Comparison of the effects of gabapentin and pregabalin on wound healing in rats

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dc.contributor.authorSaritas, Tuba Berra
dc.contributor.authorKorkmaz, Musa
dc.contributor.authorSevimli, Alper
dc.contributor.authorSaritas, Zulfikar Kadir
dc.date.accessioned2024-02-23T14:24:17Z
dc.date.available2024-02-23T14:24:17Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractGabapentinoids are effective adjunct drugs for reducing postoperative pain. However, the effects of gabapentinoids on wound healing have not been evaluated yet. In this study we evaluated their effects onwound healing. Atotal of 17 maleWistar-Albino rats, 250-350 g, were divided into three groups randomly: control group (n = 5, 2ml saline), gabapentin group (n = 6, 20 mg/kg gabapentin) and pregabalin group (n = 6, 20 mg/kg pregabalin). Until day 13 inflammation scores were significantly lower (P < 0.05) and wound healing was significantly better in the control group when compared with gabapentin and pregabalin groups (P < 0.001). Inflammation scores were significantly lower in pregabalin group when compared with gabapentin group until day 13. But wound healing was significantly better in gabapentin group than in pregabalin group between days 13 and 21. In conclusion when gabapentin and pregabalin were compared, although pregabalin decreases inflammation scores, gabapentin has better results in wound healing.en_US
dc.identifier.doi10.1111/iwj.12364
dc.identifier.endpage753en_US
dc.identifier.issn1742-4801
dc.identifier.issn1742-481X
dc.identifier.issue5en_US
dc.identifier.pmid25348659en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage748en_US
dc.identifier.urihttps://doi.org/10.1111/iwj.12364
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13892
dc.identifier.volume13en_US
dc.identifier.wosWOS:000387667600076en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Wound Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGabapentinen_US
dc.subjectPregabalinen_US
dc.subjectWound Healingen_US
dc.titleComparison of the effects of gabapentin and pregabalin on wound healing in ratsen_US
dc.typeArticleen_US

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