The Effects of Genetic Characteristics on the Survival in Myelodysplastic Syndrome Myelodisplastik Sendromda Genetik Ozelliklerin Sagkalim Uzerine Etkisi
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bezmialem Vakif Univ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: This study aimed to evaluate the effects of genetic characteristics on the survival in patients with myelodysplastic syndrome (MDS). Methods: This retrospective study reviewed the data on epidemiological features, main laboratory tests, International Prognostic Scoring System (IPSS) and revised-IPSS risk categories, genetic anomalies, genetic risk categories, and survival in patients who are diagnosed with MDS in our center. According to the IPSS risk categories, patients were classified into three groups as follows: low risk, intermediate-1, and intermediate-2 risk and high risk. The groups were compared using the ANOVA and Kruskal-Wallis tests. Results: The study reviewed the data of 99 patients. The mean age was 66 +/- 11.6 years. A genetic anomaly was detected in 30.3%, of which the most common was del20q (26.7%). The median survival was 61 months [95% confidence interval (CI): 50.9-71] in the study population. The 5-year survival rate was calculated as 64%, 41%, and 33% in low risk, intermediate-1, and intermediate-2 risk and high risk groups, respectively. The predicted median survival rate was 96 months (95% CI: 47.7-144.2), 56 months (95% CI: 34.1-77.8), and 18 months (95% CI: 15.1-20.8), respectively, which indicate a significant difference (log-rank chi-square: 6.6; p=0.035). The risk for mortality was 3.3-folds higher in the intermediate-2 and high risk group compared to the low risk group (RR: 3.3; 95% CI: 1.2-8.6; p=0.017). Conclusion: Our study supports that risk groups that are determined by several parameters, including genetic characteristics, provide predictive information about survival in MDS.
Açıklama
Anahtar Kelimeler
Myelodysplastic Syndromes, Prognosis, Genetics, Survival
Kaynak
Bezmialem Science
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
1
