Multipl sklerozlu olgularda lezyon alanı ve lokalizasyonu ile klinik ve paraklinik bulguların ilişkisi
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
MS is a chronic inflammatory and demyelinating disease of the central nervous system. The diseases involves various sites throughout the CNS with a wide rage of clinical manifestations. It affects relatively young people and has a negative influence an social and occupational functioning of the patient as well as family rebtrans. It is progressive and results in loss of cognitive functions. Secondary psychic reactions may result in various psychiatric disorders. Accumulation of physical disabilities negatively influences the daily life of the patients. The concept of quality of life (QOL) is described as self perception of the subject's status accorching to his own cultural values. The QOL has recently gained importance among chronically ill patients. In this study we aimed to investigate the corelation of QOL with lesion localization and lesion area as well as EDSS scores, clinical and paraclinical findings and socio-demographic features. Thirty-one female and 11 male patients with relapsing-remitting MS who admitted to the outpatient clinic of neurology were included in the study. Their ages ranged between 16-52. The patients had a careful neurological examination, visual, auditory and somatosensory evoked potentials and MRI examination. Area of lesions were measured by the MRI software program and expressed as mm2. Disability level of the patients were determined by EDSS whereas WHOQOL-BREF was used to determine the QOL. MMSE and BECK depression scale were applied to the patients by the psychiatrist. BECK depression scale scores were strongly correlation with disease duration, EDSS score and attack frequency(p=0.001) of the patients. BECK depression scale scores were not corelated with marital status (p=0.255), level of education (p=0.417), sex (0.869), number of plaques (p=0.657), visual evoked potential values (p=0.828) and lesion localization (p=0.170). No sagnificant correlation was found between MMSE scores and attack frequency (p=0.422), number of plagues (p=0.095), lesion location (p=0.446) and lesion area. BECK depression scale scores were significantly corelated with all domains of the WHOQOL-BREF. EDSS scores were significantly correlated with general health/ plessure of living subscale of WHOQOL-BREF (p=0.039) while no corelation was 49found between EDSS and other domains of WHOQOL-BREF. Deep white matter lissions of right periventricular area were correlated with social relationships domain of the WHOQOL-BREF (p=0.035) while deep white matter lesions of left periventricular area were correlated with environment domain of the WHOQOL- BREF (p=0.031). Disease duration (p=0.186), cortical lesion (p=0.176), total lesion areas (p=0.067), and visual evoked potential values were not significantly correlated with WHOQOL-BREF. Lack of correlation between number and localization of lesions and other parameters of QOL, also between total lesion areas and QOL might be due to the heterogeneity of the disease, patient selection criteria and methodological differences is evaluating cognitive functions and MRI lesions. Evaluating cognitive functions with detailed and standardized tests, using diseas spesific scales for measurement of QOL and using functional imaging techniques shold be more informative in further studies.
MS is a chronic inflammatory and demyelinating disease of the central nervous system. The diseases involves various sites throughout the CNS with a wide rage of clinical manifestations. It affects relatively young people and has a negative influence an social and occupational functioning of the patient as well as family rebtrans. It is progressive and results in loss of cognitive functions. Secondary psychic reactions may result in various psychiatric disorders. Accumulation of physical disabilities negatively influences the daily life of the patients. The concept of quality of life (QOL) is described as self perception of the subject's status accorching to his own cultural values. The QOL has recently gained importance among chronically ill patients. In this study we aimed to investigate the corelation of QOL with lesion localization and lesion area as well as EDSS scores, clinical and paraclinical findings and socio-demographic features. Thirty-one female and 11 male patients with relapsing-remitting MS who admitted to the outpatient clinic of neurology were included in the study. Their ages ranged between 16-52. The patients had a careful neurological examination, visual, auditory and somatosensory evoked potentials and MRI examination. Area of lesions were measured by the MRI software program and expressed as mm2. Disability level of the patients were determined by EDSS whereas WHOQOL-BREF was used to determine the QOL. MMSE and BECK depression scale were applied to the patients by the psychiatrist. BECK depression scale scores were strongly correlation with disease duration, EDSS score and attack frequency(p=0.001) of the patients. BECK depression scale scores were not corelated with marital status (p=0.255), level of education (p=0.417), sex (0.869), number of plaques (p=0.657), visual evoked potential values (p=0.828) and lesion localization (p=0.170). No sagnificant correlation was found between MMSE scores and attack frequency (p=0.422), number of plagues (p=0.095), lesion location (p=0.446) and lesion area. BECK depression scale scores were significantly corelated with all domains of the WHOQOL-BREF. EDSS scores were significantly correlated with general health/ plessure of living subscale of WHOQOL-BREF (p=0.039) while no corelation was 49found between EDSS and other domains of WHOQOL-BREF. Deep white matter lissions of right periventricular area were correlated with social relationships domain of the WHOQOL-BREF (p=0.035) while deep white matter lesions of left periventricular area were correlated with environment domain of the WHOQOL- BREF (p=0.031). Disease duration (p=0.186), cortical lesion (p=0.176), total lesion areas (p=0.067), and visual evoked potential values were not significantly correlated with WHOQOL-BREF. Lack of correlation between number and localization of lesions and other parameters of QOL, also between total lesion areas and QOL might be due to the heterogeneity of the disease, patient selection criteria and methodological differences is evaluating cognitive functions and MRI lesions. Evaluating cognitive functions with detailed and standardized tests, using diseas spesific scales for measurement of QOL and using functional imaging techniques shold be more informative in further studies.
