The reno-protective effects of atorvastatin in crush syndrome and rhabdomyolysis:is there a dilemma?

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dc.authorid0000-0002-3308-5843en_US
dc.contributor.authorAcar, Demet
dc.contributor.authorGülpembe, Mustafa
dc.contributor.authorYıldız, Can Gökay
dc.contributor.authorÖzdamar, Emine Nur
dc.contributor.authorAçıkgöz, Kerem
dc.contributor.authorÇağlar, Ahmet
dc.contributor.authorCander, Başar
dc.date.accessioned2020-01-18T21:02:52Z
dc.date.available2020-01-18T21:02:52Z
dc.date.issued2017
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Anabilim Dalıen_US
dc.description.abstractBackground/aim: We aim to determine the effects of low-dose atorvastatin treatment together with crush fluid resuscitation on renal functions and muscle enzyme levels in a rat model of crush syndrome. Materials and methods: The study involved female Wistar Albino rats weighing 250300 g that were housed with free access to food and water. The crush model was obtained by compression. Rats were randomly divided into four groups: control (C) group, atorvastatin crush fluid (ACF) group, crush fluid (CF) group, and hypertonic saline (%3) mannitol sodium bicarbonate (SM) group. Blood was obtained at 24, 48, and 72 h, and serum creatinine kinase, myoglobin, urea, creatinine, and lactate dehydrogenase levels were studied. Results: All parameters were statistically significantly higher in the control group than in the treatment groups at all hours. However, there was no statistically significant difference among treatment groups regarding any of the parameters. Conclusion: This is the first study determining the role of atorvastatin in the treatment of renal ischemia/reperfusion injury in a crush syndrome and rhabdomyolysis model setting. Larger studies with different atorvastatin doses are required to define the role of this drug in the treatment of renal ischemia/reperfusion injury during crush syndrome.en_US
dc.identifier.citationAcar, D., Gülpembe, M., Yıldız, C. G., Özdamar, E. N., Açıkgöz, K., Çağlar, A., Cander, B. (2017). The reno-protective effects of atorvastatin in crush syndrome and rhabdomyolysis:is there a dilemma?. Turkish Journal of Medical Sciences, 47, 6, 1920-1924.en_US
dc.identifier.endpage1924en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1920en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TWpVME9UUTNOdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1329
dc.identifier.volume47en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectCrush Syndromeen_US
dc.subjectAatorvastatinen_US
dc.subjectRhabdomyolysis
dc.titleThe reno-protective effects of atorvastatin in crush syndrome and rhabdomyolysis:is there a dilemma?en_US
dc.typeArticleen_US

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