Inspection of Endothelial Nitric Oxide Synthase Gene Polymorphism in Patients With Henoch Schönlein Purpura

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dc.authoridMakbule Nihan Somuncu: 0000-0001-6041-457Xen_US
dc.authoridMahmut Selman Yıldırım: 0000-0002-3986-5517en_US
dc.contributor.authorSomuncu, Makbule Nihan
dc.contributor.authorYıldırım, Mahmut Selman
dc.contributor.authorZamani, Ayşegül
dc.contributor.authorPeru, Harun
dc.date.accessioned2020-01-18T21:02:59Z
dc.date.available2020-01-18T21:02:59Z
dc.date.issued2014
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri, Tıbbi Genetik Anabilim Dalıen_US
dc.description.abstractObjectives: This study aims to investigate the effect of Glu298Asp polymorphism, which is observed at endothelial nitric oxide synthase isoform particularly, having a significant impact on endothelial functions of nitric oxide synthase gene and on vascular system in patients with Henoch Schönlein purpura (HSP). Patients and methods: Ninety-five patients who were diagnosed with HSP and 93 healthy controls without any previous vascular disease, hypertension and other cardiovascular diseases were included in this study. The patient group was compared with the controls for Glu298Asp genotype and allele frequencies. The patients were classified according to the clinical complications and were compared with controls and also each other for allele and genotype frequencies. Real-time polymerase chain reaction and LightCycler 2.0 system were used. Results: There was no statistically significant difference in the genotype frequencies between the HSP patients and healthy controls. No significant differences in Glu298Asp gene polymorphism among the patient groups were observed. However, polymorphism had an significant effect on patients with all involvements statistically (P TT0.001, PGG0.000). Conclusion: We conclude that Glu298Asp polymorphism has no effect on the development of HSP vasculitis; however, it may have an impact on the clinical progress of the existing disease.en_US
dc.identifier.citationSomuncu, M. N., Yıldırım, M. S., Zamani, A., Peru, H. (2014). Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. Archives of Rheumatology, 29, 2, 73-80.en_US
dc.identifier.endpage80en_US
dc.identifier.issn2148-5046en_US
dc.identifier.issn2618-6500en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/168325/
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1396
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofArchives of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndothelial nitric oxide synthase geneen_US
dc.subjectGlu298asp polymorphismen_US
dc.subjectHenoch schönlein purpuraen_US
dc.subjectReal time polymerase chain reactionen_US
dc.titleInspection of Endothelial Nitric Oxide Synthase Gene Polymorphism in Patients With Henoch Schönlein Purpuraen_US
dc.typeArticleen_US

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