The Effects of Genetic Characteristics on the Survival in Myelodysplastic Syndrome Myelodisplastik Sendromda Genetik Ozelliklerin Sagkalim Uzerine Etkisi

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dc.contributor.authorTekinalp, Atakan
dc.contributor.authorDemircioglu, Sinan
dc.contributor.authorCelik, Ahmet Faruk
dc.contributor.authorCeneli, Ozcan
dc.date.accessioned2024-02-23T14:29:27Z
dc.date.available2024-02-23T14:29:27Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective: This study aimed to evaluate the effects of genetic characteristics on the survival in patients with myelodysplastic syndrome (MDS). Methods: This retrospective study reviewed the data on epidemiological features, main laboratory tests, International Prognostic Scoring System (IPSS) and revised-IPSS risk categories, genetic anomalies, genetic risk categories, and survival in patients who are diagnosed with MDS in our center. According to the IPSS risk categories, patients were classified into three groups as follows: low risk, intermediate-1, and intermediate-2 risk and high risk. The groups were compared using the ANOVA and Kruskal-Wallis tests. Results: The study reviewed the data of 99 patients. The mean age was 66 +/- 11.6 years. A genetic anomaly was detected in 30.3%, of which the most common was del20q (26.7%). The median survival was 61 months [95% confidence interval (CI): 50.9-71] in the study population. The 5-year survival rate was calculated as 64%, 41%, and 33% in low risk, intermediate-1, and intermediate-2 risk and high risk groups, respectively. The predicted median survival rate was 96 months (95% CI: 47.7-144.2), 56 months (95% CI: 34.1-77.8), and 18 months (95% CI: 15.1-20.8), respectively, which indicate a significant difference (log-rank chi-square: 6.6; p=0.035). The risk for mortality was 3.3-folds higher in the intermediate-2 and high risk group compared to the low risk group (RR: 3.3; 95% CI: 1.2-8.6; p=0.017). Conclusion: Our study supports that risk groups that are determined by several parameters, including genetic characteristics, provide predictive information about survival in MDS.en_US
dc.identifier.doi10.14235/bas.galenos.2021.5758
dc.identifier.endpage28en_US
dc.identifier.issn2148-2373
dc.identifier.issue1en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.14235/bas.galenos.2021.5758
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14710
dc.identifier.volume10en_US
dc.identifier.wosWOS:000748399400006en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBezmialem Vakif Univen_US
dc.relation.ispartofBezmialem Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMyelodysplastic Syndromesen_US
dc.subjectPrognosisen_US
dc.subjectGeneticsen_US
dc.subjectSurvivalen_US
dc.titleThe Effects of Genetic Characteristics on the Survival in Myelodysplastic Syndrome Myelodisplastik Sendromda Genetik Ozelliklerin Sagkalim Uzerine Etkisien_US
dc.typeArticleen_US

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