Comparison of the effects of gabapentin and pregabalin on wound healing in rats
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Gabapentinoids are effective adjunct drugs for reducing postoperative pain. However, the effects of gabapentinoids on wound healing have not been evaluated yet. In this study we evaluated their effects onwound healing. Atotal of 17 maleWistar-Albino rats, 250-350 g, were divided into three groups randomly: control group (n = 5, 2ml saline), gabapentin group (n = 6, 20 mg/kg gabapentin) and pregabalin group (n = 6, 20 mg/kg pregabalin). Until day 13 inflammation scores were significantly lower (P < 0.05) and wound healing was significantly better in the control group when compared with gabapentin and pregabalin groups (P < 0.001). Inflammation scores were significantly lower in pregabalin group when compared with gabapentin group until day 13. But wound healing was significantly better in gabapentin group than in pregabalin group between days 13 and 21. In conclusion when gabapentin and pregabalin were compared, although pregabalin decreases inflammation scores, gabapentin has better results in wound healing.
Açıklama
Anahtar Kelimeler
Gabapentin, Pregabalin, Wound Healing
Kaynak
International Wound Journal
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
13
Sayı
5
