Serum Tenascin-C: A Novel Biomarker for Diagnosis and Predicting Prognosis of Rheumatic Carditis?

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dc.contributor.authorKaratas, Zehra
dc.contributor.authorBaysal, Tamer
dc.contributor.authorAlp, Hayrullah
dc.contributor.authorToker, Aysun
dc.date.accessioned2024-02-23T14:21:03Z
dc.date.available2024-02-23T14:21:03Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractObjective: To evaluate the serum TnC level in acute rheumatic fever (ARF) and chronic rheumatic heart disease (CRHD) during childhood. Methods: Twenty-five patients with ARF, 25 patients with CRHD and 20 control subjects were included in the study. The TnC levels were analyzed using the enzyme-linked immunosorbent assay method in the ARF group. Results: The TnC levels were lower in the acute carditis group compared with the control group (p < 0.001). The cut-off level was estimated as 2.08 ng/ml for diagnosing carditis with 93.3% sensitivity and 95% specificity. On second analysis, prominent decrease was detected in valve insufficiency patients with markedly elevated TnC levels. In the CRHD group, TnC level was significantly lower in cases with severe valve insufficiency (p < 0.001). Conclusions: Serum TnC level can be used as a new biochemical marker for diagnosis and predicting the prognosis of rheumatic carditis.en_US
dc.description.sponsorshipSelcuk University, Meram Medical Faculty Scientific Study Research Commission [2011/71]en_US
dc.description.sponsorshipThis study was financially endorsed by Selcuk University, Meram Medical Faculty Scientific Study Research Commission (registration number 2011/71).en_US
dc.identifier.doi10.1093/tropej/fmt058
dc.identifier.endpage482en_US
dc.identifier.issn0142-6338
dc.identifier.issn1465-3664
dc.identifier.issue6en_US
dc.identifier.pmid23868575en_US
dc.identifier.scopus2-s2.0-84889015963en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage476en_US
dc.identifier.urihttps://doi.org/10.1093/tropej/fmt058
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13432
dc.identifier.volume59en_US
dc.identifier.wosWOS:000328055600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal Of Tropical Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Rheumatic Feveren_US
dc.subjectChildrenen_US
dc.subjectChronic Rheumatic Heart Diseaseen_US
dc.subjectTenascin-Cen_US
dc.titleSerum Tenascin-C: A Novel Biomarker for Diagnosis and Predicting Prognosis of Rheumatic Carditis?en_US
dc.typeArticleen_US

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