Role of the nitric oxide on rosuvastatin-induced relaxation of the calf cardiac vein during cooling
Küçük Resim Yok
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Comenius Univ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors including rosuvastatin do not only lower plasma cholesterol but also have non-cholesterol lowering effects on the vessel wall, which decrease cardiovascular complications. The aim of the present study was to evaluate the effect of cooling (to 28 degrees C) on the vasodilatation induced by rosuvastatin (10(-9)-3x10(-4)M) on serotonin-pre-contracted calf cardiac vein and the role of nitric oxide in these effects. Material and methods: Ring preparations of veins obtained from calf hearts were suspended in organ baths containing 25 ml of Krebs-Henseleit solution, maintained at 37 degrees C and continuously gassed with 95% O-2-5% CO2. After a resting period, preparations were contracted with serotonin (10(-6) M) at 37 degrees C. Results: Rosuvastatin produced concentration-dependent relaxation of calf cardiac vein precontracted with serotonin (10(-6) M). During cooling, the pIC(50) value, but not the maximal response, to rosuvastatin was significantly higher than at 37 degrees C. Cooling to 28 degrees C in the presence of N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) decreased the pIC(50) values to rosuvastatin. Conclusion: The results of the present study suggested that nitric oxide played an essential role in the cooling-induced changes of rosuvastatin in calf cardiac vein (Fig. 1, Ref. 23). Text in PDF www.elis.sk.
Açıklama
Anahtar Kelimeler
Cardiac Vein, Cooling, Nitric Oxide, Rosuvastatin
Kaynak
Bratislava Medical Journal-Bratislavske Lekarske Listy
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
115
Sayı
12
