Bazı Schiff Bazı-Tiyazol Türevlerinin Sentezi, Antimikrobiyal ve Antioksidan Özelliklerinin İncelenmesi
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Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Necmettin Erbakan Üniversitesi Fen Bilimleri Enstitüsü
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada beş farklı aldehit türevi (3,5-dikloro-2-hidroksibenzaldehit, 3,5-dibromo-2-
hidroksibenzaldehit, 5-bromo-2-hidroksibenzaldehit, 5-kloro-2-hidroksibenzaldehit, 2,3-dihidroksi benzaldehit) tiyosemikarbazit ile asidik ortamda tepkimeye sokularak beş farklı Schiff bazı türevleri elde
edilmiştir. Elde edilen Schiff bazı türevleri, 2,4‟-dibromoasetofenon ve 2-bromo-4‟-nitroasetofenon
bileşikleriyle ayrı ayrı tepkimeye sokularak yeni tiyazol türevleri sentezlenmiştir. Sentezlenen Schiff
bazı-tiyazol türevlerinin yapı tayini FT-IR, 1H NMR ve 13C NMR spektroskopi teknikleri ile karakterize
edilmiştir. Sentezlenen Schiff bazı-tiyazol türevlerinin antimikrobiyal ve antioksidan aktivite çalışmaları
gerçekleştirilmiştir.
In this study, five different Schiff base derivatives were obtained by reacting five different aldehyde derivatives (3,5-dichloro-2-hydroxybenzaldehyde, 3,5-dibromo-2-hydroxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde, 5-chloro-2-hydroxybenzaldehyde, 2,3-dihydroxybenzaldehyde) with thiosemicarbazide in acidic media. New thiazole derivatives were synthesized by reacting the obtained Schiff base derivatives with 2,4'-dibromoacetophenone and 2-bromo-4'-nitroacetophenone compounds separately. Structure determination of synthesized Schiff base and thiazole derivatives were characterized by FT-IR, 1H NMR and 13C NMR spectroscopic techniques. Antimicrobial and antioxidant activity studies of synthesized Schiff base and thiazole derivatives were carried out.
In this study, five different Schiff base derivatives were obtained by reacting five different aldehyde derivatives (3,5-dichloro-2-hydroxybenzaldehyde, 3,5-dibromo-2-hydroxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde, 5-chloro-2-hydroxybenzaldehyde, 2,3-dihydroxybenzaldehyde) with thiosemicarbazide in acidic media. New thiazole derivatives were synthesized by reacting the obtained Schiff base derivatives with 2,4'-dibromoacetophenone and 2-bromo-4'-nitroacetophenone compounds separately. Structure determination of synthesized Schiff base and thiazole derivatives were characterized by FT-IR, 1H NMR and 13C NMR spectroscopic techniques. Antimicrobial and antioxidant activity studies of synthesized Schiff base and thiazole derivatives were carried out.
Açıklama
Yüksek Lisans Tezi
Anahtar Kelimeler
Antioksidan, Antimikrobiyal, Schiff bazı, Tiyazol, Tiyosemikarbazit, Antioxidant, Antimicrobial, Schiff bases, Thiazole, Thiosemicarbazide
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Cenik, Y. (2022). Bazı schiff bazı-tiyazol türevlerinin sentezi, antimikrobiyal ve antioksidan özelliklerinin incelenmesi. (Yayınlanmamış yüksek lisans tezi). Necmettin Erbakan Üniversitesi, Fen Bilimleri Enstitüsü, Kimya Anabilim Dalı, Konya.
