klotho levels

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dc.contributor.authorOnmaz, Mustafa
dc.contributor.authorDemirbas, Nur
dc.contributor.authorOnmaz, Duygu Eryavuz
dc.contributor.authorKutlu, Ruhusen
dc.contributor.authorUnlu, Ali
dc.date.accessioned2024-02-23T14:13:20Z
dc.date.available2024-02-23T14:13:20Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground and aims: Smoking causes many diseases such as cardiovascular, lung dis-eases, stroke and premature aging. However, the role of smoking in the pathogenesis of these diseases is unclear. Increasing evidence suggests that methylarginine pathway metabolites and a-klotho may be strong markers for pathologies such as premature aging, endothelial dysfunc-tion, and oxidant damage. Therefore, the study aimed to measure the serum levels of arginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), N-monomethyl-L- arginine (L-NMMA), and a-klotho levels in smokers. Methods and results: This case-control analytical study included 65 smokers and 71 non-smokers. Sociodemographic characteristics, routine biochemistry parameters, Framingham risk scores and Fagerstrom Nicotine Dependence Test (FTND) were recorded. Serum methylarginine and a-klotho levels were analyzed by tandem mass spectrometry and enzyme-linked immunosorbent assay (ELISA), respectively. Serum ADMA (p < 0.001), L-NMMA (p Z 0.024), SDMA (p < 0.001) levels of smokers were higher than non-smokers, and serum a-klotho (p < 0.001) and arginine levels (p < 0.001) were lower. There was a positive correlation between serum ADMA levels with FNDT, age and pack/year in smokers, while there was a negative correlation between klotho levels and age. A positive correlation was found between serum ADMA levels, Framingham risk score and age in non-smokers. Conclusion: Smoking is related to premature aging and is a strong risk factor for various diseases such as cardiovascular, inflammatory, and renal diseases. Elevated serum methylarginine and decreased serum klotho levels were found in smokers. Therefore, our findings suggest that smok-ing may be involved in the pathogenesis of these diseases by affecting a-klotho and methylarginine-related pathways. (c) 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Ital-ian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Necmettin Erbakan University [211518007]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinatorship of Necmettin Erbakan University (Project number 211518007) . The authors would like to thank the Necmettin Erbakan University for this study.en_US
dc.identifier.doi10.1016/j.numecd.2022.12.020
dc.identifier.endpage609en_US
dc.identifier.issn0939-4753
dc.identifier.issn1590-3729
dc.identifier.issue3en_US
dc.identifier.pmid36710115en_US
dc.identifier.scopus2-s2.0-85148479624en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage602en_US
dc.identifier.urihttps://doi.org/10.1016/j.numecd.2022.12.020
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12398
dc.identifier.volume33en_US
dc.identifier.wosWOS:001010871100001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofNutrition Metabolism And Cardiovascular Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSmokingen_US
dc.subjectAdmaen_US
dc.subjectArginineen_US
dc.subjectMethylarginineen_US
dc.subjectA-Klothoen_US
dc.subjectAgingen_US
dc.titleEffect of cigarette smoking on serum methylarginine and a-klotho levelsen_US
dc.typeArticleen_US

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