MS is a chronic inflammatory and demyelinating disease of the central nervous system. The diseases involves various sites throughout the CNS with a wide rage of clinical manifestations. It affects relatively young people and has a negative influence an social and occupational functioning of the patient as well as family rebtrans. It is progressive and results in loss of cognitive functions. Secondary psychic reactions may result in various psychiatric disorders. Accumulation of physical disabilities negatively influences the daily life of the patients. The concept of quality of life (QOL) is described as self perception of the subject's status accorching to his own cultural values. The QOL has recently gained importance among chronically ill patients. In this study we aimed to investigate the corelation of QOL with lesion localization and lesion area as well as EDSS scores, clinical and paraclinical findings and socio-demographic features. Thirty-one female and 11 male patients with relapsing-remitting MS who admitted to the outpatient clinic of neurology were included in the study. Their ages ranged between 16-52. The patients had a careful neurological examination, visual, auditory and somatosensory evoked potentials and MRI examination. Area of lesions were measured by the MRI software program and expressed as mm2. Disability level of the patients were determined by EDSS whereas WHOQOL-BREF was used to determine the QOL. MMSE and BECK depression scale were applied to the patients by the psychiatrist. BECK depression scale scores were strongly correlation with disease duration, EDSS score and attack frequency(p=0.001) of the patients. BECK depression scale scores were not corelated with marital status (p=0.255), level of education (p=0.417), sex (0.869), number of plaques (p=0.657), visual evoked potential values (p=0.828) and lesion localization (p=0.170). No sagnificant correlation was found between MMSE scores and attack frequency (p=0.422), number of plagues (p=0.095), lesion location (p=0.446) and lesion area. BECK depression scale scores were significantly corelated with all domains of the WHOQOL-BREF. EDSS scores were significantly correlated with general health/ plessure of living subscale of WHOQOL-BREF (p=0.039) while no corelation was 49found between EDSS and other domains of WHOQOL-BREF. Deep white matter lissions of right periventricular area were correlated with social relationships domain of the WHOQOL-BREF (p=0.035) while deep white matter lesions of left periventricular area were correlated with environment domain of the WHOQOL- BREF (p=0.031). Disease duration (p=0.186), cortical lesion (p=0.176), total lesion areas (p=0.067), and visual evoked potential values were not significantly correlated with WHOQOL-BREF. Lack of correlation between number and localization of lesions and other parameters of QOL, also between total lesion areas and QOL might be due to the heterogeneity of the disease, patient selection criteria and methodological differences is evaluating cognitive functions and MRI lesions. Evaluating cognitive functions with detailed and standardized tests, using diseas spesific scales for measurement of QOL and using functional imaging techniques shold be more informative in further studies.
Açıklama
Anahtar Kelimeler
Multipl skleroz, Multiple sclerosis, lezyon alanı, lesion area
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Yaşar, S. (2004). Multipl sklerozlu olgularda lezyon alanı ve lokalizasyonu ile klinik ve paraklinik bulguların ilişkisi. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Dahili Tıp Bilimleri Bölümü Nöroloji Anabilim Dalı, Konya.
