Ischemia modified albumin Changes During OGTT in Pregnant Women with Gestational Diabetes Mellitus

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dc.contributor.authorUysal, Saliha
dc.contributor.authorToker, Aysun
dc.contributor.authorAkcay, Merve
dc.contributor.authorGokce, Hacer R.
dc.date.accessioned2024-02-23T14:46:00Z
dc.date.available2024-02-23T14:46:00Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractPurpose: Published results regarding the oxidative status in gestational diabetes mellitus (GDM) are conflicting. As a biomarker for acute ischemia, ischemia modified albumin (IMA) is associated with pregnancy, especially complicated pregnancies. Our aim was to investigate serum IMA, malondialdehyde (MDA) and total antioxidant status (TAS) levels in patients with GDM. Changes in serum IMA levels after glucose loading during oral glucose tolerance test (OGTT) in pregnant women were also analysed. Methods: OGTT were performed on age-matched participants. Pregnant with abnormal glucose challenge test (GCT), normal glucose tolerance (NGT) (Group 1, n=32) and GDM (Group 2, n=28), defined by ADA criteria, were also performed. Serum IMA, MDA and TAS levels were determined by colorimetric methods. Results: Serum MDA levels in group 2 were significantly higher compared with group 1 (p<0.05) There were no significant differences in serum TAS and IMA levels between two groups (p>0.05). Similar serum IMA levels were obtained in both groups, both at baseline and in the following serum samples during OGTT. In GDM group, there were significant correlations between MDA levels with baseline IMA levels (r=0.51, p=0.005) and first hour IMA levels (r=0.39, p=0.039). Conclusions: Increased oxidative stress may play important role in GDM pathogenesis. Glucose loading does not appear to affect IMA formation; however, larger studies are necessary to understand a wider range of biochemical parameters in large population-based studies of patients with GDM.en_US
dc.identifier.endpageE228en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84939171632en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE223en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17742
dc.identifier.volume38en_US
dc.identifier.wosWOS:000359119100015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical And Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleIschemia modified albumin Changes During OGTT in Pregnant Women with Gestational Diabetes Mellitusen_US
dc.typeArticleen_US

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