Serum Tenascin-C: A Novel Biomarker for Diagnosis and Predicting Prognosis of Rheumatic Carditis?
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Oxford Univ Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To evaluate the serum TnC level in acute rheumatic fever (ARF) and chronic rheumatic heart disease (CRHD) during childhood. Methods: Twenty-five patients with ARF, 25 patients with CRHD and 20 control subjects were included in the study. The TnC levels were analyzed using the enzyme-linked immunosorbent assay method in the ARF group. Results: The TnC levels were lower in the acute carditis group compared with the control group (p < 0.001). The cut-off level was estimated as 2.08 ng/ml for diagnosing carditis with 93.3% sensitivity and 95% specificity. On second analysis, prominent decrease was detected in valve insufficiency patients with markedly elevated TnC levels. In the CRHD group, TnC level was significantly lower in cases with severe valve insufficiency (p < 0.001). Conclusions: Serum TnC level can be used as a new biochemical marker for diagnosis and predicting the prognosis of rheumatic carditis.
Açıklama
Anahtar Kelimeler
Acute Rheumatic Fever, Children, Chronic Rheumatic Heart Disease, Tenascin-C
Kaynak
Journal Of Tropical Pediatrics
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
59
Sayı
6
