Single and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult mice

Basit Öğe Kaydı
dc.contributor.authorKilicaslan, Alper
dc.contributor.authorBelviranli, Muaz
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorAtalik, Esra Nurullahoglu
dc.date.accessioned2024-02-23T14:24:10Z
dc.date.available2024-02-23T14:24:10Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractVolatile anesthetics are known to disturb the spatial memory in aged rodents, but there is insufficient information on their effects on young adult rodents. The aim of this study was to compare the effects of single and repeated exposure to desflurane and sevoflurane on spatial learning and memory functions in young adult mice. Balb/c mice (2months old) were randomly divided into six equal groups (n=8). The groups with single inhalation were exposed to 3.3% sevoflurane or 7.8% desflurane or vehicle gas for 4h, respectively. The groups with repeated inhalation were exposed to 3.3% sevoflurane or 7.8% desflurane or vehicle gas for 2h a day during 5 consecutive days. Spatial learning and memory were tested in the Morris water maze 24h after exposure. In the learning phase, the parameters associated with finding the hidden platform and swimming speed, and in the memory phase, time spent in the target quadrant and the adjacent quadrants, were assessed and compared between the groups. In the 4-day learning process, there was no significant difference between the groups in terms of mean latency to platform, mean distance traveled and average speed (P>0.05). During the memory-test phase, all mice exhibited spatial memory, but there was no significant difference between the groups in terms of time spent in the target quadrant (P>0.05). Sevoflurane and desflurane anesthesia did not impair acquisition learning and retention memory in young adult mice.en_US
dc.description.sponsorshipNecmettin Erbakan University Research Foundationen_US
dc.description.sponsorshipThis study was supported by the Necmettin Erbakan University Research Foundation.en_US
dc.identifier.doi10.1111/fcp.12027
dc.identifier.endpage649en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue6en_US
dc.identifier.pmid23551531en_US
dc.identifier.scopus2-s2.0-84886585970en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage641en_US
dc.identifier.urihttps://doi.org/10.1111/fcp.12027
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13845
dc.identifier.volume27en_US
dc.identifier.wosWOS:000326103400006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDesfluraneen_US
dc.subjectMemoryen_US
dc.subjectPostoperative Cognitive Dysfunctionen_US
dc.subjectSevofluraneen_US
dc.subjectVolatile Anaestheticsen_US
dc.subjectWater Mazeen_US
dc.titleSingle and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult miceen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu