A rapid responsive coumarin-naphthalene derivative for the detection of cyanide ions in cell culture

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dc.contributor.authorAydin, Ziya
dc.contributor.authorKeskinates, Mukaddes
dc.contributor.authorYilmaz, Bahar
dc.contributor.authorDurmaz, Mustafa
dc.contributor.authorBayrakci, Mevlut
dc.date.accessioned2024-02-23T14:00:16Z
dc.date.available2024-02-23T14:00:16Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractCyanide ion (CN-) is widely used in many industrial processes; however, it causes several diseases in humans. Therefore, rapid and accurate detection of CN- is very important and urgent. In this study, a CN- sensor (MH-2) which was capable of detecting CN- ions in living cell was developed. MH-2 gives a rapid color change, absorbance and fluorescence response to CN- in the presence of the anions tested in the working system. The binding ratio between the sensor and CN- was demonstrated by some spectrophotometric methods and the sensing mechanism was investigated by NMR titration experiments, suggesting that MH-2 gives response to CN- via the nucleophilic addition reaction. The fluorescence detection limit and the absorbance detection limit were calculated as 0.056 mu M and 0.11 mu M, respectively. Both of these detection limits are below the tolerable limit recommended by WHO for CN- in the drinking water (1.9 mu M). MH-2 was also applied to living cells for bio-imaging and the results showed that the sensor penetrates the cells and can detect cyanide ions in living cells.en_US
dc.identifier.doi10.1016/j.ab.2022.114798
dc.identifier.issn0003-2697
dc.identifier.issn1096-0309
dc.identifier.pmid35779572en_US
dc.identifier.scopus2-s2.0-85133430138en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.ab.2022.114798
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11532
dc.identifier.volume654en_US
dc.identifier.wosWOS:000841161600003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofAnalytical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorimetric Sensoren_US
dc.subjectFluorescent Sensoren_US
dc.subjectCyanide Sensingen_US
dc.subjectBioimagingen_US
dc.titleA rapid responsive coumarin-naphthalene derivative for the detection of cyanide ions in cell cultureen_US
dc.typeArticleen_US

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