Radioprotective effects of melatonin against varying dose rates on radiotherapy-induced salivary gland damage scintigraphy findings

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dc.contributor.authorAras, Serhat
dc.contributor.authorCan, Uenal
dc.contributor.authorDemir, Hikmettin
dc.contributor.authorSuemer, Engin
dc.contributor.authorOrak, Rahime
dc.contributor.authorTanzer, Ihsan Oguz
dc.contributor.authorBaydili, Kursad Nuri
dc.date.accessioned2024-02-23T14:13:40Z
dc.date.available2024-02-23T14:13:40Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe aim of present study was to evaluate the acute radioprotective effect of melatonin against radiotherapy induced rat salivary gland damage by applying salivary gland scintigraphy imaging technique in varying dose rates. Forty-eight Sprague Dawley rats were randomly distributed into six group: the control group, only melatonin (MEL) group, flattening filter (FF-RT) and flattening filter free (FFF-RT) only radiotherapy groups and radiotherapy plus melatonin groups, (FF-RT)+Mel and (FFF-RT)+Mel. The head and neck region of experimental rat was irradiated with in a single fraction of a 16 Gy in FF and FFF modes. Melatonin was administered at a single dose of 10 mg/kg through intraperitoneal injection, 15 min before radiation exposure. The assessment of salivary gland function was performed using gamma scintigraphy prodecure before and after radiotherapy. Statistically significant difference in target-to-background (T/B) ratio, between the only melatonin and control groups were not observed (p = 0.981). However, when acute effects of irradiation are considered after radiotherapy, salivary gland T/B ratios was a significant difference (p < 0.001). In the only radiotherapy groups applied considering in the FF and FFF options no statistically significant difference was observed in the salivary gland T/B ratio FF-RT group compared to the FFF-RT group (p = 0.999). The T/B ratio between the radiotherapy plus melatonin groups for FF-RT and FFF-RT beam was significantly higher in the compared to the only radiotherapy (p < 0.05). In conclusion, our findings suggest that melatonin is a radioprotective agent for treatment of low and high dose rate against acute salivary gland damage during radiotherapy of head and neck cancer.en_US
dc.description.sponsorshipScientific Research Projects Grants Unit, University of Health Sciences [2019/055]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Grants Unit, University of Health Sciences, [Grant Number: 2019/055].en_US
dc.identifier.doi10.1016/j.radphyschem.2021.109953
dc.identifier.issn0969-806X
dc.identifier.issn1879-0895
dc.identifier.scopus2-s2.0-85122321386en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.radphyschem.2021.109953
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12522
dc.identifier.volume193en_US
dc.identifier.wosWOS:000790008700005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofRadiation Physics And Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlattening Filter Freeen_US
dc.subjectMelatoninen_US
dc.subjectRadiotherapyen_US
dc.subjectSalivary Glanden_US
dc.subjectScintigraphyen_US
dc.titleRadioprotective effects of melatonin against varying dose rates on radiotherapy-induced salivary gland damage scintigraphy findingsen_US
dc.typeArticleen_US

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