Impact of preeclampsia on ventricular repolarization indices

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dc.contributor.authorDuran, Mustafa
dc.contributor.authorZiyrek, Murat
dc.contributor.authorSertdemir, Ahmet Lutfi
dc.contributor.authorGunenc, Oguzhan
dc.contributor.authorBardak, Omer
dc.date.accessioned2024-02-23T14:12:47Z
dc.date.available2024-02-23T14:12:47Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: Because of cardiac hypertrophy and electrophysiological alterations associated with preeclampsia, worsening of preexisting arrhythmias or occurrence of de novo arrhythmias are common in patients with preeclampsia. Tp-e/QT and Tpe/QTc ratios are accepted as reliable indexes for predicting ventricular arrhythmias. In this study, we examined the impact of preeclampsia on ventricular repolarization indices in patients with preeclampsia by using the QT, QTc and Tp-e interval, Tp-e/QTratio, and Tp-e/QTc ratio. Methods: We analyzed electrocardiographic recordings of sixty pregnant women with preeclampsia and thirty age-matched healthy pregnant women. Women presenting with preeclampsia were divided into 2 groups and classified as early (gestational age < 34 weeks at clinical onset) or late (>= 34 weeks) onset preeclampsia. Ventricular repolarization indices were evaluated. Results: The QT and Tp-e intervals were found to be longer in patients with earlyonset preeclampsia compared to patients with late-onset preeclampsia and helthy pregnants (377.6 +/- 23 ms vs 374.3 +/- 15 ms, 362 +/- 15 ms & 82.6 +/- 9.4 ms vs 74.0 +/- 10.6 ms, 68.6 +/- 10 ms). In adition, Tp-e/QT and Tp-e/QTc ratio were significantly higher in this patient population compared to others (0.21 +/- 0.02 vs 0.19 +/- 0.02, 0.18 +/- 0.02 & 0.19 +/- 0.02 vs 0.16 +/- 0.02, 0.15 +/- 0,02, p < 0.05 respectively). Conclusion: Our data showed that preeclampsia has unfavorable effects on electrocardiographic indices of ventricular repolarization compared to healthy pregnant women. This effect is more prominent in patients with early-onset preeclampsia.en_US
dc.identifier.doi10.1016/j.jelectrocard.2021.08.020
dc.identifier.endpage5en_US
dc.identifier.issn0022-0736
dc.identifier.issn1532-8430
dc.identifier.pmid34464917en_US
dc.identifier.scopus2-s2.0-85113771335en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jelectrocard.2021.08.020
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12179
dc.identifier.volume69en_US
dc.identifier.wosWOS:000768195700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstone Inc Medical Publishersen_US
dc.relation.ispartofJournal Of Electrocardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVentricular Repolarization Indicesen_US
dc.subjectPreeclampsiaen_US
dc.titleImpact of preeclampsia on ventricular repolarization indicesen_US
dc.typeArticleen_US

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