Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells

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dc.contributor.authorKuccukturk, Serkan
dc.contributor.authorKaraselek, Mehmet Ali
dc.contributor.authorDuran, Tugce
dc.contributor.authorKursunlu, Ahmed Nuri
dc.contributor.authorOzmen, Mustafa
dc.date.accessioned2024-02-23T13:43:51Z
dc.date.available2024-02-23T13:43:51Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPurposeThis study was conducted to investigate impacts of potential anticancer (associated with apoptosis and caspase pathways) of two newly synthesized derivatives of pillar[5]arene, named as d-Q-P5 and p-Q-P5, on Squamous cell carcinomas of the head and neck (HNSCC) cells.Materials and methodsThe MTT method was used to determine the IC50 doses of the derivatives on HNSCC cells, and the changes in gene expression were analyzed by real-time polymerase chain reaction (qPCR). The apoptosis change was confirmed by flow cytometry analysis.ResultsThe results showed that the d-Q-P5 and p-Q-P5 effectively inhibited the proliferation of the cells by upregulating proapoptotic genes (Bax, Bad, p53, Bak, and Apaf-1) and genes involved in the caspase pathway (Casp2, Casp3, and Casp9), while downregulating the antiapoptotic gene (Bcl-2).ConclusionsThis study is the first to demonstrate the potential anticancer effects of these two agents on HNSCC cells by positively regulating apoptosis gene expression.en_US
dc.description.sponsorshipNecmettin Erbakan University [221218015]en_US
dc.description.sponsorshipThe study was supported by Necmettin Erbakan University (Project Number: 221218015)en_US
dc.identifier.doi10.1007/s00432-023-04822-y
dc.identifier.endpage8718en_US
dc.identifier.issn0171-5216
dc.identifier.issn1432-1335
dc.identifier.issue11en_US
dc.identifier.pmid37126106en_US
dc.identifier.scopus2-s2.0-85156091861en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage8711en_US
dc.identifier.urihttps://doi.org/10.1007/s00432-023-04822-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10952
dc.identifier.volume149en_US
dc.identifier.wosWOS:000979964000002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Cancer Research And Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHead And Neck Squamous Cell Carcinomaen_US
dc.subjectPillar[5]Areneen_US
dc.subjectApoptosisen_US
dc.subjectCaspaseen_US
dc.titleImpacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cellsen_US
dc.typeArticleen_US

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