A Special Chromosome Imbalance Jumping translocation of 1q in Burkitt Lymphoma
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gazi Univ, Fac Med
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Chromosome 1q gain that confers clonal expansion advantage to tumor cells has been reported in many solid tissue and hematological cancers, in many different forms; sometimes as a derivative chromosome, as isochromosome, or less frequently, due to an imbalance created by a jumping translocation. Although it is known that chromosome 1q gain provide the advantage of clonal expansion to the tumor cells and is relatively common in Burkitt lymphoma/leukemia, its detection in the form of jumping translocation is extraordinarily rare and results of JT containing 1q are controversial. Bone marrow cytogenetic examination performed on a case diagnosed with stage 4 Burkitt lymphoma/leukemia resulted in 46,XY,dup(1)(q21q42),t(8;14)(q24;q32)[5]/46,XY,der(6)t(1;6)(q21;q27),t(8;14)(q 24;q32)[4]/46,XY,t(8;14)(q24;q32), der(11)t(1;11)(q21;q23 )[2]/46,XY[3]. We present the clinical features of the case that was found to have 1q gain in the jumping translocation form to contribute to the literature.
Açıklama
Anahtar Kelimeler
Burkitt's Leukemia, Burkitt's Lymphoma, Bone Marrow, Cytogenetic Abnormalities, Translocation, Chromosomal
Kaynak
Gazi Medical Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
33
Sayı
3
