Single and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult mice
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Volatile anesthetics are known to disturb the spatial memory in aged rodents, but there is insufficient information on their effects on young adult rodents. The aim of this study was to compare the effects of single and repeated exposure to desflurane and sevoflurane on spatial learning and memory functions in young adult mice. Balb/c mice (2months old) were randomly divided into six equal groups (n=8). The groups with single inhalation were exposed to 3.3% sevoflurane or 7.8% desflurane or vehicle gas for 4h, respectively. The groups with repeated inhalation were exposed to 3.3% sevoflurane or 7.8% desflurane or vehicle gas for 2h a day during 5 consecutive days. Spatial learning and memory were tested in the Morris water maze 24h after exposure. In the learning phase, the parameters associated with finding the hidden platform and swimming speed, and in the memory phase, time spent in the target quadrant and the adjacent quadrants, were assessed and compared between the groups. In the 4-day learning process, there was no significant difference between the groups in terms of mean latency to platform, mean distance traveled and average speed (P>0.05). During the memory-test phase, all mice exhibited spatial memory, but there was no significant difference between the groups in terms of time spent in the target quadrant (P>0.05). Sevoflurane and desflurane anesthesia did not impair acquisition learning and retention memory in young adult mice.
Açıklama
Anahtar Kelimeler
Desflurane, Memory, Postoperative Cognitive Dysfunction, Sevoflurane, Volatile Anaesthetics, Water Maze
Kaynak
Fundamental & Clinical Pharmacology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
27
Sayı
6
