Ischemia modified albumin Changes During OGTT in Pregnant Women with Gestational Diabetes Mellitus
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Canadian Soc Clinical Investigation
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Published results regarding the oxidative status in gestational diabetes mellitus (GDM) are conflicting. As a biomarker for acute ischemia, ischemia modified albumin (IMA) is associated with pregnancy, especially complicated pregnancies. Our aim was to investigate serum IMA, malondialdehyde (MDA) and total antioxidant status (TAS) levels in patients with GDM. Changes in serum IMA levels after glucose loading during oral glucose tolerance test (OGTT) in pregnant women were also analysed. Methods: OGTT were performed on age-matched participants. Pregnant with abnormal glucose challenge test (GCT), normal glucose tolerance (NGT) (Group 1, n=32) and GDM (Group 2, n=28), defined by ADA criteria, were also performed. Serum IMA, MDA and TAS levels were determined by colorimetric methods. Results: Serum MDA levels in group 2 were significantly higher compared with group 1 (p<0.05) There were no significant differences in serum TAS and IMA levels between two groups (p>0.05). Similar serum IMA levels were obtained in both groups, both at baseline and in the following serum samples during OGTT. In GDM group, there were significant correlations between MDA levels with baseline IMA levels (r=0.51, p=0.005) and first hour IMA levels (r=0.39, p=0.039). Conclusions: Increased oxidative stress may play important role in GDM pathogenesis. Glucose loading does not appear to affect IMA formation; however, larger studies are necessary to understand a wider range of biochemical parameters in large population-based studies of patients with GDM.
Açıklama
Anahtar Kelimeler
[Keyword Not Available]
Kaynak
Clinical And Investigative Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
38
Sayı
4
