A case of pathologic complete response after neoadjuvant triplet chemotherapy for locally advanced colon cancer with mismatch repair enzyme proficiency

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dc.contributor.authorKocak, Mehmet Zahid
dc.contributor.authorCakir, Murat
dc.contributor.authorKerimoglu, Ulku
dc.contributor.authorAraz, Murat
dc.contributor.authorEryilmaz, Melek Karakurt
dc.contributor.authorYumuk, Perran Fulden
dc.contributor.authorArtac, Mehmet
dc.date.accessioned2024-02-23T14:41:50Z
dc.date.available2024-02-23T14:41:50Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPatients with potentially resectable colon cancer and expected to have negative margins should undergo resection rather than neoadjuvant chemotherapy. Recent studies have suggested that neoadjuvant immunotherapy may be an option for tumors with mismatch repair enzyme deficiency (dMMR), but standard treatment for locally advanced colon cancer with mismatch repair enzyme proficiency (pMMR) is still unclear. A 37-year-old male patient was diagnosed with clinical stage IIIC (T4b N1a M0) transverse colon cancer. Mismatch repair proteins were proficient. After 3 cycles of oxaliplatin (85 mg/m(2), day 1), irinotecan (150 mg/m2, IV, day 1), leucovorin (200 mg/m(2), IV, day 1), and 5-fluorouracil (3000 mg/m(2), 46 hours of continuous infusion initiating from day 1), there was a remarkable reduction in the tumoral mass on the abdominal computed tomography. A right hemicolectomy was performed. A pathologic complete response was obtained. Although there is no consensus on which patients are suitable for neoadjuvant therapy in pMMR locally advanced colon cancer, triplet chemotherapy may be a reasonable option in selected patients.en_US
dc.identifier.doi10.5603/OCP.2023.0004
dc.identifier.endpage117en_US
dc.identifier.issn2450-1654
dc.identifier.issn2450-6478
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85164701981en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://doi.org/10.5603/OCP.2023.0004
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17033
dc.identifier.volume19en_US
dc.identifier.wosWOS:000988458800001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofOncology In Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComplete Responseen_US
dc.subjectColon Canceren_US
dc.subjectNeoadjuvanten_US
dc.subjectTriplet Chemotherapyen_US
dc.titleA case of pathologic complete response after neoadjuvant triplet chemotherapy for locally advanced colon cancer with mismatch repair enzyme proficiencyen_US
dc.typeArticleen_US

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