Serum ischemic modified albumin (IMA) concentration and IMA/albumin ratio in patients with hepatitis B-related chronic liver diseases

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dc.authoridMehmet Asıl: 0000-0001-7332-686X
dc.authoridSaliha Uysal: 0000-0002-9815-1039
dc.authoridMehmet Kayrak: 0000-0002-6191-5728
dc.authoridHüseyin Ataseven: 0000-0001-8515-8760
dc.contributor.authorYavuz, Fatma
dc.contributor.authorBıyık, Murat
dc.contributor.authorAsıl, Mehmet
dc.contributor.authorDertli, Ramazan
dc.contributor.authorDemir, Ali
dc.contributor.authorPolat, Hakkı
dc.contributor.authorUysal, Saliha
dc.contributor.authorAtaseven, Hüseyin
dc.date.accessioned2020-01-18T21:14:13Z
dc.date.available2020-01-18T21:14:13Z
dc.date.issued2017
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.descriptionWOS:000404381800035en_US
dc.descriptionPubMed ID:28618749en_US
dc.description.abstractBackground/aim: Albumin is the most important protein synthesized by the liver. Posttranscriptional changes occur in the molecular structure of albumin due to various factors and isoforms arise. Ischemic modified albumin (IMA) is one such isoform. This study was conducted to evaluate serum IMA concentrations in patients with hepatitis B virus (HBV)-related chronic liver diseases. Materials and methods: This study included 74 treatment-naive chronic hepatitis B patients, 25 patients with HBV-related cirrhosis, and 49 healthy controls. Serum IMA concentration was measured spectrophotometrically using the albumin cobalt binding test. Results: The mean IMA concentrations in the chronic hepatitis B group and healthy controls were 0.33 ± 0.11 ABSU and 0.27 ± 0.70 ABSU, respectively, and the difference was statistically significant. Mean IMA/albumin ratios (IMAR) in the chronic hepatitis B and control groups were 0.08 ± 0.04 and 0.06 ± 0.17, respectively, and the difference was also statistically significant (P > 0.001). Higher serum IMA concentrations and IMAR were detected in patients with advanced fibrosis. Conclusion: Serum IMA concentration and IMAR are increased in patients with HBV-related chronic liver diseases and IMA and IMAR are associated with the degree of liver fibrosis. IMA and IMAR may have potential use as noninvasive markers of fibrosis in chronic hepatitis B patients.en_US
dc.identifier.citationYavuz, F., Bıyık, M., Asıl, M., Dertli, R., Demir, A., Polat, H., Uysal, S., Ataseven, H. ( 2017). Serum ischemic modified albumin (IMA) concentration and IMA/albumin ratio in patients with hepatitis B-related chronic liver diseases. Turkish Journal of Medical Sciences, 47, 947-953.en_US
dc.identifier.doi10.3906/sag-1611-66en_US
dc.identifier.endpage953en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue3en_US
dc.identifier.pmid28618749en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage947en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpVME1EYzNOdz09/serum-ischemic-modified-albumin-ima-concentration-and-ima-albumin-ratio-in-patients-with-hepatitis-b-related-chronic-liver-diseases
dc.identifier.urihttps://hdl.handle.net/20.500.12452/3110
dc.identifier.volume47en_US
dc.identifier.wosWOS:000404381800035en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectChronic hepatitis B infection
dc.subjectFibrosis
dc.subjectIschemia-modified albumin
dc.subjectIMAR
dc.titleSerum ischemic modified albumin (IMA) concentration and IMA/albumin ratio in patients with hepatitis B-related chronic liver diseasesen_US
dc.typeArticleen_US

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