Radioprotective effects of melatonin against varying dose rates on radiotherapy-induced salivary gland damage scintigraphy findings
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of present study was to evaluate the acute radioprotective effect of melatonin against radiotherapy induced rat salivary gland damage by applying salivary gland scintigraphy imaging technique in varying dose rates. Forty-eight Sprague Dawley rats were randomly distributed into six group: the control group, only melatonin (MEL) group, flattening filter (FF-RT) and flattening filter free (FFF-RT) only radiotherapy groups and radiotherapy plus melatonin groups, (FF-RT)+Mel and (FFF-RT)+Mel. The head and neck region of experimental rat was irradiated with in a single fraction of a 16 Gy in FF and FFF modes. Melatonin was administered at a single dose of 10 mg/kg through intraperitoneal injection, 15 min before radiation exposure. The assessment of salivary gland function was performed using gamma scintigraphy prodecure before and after radiotherapy. Statistically significant difference in target-to-background (T/B) ratio, between the only melatonin and control groups were not observed (p = 0.981). However, when acute effects of irradiation are considered after radiotherapy, salivary gland T/B ratios was a significant difference (p < 0.001). In the only radiotherapy groups applied considering in the FF and FFF options no statistically significant difference was observed in the salivary gland T/B ratio FF-RT group compared to the FFF-RT group (p = 0.999). The T/B ratio between the radiotherapy plus melatonin groups for FF-RT and FFF-RT beam was significantly higher in the compared to the only radiotherapy (p < 0.05). In conclusion, our findings suggest that melatonin is a radioprotective agent for treatment of low and high dose rate against acute salivary gland damage during radiotherapy of head and neck cancer.
Açıklama
Anahtar Kelimeler
Flattening Filter Free, Melatonin, Radiotherapy, Salivary Gland, Scintigraphy
Kaynak
Radiation Physics And Chemistry
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
193
